Disparity in Maternal Health Services Among the Different Geopolitical Zones in Nigeria

Although the use of antenatal and other skilled maternal health delivery services in Nigeria was reported to be on the increase, this research explored whether geopolitical zone of residence and place of domicile are associated with the number of antenatal visits and place of delivery. A quantitative cross-sectional study based on secondary data from the Demographic and Health Survey was used to examine the relationship between women’s geopolitical zone of residence, place of domicile (rural/urban), and the number of antenatal visits (categorized as fewer than four or four or more) and delivery (home or health facility). A total of 33,385 women aged 15–49 years were recruited from 888 clusters spread across all the 36 states and the federal capital territory of Nigeria using a stratified two stage proportionate to size cluster design. A higher proportion of women from the South West and North Central zones had made four or more antenatal care visits compared to the other geopolitical zones. The difference was statistically significant even after controlling for differences in education, income, ethnicity, religion, autonomy, and place of domicile (adjusted odd ratio = 2.062; 95% confidence interval [1.897, 2.241]; p \u3c .05). Healthcare policy makers should consider the potential impact of geopolitical zones and place of domicile to enable the development of an all-inclusive strategy to robustly address maternal health services in Nigeria

Merozoite surface antigen 2 (MSA-2) gene of Plasmodium falciparum strains from India

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Cloning and sequence analysis of a gene encoding an erythrocyte binding protein from Plasmodium cynomolgi

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Immunoglobulin M Antibody Responses to Mycobacterium ulcerans Allow Discrimination between Cases of Active Buruli Ulcer Disease and Matched Family Controls in Areas Where the Disease Is Endemic

Buruli ulcer disease (BUD) is an emerging disease caused by Mycobacterium ulcerans. In the present study we have characterized the serological reactivities of sera from volunteer case patients with laboratory-confirmed BUD and controls living in three different regions of Ghana where the disease is endemic to determine if serology may be useful for disease confirmation. Our results showed highly reactive immunoglobulin G (IgG) responses among patients with laboratory-confirmed disease, healthy control family members of the case patients, and sera from patients with tuberculosis from areas where BUD is not endemic. These responses were represented by reactivities to multiple protein bands found in the M. ulcerans culture filtrate (CF). In contrast, patient IgM antibody responses to the M. ulcerans CF (MUCF) proteins were more distinct than those of healthy family members living in the same village. A total of 84.8% (56 of 66) of the BUD patients exhibited strong IgM antibody responses against MUCF proteins (30, 43 and 70 to 80 kDa), whereas only 4.5% (3 of 66) of the family controls exhibited such responses. The sensitivity of the total IgM response for the patients was 84.8% (95% confidence interval [CI], 74.3 to 91.6%), and the specificity determined with sera from family controls was 95.5% (95% CI, 87.5 to 98.4%). These studies suggest that the IgM responses of patients with BUD will be helpful in the identification and production of the M. ulcerans recombinant antigens required for the development of a sensitive and specific serological assay for the confirmation of active BUD