2,327 research outputs found
Wage differentials for temporary services work: evidence from administrative data
We use administrative data from the unemployment insurance system State of Washington to study the magnitude of the wage differential associated with work in the temporary services industry. We find that temp wage rates are 15% to 20% below the levels that might have been expected based on trends during other periods in workers' careers even after controlling for differences between temps and other workers. Comparing temp wages immediately before and after temp work or to the wages on non-temp jobs begun during the same period as workers were in the temp industry yields estimates of the temp work penalty as low as 10%.Wages ; Temporary employees
State-of-the-Art Management of Complications of Myeloma and Its Treatment
Multiple myeloma is an incurable disease, although patient survival has increased with the availability of novel agents. Both multiple myeloma and its therapies often affect the renal, immune, skeletal, hematologic, and nervous systems. The resulting organ dysfunctions often impair the quality of life of affected patients, complicate and limit subsequent therapies, and may result in significant mortality. Research on the treatment of complications of multiple myeloma has been limited; hence, preventative and management strategies for patients with these complications are heterogeneous and often based on anecdotal experience. In this paper, we review the effects of myeloma and the novel therapies on organ systems and suggest management strategies
Transplantation of novel human GDF5-expressing CHO cells is neuroprotective in models of Parkinson's disease
Growth/differentiation factor 5 (GDF5) is a neurotrophic factor that promotes the survival of midbrain dopaminergic neurons in vitro and in vivo and as such is potentially useful in the treatment of Parkinson's disease (PD). This study shows that a continuous supply of GDF5, produced by transplanted GDF5-overexpressing CHO cells in vivo, has neuroprotective and neurorestorative effects on midbrain dopaminergic neurons following 6-hydroxydopamine (6-OHDA)-induced lesions of the adult rat nigrostriatal pathway. It also increases the survival and improves the function of transplanted embryonic dopaminergic neurons in the 6-OHDA-lesioned rat model of PD. This study provides the first proof-of-principle that sustained delivery of GDF5 in vivo may be useful in the treatment of PD
The Evolutionary Origin of the Runx/CBFbeta Transcription Factors – Studies of the Most Basal Metazoans
BACKGROUND. Members of the Runx family of transcriptional regulators, which bind DNA as heterodimers with CBFβ, are known to play critical roles in embryonic development in many triploblastic animals such as mammals and insects. They are known to regulate basic developmental processes such as cell fate determination and cellular potency in multiple stem-cell types, including the sensory nerve cell progenitors of ganglia in mammals. RESULTS. In this study, we detect and characterize the hitherto unexplored Runx/CBFβ genes of cnidarians and sponges, two basal animal lineages that are well known for their extensive regenerative capacity. Comparative structural modeling indicates that the Runx-CBFβ-DNA complex from most cnidarians and sponges is highly similar to that found in humans, with changes in the residues involved in Runx-CBFβ dimerization in either of the proteins mirrored by compensatory changes in the binding partner. In situ hybridization studies reveal that Nematostella Runx and CBFβ are expressed predominantly in small isolated foci at the base of the ectoderm of the tentacles in adult animals, possibly representing neurons or their progenitors. CONCLUSION. These results reveal that Runx and CBFβ likely functioned together to regulate transcription in the common ancestor of all metazoans, and the structure of the Runx-CBFβ-DNA complex has remained extremely conserved since the human-sponge divergence. The expression data suggest a hypothesis that these genes may have played a role in nerve cell differentiation or maintenance in the common ancestor of cnidarians and bilaterians.National Science Foundation (IBN-0212773, FP-91656101-0); Boston University SPRInG (20-202-8103-9); Israel Science Foundation (825/07
Complex bounds for multimodal maps: bounded combinatorics
We proved the so called complex bounds for multimodal, infinitely
renormalizable analytic maps with bounded combinatorics: deep renormalizations
have polynomial-like extensions with definite modulus. The complex bounds is
the first step to extend the renormalization theory of unimodal maps to
multimodal maps.Comment: 20 pages, 3 figure
Long-term trends in depression among women separated from abusive partners
This study tested a cumulative adversity hypothesis, where differences in postseparation
stressors among battered women were expected to lead to a widening gap in levels of
women’s depression over time. Ninety-four women separated fromtheir abusive partners
were interviewed six times over a 2-year period. Consistent with the hypothesis, inequalities
grew over time.Women who were exposed to the greatest amount of violence and secondary
stressors shortly after shelter exit experienced relatively higher levels of depression
that either did not improve or significantly increased with time. Social support was
the only resource to have the hypothesized decreasing effect on depression.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90508/1/Anderson-Saunders-Yoshihama-Bybee-Sullivan _2003 Long term trends in depression among survivors VAW.pd
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