Superfocusing, Biosensing and Modulation in Plasmonics

Plasmonics could bridge the gap between photonics and electronics at the nanoscale, by allowing the realization of surface-plasmon-based circuits and plasmonic chips in the future. To build up such devices, elementary components are required, such as a passive plasmonic lens to focus free-space light to nanometre area and an active plasmonic modulator or switch to control an optical response with an external signal (optical, thermal or electrical). This thesis partially focuses on designing novel passive and active plasmonic devices, with a specific emphasis on the understanding of the physical principles lying behind these nanoscale optical phenomena. Three passive plasmonic devices, designed by conformal transformation optics, are numerically studied, including nanocrescents, kissing and overlapping nanowire dimers. Contrary to conventional metal nanoparticles with just a few resonances, these devices with structural singularities are able to harvest light over a broadband spectrum and focus it into well-defined positions, with potential applications in high efficiency solar cells and nanowire-based photodetectors and nanolasers. Moreover, thermo-optical and electrooptical modulation of plasmon resonances are realized in metallic nanostructures integrated with either a temperature-controlled phase transition material (vanadium dioxide, VO2), or ferroelectric thin films. Taking advantage of the high sensitivity of particle plasmon resonances to the change of its surrounding environment, we develop a plasmon resonance nanospectroscopy technique to study the effects of sizes and defects in the metal-insulator phase transition of VO2 at the single-particle level, and even single-domain level. Finally, we propose and examine the use of two-dimensional metallic nanohole arrays as a refractive index sensing platform for future label-free biosensors with good surface sensitivity and high-throughput detection ability. The designed plasmonic devices have great potential implications for constructing nextgeneration optical computers and chip-scale biosensors. The developed plasmon resonance nanospectroscopy has the potential to probe the interfacial or domain boundary scattering in polycrystalline and epitaxial thin films

The impact of physical environments in satisfaction in shopping centers

Lighting, thermal and acoustic are three main components of indoor physical environments affecting people’s satisfaction, productivity and health. Good physical environments in shopping centers not only improve the environment atmosphere but also increase the customers’ satisfaction. This study aims to find correlations between the physical environments and the satisfaction levels. Firstly, an objective measurement of physical environments had been carried out in four shopping centers. Then, a subjective evaluation was carried out in a real scene laboratory by changing four kinds of illuminance and three types of Correlated Color Temperatures (CCTs), which aims to find the relationship between the lighting environment and people’s lighting, thermal and acoustic satisfaction. Moreover, the interaction of satisfaction levels were also explored. The results of field study showed that lighting and acoustic environments have a wide fluctuate range in four shopping centers. The experiment found that illuminance has a significant effect on lighting satisfaction and is best at 1000 lux (lx). The thermal and acoustic satisfaction were not directly influenced by lighting parameters; however, they had the interactions with lighting satisfaction, which showed that lighting environment would enhance the satisfaction levels of thermal and acoustic environments when it was satisfied

Doping-free complementary WSe2 circuit via van der Waals metal integration.

Two-dimensional (2D) semiconductors have attracted considerable attention for the development of ultra-thin body transistors. However, the polarity control of 2D transistors and the achievement of complementary logic functions remain critical challenges. Here, we report a doping-free strategy to modulate the polarity of WSe2 transistors using same contact metal but different integration methods. By applying low-energy van der Waals integration of Au electrodes, we observed robust and optimized p-type transistor behavior, which is in great contrast to the transistors fabricated on the same WSe2 flake using conventional deposited Au contacts with pronounced n-type characteristics. With the ability to switch majority carrier type and to achieve optimized contact for both electrons and holes, a doping-free logic inverter is demonstrated with higher voltage gain of 340, at the bias voltage of 5.5 V. Furthermore, the simple polarity control strategy is extended for realizing more complex logic functions such as NAND and NOR

Dichlorido(2,9-diprop­oxy-1,10-phenanthroline-κ2 N,N′)cadmium(II)

In the title complex, [CdCl2(C18H20N2O2)], the CdII ion is coordinated by two N atoms from a bis-chelating 2,9-diprop­oxy-1,10-phenanthroline ligand and two Cl atoms in a distorted tetra­hedral environment. The two Cd—Cl bond distances are significantly different from each other and the N—Cd—N bond angle is acute. In the crystal structure, there are π–π stacking inter­actions between symmetry-related phenanthroline ring systems, with a centroid–centroid distance of 3.585 (3) Å

MiR-145 inhibits oral squamous cell carcinoma (OSCC) cell growth by targeting c-Myc and Cdk6

BACKGROUND: MicroRNAs (miRNAs) are a large group of negative gene regulators that potentially play a critical role in tumorigenesis. Increasing evidences indicate that miR-145 acts a tumor suppressor in numerous human cancers. However, its role in oral carcinogenesis remains poorly defined. The aim of this study is to determine expression levels of miR-145 in oral squamous cell carcinomas (OSCCs) and normal mucosa tissues, and explore its biological functions in OSCCs. METHODS: Reverse transcription quantitative real-time PCR (RT-qPCR) assay was used to evaluate expression levels of miR-145. The biological functions of miR-145 were determined by cell proliferation and colony formation, cell cycle and apoptosis, as well as cell invasion assay. RESULTS: MiR-145 was frequently down-regulated in OSCCs compared with normal mucosa tissues. Restoring miR-145 expression in OSCC cells dramatically suppressed cell proliferation and colony formation, and induced G1 phase arrest and cell apoptosis. Importantly, our data showed that miR-145 downregulated the expression of c-Myc and Cdk6, which have previously been identified as two direct targets of miR-145. CONCLUSIONS: Our data suggest that miR-145 exerts its tumor suppressor function by targeting c-Myc and Cdk6, leading to the inhibition of OSCC cell growth. MiR-145 rescue may thus be a rational for diagnostic and therapeutic applications in OSCC

Hemoglobin levels and anemia evaluation during pregnancy in the highlands of Tibet: a hospital-based study.

BACKGROUND: Anemia is regarded as a major risk factor for unfavorable pregnancy outcomes, but there have been no previous studies describing the pattern of hemoglobin concentration during pregnancy in Tibet and the relationship between altitude and Hb concentration in the pregnant women living in Tibet still has not been clearly established. The main objectives of this study were to study the hemoglobin levels and prevalence of anemia among pregnant women living in the highlands of Tibet and to evaluate potential associations of hemoglobin and anemia with women's characteristics. METHODS: The hospital-based study was conducted in 380 pregnant women. Their blood samples were tested and related sociodemographic information was collected. Multiple linear regression model and multiple logistic regression model were used to assess the association of pregnant women's characteristics with hemoglobin level and the occurrence of anemia. Centers for Disease Control (CDC), Dirren et al. and Dallman et al. methods were used to adjust the hemoglobin measurements based on altitude for estimating the prevalence of anemia. RESULTS: The mean hemoglobin concentration was 127.6 g/L (range: 55.0-190.0 g/L). Prevalence rate of anemia in this study was 70.0%, 77.9% and 41.3%, respectively for three altitude-correction methods for hemoglobin (CDC method, Dirren et al. method, and Dallman et al. method). Gestational age, ethnicity, residence and income were significantly associated with the hemoglobin concentration and prevalence of anemia in the study population. Specially, the hemoglobin concentration of pregnant women decreased with increase in gestational age. CONCLUSION: The hemoglobin level was low and prevalence rate of anemia was high among pregnant women in Lhasa, Tibet. Gestational age, ethnicity, residence and income were found to be significantly associated with the hemoglobin level and the occurrence of anemia in the study population