Minimum Energy Path to Membrane Pore Formation and Rupture

We combine dynamic self-consistent field theory with the string method to calculate the minimum energy path to membrane pore formation and rupture. In the regime where nucleation can occur on experimentally relevant time scales, the structure of the critical nucleus is between a solvophilic stalk and a locally thinned membrane. Classical nucleation theory fails to capture these molecular details and significantly overestimates the free energy barrier. Our results suggest that thermally nucleated rupture may be an important factor for the low rupture strains observed in lipid membranes

Can economic crises be good for your diet?

With fortuitously timed data - collected before, during and after a major macro-financial crisis in Bulgaria - we revisit several hypotheses in the economics and nutritional literature related to the tendency of households to smooth their nutritional status over time. We explore the dietary impact of both falling real incomes in the context of hyperinflation and crisis and changing relative prices and the changing responsiveness of different groups of people to these incomes and prices over six year of fundamental structural reforms of the economy. Our results highlight large and dramatically changing food and nutrient elasticities, which challenge the perception of household ability to smooth their nutrient stream during economic crises and transitions.Crisis, Diet, Fluctuation, Health, Nutrition

Prototyping Wearables: A Code-First Approach to the Design of Embedded Systems

As wearable devices become ubiquitous, there will be an increased demand for platforms that allow engineers and researchers to quickly prototype and evaluate new wearable devices. However, many of these platforms require that the hardware be configured before the code is written, thereby limiting the programmer to the limitations of the hardware. In this paper, we present a platform that allows researchers and engineers to quickly prototype new wearable devices using a code-first approach. This approach allows software developers to create new prototypes by first writing the code that the prototype is required to run. Once the code has been written, the hardware that is required to run the application can be generated by analyzing the code that the software developer has specified. This code-first approach is possible because of the system\u27s architecture which is comprised of both a hardware and software component. The hardware component consists of a main board with four expansion ports, while the software platform is a modular middleware which consists of a collection of stateless libraries that abstract each hardware module. These modular abstractions allow us to synthesize the hardware configuration from the software definition. We evaluated our design using it to prototype three wearable devices: 1) an environmental exposure monitoring smartwatch; 2) an infrared indoor localization system; and 3) a step counter

Can Economic Crises Be Good for Your Diet?

With fortuitously timed data – collected before, during and after a major macro-financial crisis in Bulgaria – we revisit several hypotheses in the economics and nutritional literature related to the tendency of households to smooth their nutritional status over time. We explore the dietary impact of both falling real incomes in the context of hyperinflation and crisis and changing relative prices and the changing responsiveness of different groups of people to these incomes and prices over six year of fundamental structural reforms of the economy. Our results highlight large and dramatically changing food and nutrient elasticities, which challenge the perception of household ability to smooth their nutrient stream during economic crises and transitions.crisis, diet, fluctuation, health, nutrition

Comparison of the Maximum Gas Combustion Pressure of Hydrogen/Oxygen/Nitrogen-between Chemical Equilibrium Calculations and Experimental Data

AbstractA study was completed comparing equilibrium combustion pressures obtained using constant volume and internal energy constraints to maximum combustion pressures from an existing experimental data base for hydrogen / oxygen and nitrogen mixtures (Jo and Crowl, 2006). We found that the experimental and calculated combustion pressures were close near the stoichiometric combustion point. At other compositions, particularly near the flammable limits, the calculated equilibrium pressures were much higher. Since the maximum pressure is of interest in insuring the design of process equipment and vents, the equilibrium calculation approach can be used instead of experimental data

FMRI Clustering and False Positive Rates

Recently, Eklund et al. (2016) analyzed clustering methods in standard FMRI packages: AFNI (which we maintain), FSL, and SPM [1]. They claimed: 1) false positive rates (FPRs) in traditional approaches are greatly inflated, questioning the validity of "countless published fMRI studies"; 2) nonparametric methods produce valid, but slightly conservative, FPRs; 3) a common flawed assumption is that the spatial autocorrelation function (ACF) of FMRI noise is Gaussian-shaped; and 4) a 15-year-old bug in AFNI's 3dClustSim significantly contributed to producing "particularly high" FPRs compared to other software. We repeated simulations from [1] (Beijing-Zang data [2], see [3]), and comment on each point briefly.Comment: 3 pages, 1 figure. A Letter accepted in PNA