Utilization of deep learning to quantify fluid volume of neovascular age-related macular degeneration patients based on swept-source OCT imaging: The ONTARIO study.

PURPOSE: To evaluate the predictive ability of a deep learning-based algorithm to determine long-term best-corrected distance visual acuity (BCVA) outcomes in neovascular age-related macular degeneration (nARMD) patients using baseline swept-source optical coherence tomography (SS-OCT) and OCT-angiography (OCT-A) data. METHODS: In this phase IV, retrospective, proof of concept, single center study, SS-OCT data from 17 previously treated nARMD eyes was used to assess retinal layer thicknesses, as well as quantify intraretinal fluid (IRF), subretinal fluid (SRF), and serous pigment epithelium detachments (PEDs) using a novel deep learning-based, macular fluid segmentation algorithm. Baseline OCT and OCT-A morphological features and fluid measurements were correlated using the Pearson correlation coefficient (PCC) to changes in BCVA from baseline to week 52. RESULTS: Total retinal fluid (IRF, SRF and PED) volume at baseline had the strongest correlation to improvement in BCVA at month 12 (PCC = 0.652, p = 0.005). Fluid was subsequently sub-categorized into IRF, SRF and PED, with PED volume having the next highest correlation (PCC = 0.648, p = 0.005) to BCVA improvement. Average total retinal thickness in isolation demonstrated poor correlation (PCC = 0.334, p = 0.189). When two features, mean choroidal neovascular membranes (CNVM) size and total fluid volume, were combined and correlated with visual outcomes, the highest correlation increased to PCC = 0.695 (p = 0.002). CONCLUSIONS: In isolation, total fluid volume most closely correlates with change in BCVA values between baseline and week 52. In combination with complimentary information from OCT-A, an improvement in the linear correlation score was observed. Average total retinal thickness provided a lower correlation, and thus provides a lower predictive outcome than alternative metrics assessed. Clinically, a machine-learning approach to analyzing fluid metrics in combination with lesion size may provide an advantage in personalizing therapy and predicting BCVA outcomes at week 52

An Expectation Maximization-Like Algorithm for Multi-Atlas Multi-Label Segmentation

Copyright c ○ 2003 Springer-Verlag. This paper was published in Bildverarbeitung für die Medizi

Fuzzy segmentation of X-ray fluoroscopy images

Segmentation of fluoroscopy images is useful for fluoroscopy-to-CT image registration. However, it is impossible to assign a unique tissue type to each pixel. Rather each pixel corresponds to an entire path of tissue types encountered along a ray from the X-ray source to the detector plate. Furthermore, there is an inherent many-to-one mapping between paths and pixel values. We address these issues by assigning to each pixel not a scalar value but a fuzzy vector of tissue probabilities. We perform this segmentation in a probabilistic way by first learning typical distributions of bone, air, andsoft tissue that correspondto certain fluoroscopy image values andthen assigning each value to a probability distribution over its most likely generating paths. We then evaluate this segmentation on ground truth patient data. Keywords: fuzzy segmentation, fluoroscopy, probabilistic DRR, image registration, CT. 1