1 research outputs found
Diastereo- and Enantioselective Construction of Dihydrobenzo[<i>e</i>]indole Scaffolds via Catalytic Asymmetric [3 + 2] Cycloannulations
The first catalytic
asymmetric construction of chiral dihydrobenzo[<i>e</i>]indole
scaffolds has been established in a highly diastereo-
and enantioselective mode (30 examples, up to 99% yield, >95:5
dr,
>99% ee), which makes use of chiral phosphoric acid-catalyzed [3
+
2] cycloannulations of azonaphthalene derivatives with 3-vinylindoles.
This reaction also represents the first catalytic asymmetric cycloannulation
of azonaphthalene derivatives with alkenes, which will not only provide
a useful method for constructing enantioenriched dihydrobenzo[<i>e</i>]indole scaffolds but also advance the chemistry of catalytic
asymmetric reactions of azonaphthalene derivatives