СПЕКТРОСКОПІЯ ЯДЕРНОГО МАГНІТНОГО РЕЗОНАНСУ В АНАЛІЗІ ОБ'ЄКТІВ ДОВКІЛЛЯ

Additional file 3. Multiplication rate

MOESM1 of Cellulose filtration of blood from malaria patients for improving ex vivo growth of Plasmodium falciparum parasites

Additional file 1. Patient characteristics from the children’s ward at Korogwe District Hospital

Characteristics of the 583 newborns included in the FW charts and their mothers.

a<p>) Ethnic groups with less than 2% of the women represented.</p>b<p>) Median.</p>c<p>) BW<2500 g.</p><p>Code: GA = gestational age, G = gram, Kg = kilogram, N = number, SD = standard deviation.</p

Comparison of the different fetal weight charts.

<p>Our Tanzanian chart (—), the Hadlock chart <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044773#pone.0044773-Hadlock1" target="_blank">[21]</a> (-----), the Congolese chart <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044773#pone.0044773-Landis1" target="_blank">[10]</a> (^…), the chart developed using the method suggested by Mikolajzcyk <i>et al </i><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044773#pone.0044773-Mikolajczyk1" target="_blank">[20]</a> modifying the Hadlock chart using local birth weights(–^..–). One vertical line crosses at a GA of 35 weeks and 1 day indicating when the Tanzanian chart's 10^th percentile deviates from the Congolese chart's and the Hadlock chart's 10^th percentiles. One vertical line crosses at a GA of 37 weeks and 1 day indicating when the Tanzanian cohorts' 10^th percentile deviates from the modified Hadlock chart's 10^th percentile.</p

Weight percentiles for the weight chart.

<p>Code: GA = Gestational age in weeks.</p

Fetal weight chart for the Tanzanian cohort.

<p>Both male and female fetuses/newborns are included. The 10^th (black —) 50^th (grey —) and 90^th (black —) percentiles are shown. The weight measurements for the individual fetuses/newborns are superimposed on the chart (^.).</p

The effect of malaria during pregnancy on fetal growth, given as relative fetal growth (g/week*kg), among primi- and secundigravidae.

<p>The effect of malaria during pregnancy on fetal growth, given as relative fetal growth (g/week*kg), among primi- and secundigravidae.</p

Comparison of inflammatory factors in peripheral plasma from <i>P. falciparum</i> infected and uninfected women stratified by gravidity status.

<p>Plasma levels of (A) MCP-1 (B) RANTES, (C) IP-10 and (D) IL-10 according to gravidity of the women. Infected primigravidae (n = 12), uninfected primigravidae (n = 22), infected secundigravidae (n = 17), uninfected secundigravidae (n = 33), infected multigravidae (n = 13) and uninfected multigravidae (n = 25). The boxes represent the values between 25% and 75% quartile and the line indicates the median. The whiskers indicate the 10% and 90% percentiles. <i>P</i>-values were determined by non-parametric Mann-Whitney U test.</p

Proportion of primi and secundigravidae with a fetal weight gain belonging to the lowest 25%, stratified by malaria positivity.

<p>Proportion of primi and secundigravidae with a fetal weight gain belonging to the lowest 25%, stratified by malaria positivity.</p

Different growth patterns after a malaria infection.

<p>The four individual growth patterns are superimposed on a weight chart developed from healthy pregnancies in the cohort <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0053794#pone.0053794-Schmiegelow2" target="_blank">[31]</a>. Normal growth observed after an infection at gestational age (GA) 20+1 (panel A). Immediate effect observed after an infection at GA 20+1 with an initial decline in growth observed in the growth interval antenatal visit (ANV)2– ANV3 followed by persistently normal growth until delivery (panel B). Late effect observed after an infection at a GA 17+0 with normal growth until ANV4 and thereafter a decline in growth until delivery (panel C). Persistent effect observed after an infection at GA 19+6 with decline in growth throughout pregnancy (panel D). The solid vertical lines indicate the timing of the three ANV. In panel B the ANV2 occurred slightly delayed at a GA of 27+2. The solid black and grey lines represent the 90^th, 50^th, and 10^th percentile.</p