7,953 research outputs found
Optimising Matrix Product State Simulations of Shor's Algorithm
We detail techniques to optimise high-level classical simulations of Shor's
quantum factoring algorithm. Chief among these is to examine the entangling
properties of the circuit and to effectively map it across the one-dimensional
structure of a matrix product state. Compared to previous approaches whose
space requirements depend on , the solution to the underlying order-finding
problem of Shor's algorithm, our approach depends on its factors. We performed
a matrix product state simulation of a 60-qubit instance of Shor's algorithm
that would otherwise be infeasible to complete without an optimised
entanglement mapping.Comment: 8 pages, 2 figures, 2 tables. v2 using PDFLaTeX compiler. v3 to
include extra references. v4 for publication in Quantu
Deep learning techniques and mathematical modeling allow 3D analysis of mitotic spindle dynamics
Time-lapse microscopy movies have transformed the study of subcellular dynamics. However, manual analysis of movies can introduce bias and variability, obscuring important insights. While automation can overcome such limitations, spatial and temporal discontinuities in time-lapse movies render methods such as 3D object segmentation and tracking difficult. Here, we present SpinX, a framework for reconstructing gaps between successive image frames by combining deep learning and mathematical object modeling. By incorporating expert feedback through selective annotations, SpinX identifies subcellular structures, despite confounding neighbor-cell information, non-uniform illumination, and variable fluorophore marker intensities. The automation and continuity introduced here allows the precise 3D tracking and analysis of spindle movements with respect to the cell cortex for the first time. We demonstrate the utility of SpinX using distinct spindle markers, cell lines, microscopes, and drug treatments. In summary, SpinX provides an exciting opportunity to study spindle dynamics in a sophisticated way, creating a framework for step changes in studies using time-lapse microscopy
The Insula and Its Epilepsies
Insular seizures are great mimickers of seizures originating elsewhere in the brain. The insula is a highly connected brain structure. Seizures may only become clinically evident after ictal activity propagates out of the insula with semiology that reflects the propagation pattern. Insular seizures with perisylvian spread, for example, manifest first as throat constriction, followed next by perioral and hemisensory symptoms, and then by unilateral motor symptoms. On the other hand, insular seizures may spread instead to the temporal and frontal lobes and present like seizures originating from these regions. Due to the location of the insula deep in the brain, interictal and ictal scalp electroencephalogram (EEG) changes can be variable and misleading. Magnetic reso- nance imaging, magnetic resonance spectroscopy, magnetoencephalography, positron emission tomography, and single-photon computed tomography imaging may assist in establishing a diagnosis of insular epilepsy. Intracranial EEG recordings from within the insula, using stereo-EEG or depth electrode techniques, can prove insular seizure origin. Seizure onset, most commonly seen as low-voltage, fast gamma activity, however, can be highly localized and easily missed if the insula is only sparsely sampled. Moreover, seizure spread to the contralateral insula and other brain regions may occur rapidly. Extensive sampling of the insula with multiple electrode trajectories is necessary to avoid these pitfalls. Understanding the functional organization of the insula is helpful when interpreting the semiology produced by insular seizures. Electrical stimulation mapping around the central sulcus of the insula results in paresthesias, while stimulation of the posterior insula typically produces painful sensations. Visceral sensations are the next most common result of insular stimulation. Treatment of insular epilepsy is evolving, but poses challenges. Surgical resections of the insula are effective but risk significant morbidity if not carefully planned. Neurostimulation is an emerging option for treatment, especially for seizures with onset in the posterior insula. The close association of the insula with marked autonomic changes has led to interest in the role of the insula in sudden unexpected death in epilepsy and warrants additional study with larger patient cohorts
Synthesis and Characterization of β-Cyclodextrin/alginate Nanoparticle as a Novel Drug Delivery System
The aim of this work was to study a novel nanoparticle system formed from alginate and β-cyclodextrin by ionotropic gelation method and to evaluate their potential for the association and delivery of drugs. The nanoparticles were prepared by electrostatic interactions between Ca2+/alginate gel and β-cyclodextrin. Morphology and structure characterization of nanoparticles was investigated by scanning electron micrographs (SEM), transmission electron microscope (TEM), Fourier transform infrared spectra (FTIR). The nanoparticle size was about 50 – 80 nm and their structure quite regular and consistent.
Ketoprofen, chosen as a model drug, was incorporated into the nanocarriers with association efficiency of 50.7 % and loading efficiency of 5.7 %. Ketoprofen released from the nanoparticles was 57 % at pH 7.4 and 69 % at pH 5.0 for 4 h
Relativistic Coulomb Sum Rules for
A Coulomb sum rule is derived for the response of nuclei to
scattering with large three-momentum transfers. Unlike the nonrelativistic
formulation, the relativistic Coulomb sum is restricted to spacelike
four-momenta for the most direct connection with experiments; an immediate
consequence is that excitations involving antinucleons, e.g., pair
production, are approximately eliminated from the sum rule. Relativistic recoil
and Fermi motion of target nucleons are correctly incorporated. The sum rule
decomposes into one- and two-body parts, with correlation information in the
second. The one-body part requires information on the nucleon momentum
distribution function, which is incorporated by a moment expansion method. The
sum rule given through the second moment (RCSR-II) is tested in the Fermi gas
model, and is shown to be sufficiently accurate for applications to data.Comment: 32 pages (LaTeX), 4 postscript figures available from the author
The hyperon mean free paths in the relativistic mean field
The - and -hyperon mean free paths in nuclei are firstly
calculated in the relativistic mean field (RMF) theory. The real parts of the
optical potential are derived from the RMF approach, while the imaginary parts
are obtained from those of nucleons with the relations:
and . With the
assumption, the depth of the imaginary potential for is
3.5 MeV, and for is 7 MeV at
low incident energy. We find that, the hyperon mean free path decreases with
the increase of the hyperon incident energies, from 200 MeV to 800 MeV; and in
the interior of the nuclei, the mean free path is about fm for
, and about fm for , depending on the hyperon
incident energy.Comment: 5 figures, 6 page
Order in extremal trajectories
Given a chaotic dynamical system and a time interval in which some quantity
takes an unusually large average value, what can we say of the trajectory that
yields this deviation? As an example, we study the trajectories of the
archetypical chaotic system, the baker's map. We show that, out of all
irregular trajectories, a large-deviation requirement selects (isolated) orbits
that are periodic or quasiperiodic. We discuss what the relevance of this
calculation may be for dynamical systems and for glasses
Competing magnetic fluctuations in Sr3Ru2O7 probed by Ti doping
We report the effect of nonmagnetic Ti4+ impurities on the electronic and
magnetic properties of Sr3Ru2O7. Small amounts of Ti suppress the
characteristic peak in magnetic susceptibility near 16 K and result in a sharp
upturn in specific heat. The metamagnetic quantum phase transition and related
anomalous features are quickly smeared out by small amounts of Ti. These
results provide strong evidence for the existence of competing magnetic
fluctuations in the ground state of Sr3Ru2O7. Ti doping suppresses the low
temperature antiferromagnetic interactions that arise from Fermi surface
nesting, leaving the system in a state dominated by ferromagnetic fluctuations.Comment: 5 pages, 4 figures, 1 tabl
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