9 research outputs found
The Milan System for Reporting Salivary Gland Cytopathology: Analyses and Suggestions from Initial Survey
BACKGROUND: An international panel of experts in the field of salivary gland cytology (SGC), supported by the American Society of Cytopathology (ASC) and the International Academy of Cytology, conducted a survey to seek evidence and practice patterns regarding SGC. Results were used to provide focus for the proposed Milan System for Reporting Salivary Gland Cytopathology. METHODS: The study group, formed during the 2015 European Congress of Cytology held in Milan, Italy, generated a survey that included 49 specific questions related to the taxonomies, practices, and diagnostic entities of salivary cytology. Qualtrics software was used as the study platform. Software and server support were provided by the division of information technology at the University of Wisconsin. The survey was available online from November 2015 until February 2016. Participants were invited through the Web sites of the ASC, the International Academy of Cytology, and the Papanicolaou Society of Cytopathology as well as by the ASC e-mail âListServeâ; responses were evaluated by the Milan System editors. RESULTS: Responses from a total of 515 participants were collected and reviewed. A total of 347 participants provided demographic data information. Responses revealed variations in diagnostic practice and subsequent management. Participants believed that the acceptable rate for nondiagnostic samples should not be higher than 10%. There were varied opinions regarding the approach to neoplastic lesions of uncertain malignant potential, those that may or may have not local invasion and distant spread. CONCLUSIONS: Results of the survey demonstrated strong support for the development of a unified system for reporting SGC. Cancer Cytopathol 2017;125:757-66. © 2017 American Cancer Society
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Atypical Urothelial Cells (AUC)
The goal for the atypical urothelial cells (AUC) category is to capture those cases worrisome for high-grade urothelial carcinoma (HGUC) but that fall short of the suspicious for HGUC (SHGUC) category. Known causes of atypia, such as polyomavirus change, treatment effect, calculi, etc., should be classified as negative for high-grade urothelial carcinoma (NHGUC). We have set forth criteria for AUCs using the cytomorphologic features: increased nuclear to cytoplasmic (N/C) ratio secondary to nuclear enlargement, abnormal nuclear chromasia and chromatin pattern, and irregularity of the chromatinic rim (nuclear membrane). We recommend restraint using the “AUC” category