Ordering of the tissue samples after single factorization of rank 4 of the entire dataset.

<p>Ordering of the tissue samples after single factorization of rank 4 of the entire dataset.</p

cluster 3.

<p>Common probesets between the top one hundred most influential probesets in the cluster and vehicle dose cluster (cluster 3) of the dataset.</p

Gene cluster comparison for indivdual tissues in the single matrix, “,” with the four separate tissue matrices “.”

<p>H1, SM1, L1 and K1 are the gene clusters most characteristic for the heart, skeletal muscle, liver and kidney, respectively, in the single (combined) data set, as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048238#pone-0048238-g002" target="_blank">Figure 2</a>. Clust.1, 2, or 3 denotes the 100 genes most securely placed within the clusters of the diferently ordered genes in the 4-way factorization shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048238#pone-0048238-g005" target="_blank">Figure 5</a>. The order of the clusters is 1–3, from the top of the figire, for each tissue. We refer to these clusters as “,” etc. The overlap of the from the one-way factorization to is referred to as cluster 1.</p

cluster 1.

<p>Common probesets between the top one hundred most influential probesets in the cluster cluster and 20 mg/kg dosage cluster (cluster 1) of the dataset.</p

Enrichment of KEGG pathways in the common genes between the clusters found by the two ways of factorization.

<p>The probesets common to clusters formed by the 4-way simultaneous factorization and the top one hundred most influential probesets in the four tissue specific clusters were analysed for enrichment of KEGG pathways using DAVID functional annotation tool. Fishers' exact test p-values for pathway enrichment in the clusters are shown graphically in this table. The icon indicates a p-value and the a p-value.</p

cluster 1. Common probesets between the top one hundred most influential probesets in the cluster and 20 mg/kg dosage cluster (cluster 1) of the dataset.

<p> cluster 1. Common probesets between the top one hundred most influential probesets in the cluster and 20 mg/kg dosage cluster (cluster 1) of the dataset.</p

Enrichment of canonical pathways in the four tissue specific gene clusters.

<p>The top one hundred most influential probe-sets in the four tissue specific gene clusters obtained in the first factorization were subjected to signalling and metabolic pathways analysis in the IPA software. This graph shows the comparison of canonical pathways enriched in the four tissue specific gene clusters, , , and . The coloured bars show the significance of the enrichment for a particular pathway in the cluster computed by Fisher's exact test.</p

Enrichment of toxicity functions in the four tissue specific gene clusters.

<p>The top one hundred most influential probe-sets in the four tissue specific gene clusters obtained in the first factorization were subjected to IPA-Tox analysis in the IPA software. This graph shows the comparison of toxicity functions enriched in the four tissue specific gene clusters. The coloured bars show the significance of the enrichment for a particular toxicity functions in the cluster computed by Fisher's exact test.</p

cluster 3.

<p>Common probesets between the top one hundred most influential probesets in the cluster and vehicle dose cluster (cluster 3) of the dataset.</p

Enrichment of KEGG pathways in the four tissue specific gene clusters.

<p>The top one hundred most influential probesets in the four tissue specific gene clusters were analysed using DAVID functional annotation tool. This table shows the comparison of KEGG pathways enriched in the four tissue specific gene clusters. The icon indicates a p-value and the a p-value showing the significance of the enrichment.</p