Observation on health quality of life before and after the injection of antiangiogenic drug in vitreous cavity to patients with wet age-related macular degeneration

AbstractObjectiveTo explore the vision related health quality-of-life before and after the injection of antiangiogenic drug in vitreous cavity to patients with wet-AMD.MethodsThe 2000 edition of Visual Functioning Questionnaire-25 issued by National Eye Institute is applied, and the VRQL evaluation is conducted on the initial diagnosed patients with wet-AMD before and after the injection of ranibizumab drugs in vitreous cavity.ResultsAmong the wet-AMD patients, patients with better distance visual acuity before the intravitreal injection get lower VFQ-25 score; while after the vitreous cavity injection, the VFQ-25 questionnaire score is related to the explanation and nursing of doctors and nurses towards patients, the better the nursing, the higher the score.ConclusionBefore vitreous cavity injection, the degree of distance visual acuity is an important factor affecting VRQL of wet-AMD patients, in addition, the explanation and nursing of doctors and nurses toward patients during pre-operation, intra-operation and post-operation of intravitreal injection are also the import factors affecting VROL

Multiaperture planar waveguide spectrometer formed by arrayed Mach-Zehnder interferometers

Concept, theory and simulations of a new type of waveguide device, a multiaperture Fourier-transform planar waveguide spectrometer, are presented. The spectrometer is formed by an array of Mach-Zehnder interferometers generating a wavelength dependent spatial fringe pattern at the array output. The input light spectrum is calculated using a discrete Fourier transformation of the output spatial fringes. The multiaperture input significantly increases the optical throughput (étendue) compared to conventional single input spectrometers. Design rules for the arrayed spectrometer are deduced from performance specifications such as wavelength range and spectral resolution. A design example with spectral resolution 0.025 nm and range 2.5 nm is presented, where the optical throughput is increased by a factor of 200 compared to a single input device