Additional file 1: of Lack of efficacy of pomegranate supplementation for glucose management, insulin levels and sensitivity: evidence from a systematic review and meta-analysis

GRADE Evidence Profile. (DOC 38 kb

Forest plot of the risk of nasopharyngeal carcinoma associated with the CCND1 G870A polymorphism.

<p>A, the alleles model (A vs. G); B, the co-dominant model (AA vs. GG); C, the dominant model (AA/AG vs. GG); D, the recessive model (AA vs. AG/GG). Error bars indicate 95% CI. Solid squares represent each study in the meta-analysis. Solid diamonds represent pooled OR.</p

Begger’s funnel plots for publication bias of the meta-analysis on the association between CCND1 G870A polymorphism and NPC risk in co-dominant model (AA vs. GG).

<p>Begger’s funnel plots for publication bias of the meta-analysis on the association between CCND1 G870A polymorphism and NPC risk in co-dominant model (AA vs. GG).</p

Influence analysis for the co-dominant model (AA vs. GG) in the overall meta-analysis.

<p>This figure shows the influence of individual studies on the summary OR. The middle vertical axis indicates the overall OR and the two vertical axes indicate its 95% CI. Every hollow round indicates the pooled OR when the left study is omitted in this meta-analysis. The two ends of the dotted lines represent the 95% CI.</p

The characteristics of the included studies in the meta analysis.

<p>The characteristics of the included studies in the meta analysis.</p

Meta-analysis of cylin D1(CCND1) polymorphism and risk of NPC.

<p>Abbreviations: CI, confident interval; OR, odd ratio; R, random model; F, fixed model.</p><p>Meta-analysis of cylin D1(CCND1) polymorphism and risk of NPC.</p

The influence of rs2488457 on the mRNA expression of PTPN22.

<p>The mRNA expression of PTPN22 in PBMCs from normal controls carrying different genotypes of rs2488457 (CC = 18, CG = 31, GG = 9). Data are represented as the mean ± SD.</p

The influence of rs2488457 on the activation of CD4+ T cells.

<p>(A) The frequency of CD4⁺CD44⁺CD69⁺ T cells from normal controls carrying different genotypes of rs2488457 (CC = 9, CG = 18, GG = 4). (B) The frequency of CD4⁺CD44⁺CD25⁺ T cells from normal controls carrying different genotypes of rs2488457 (CC = 9, CG = 18, GG = 4). Data are represented as the mean.</p

The influence of rs2488457 on the cytokine production.

<p>The production of IL-10(A), IL-8(B), IL-6(C), IFN-γ(D), IL-17(E), TNF-α(F), IL-1β(G) and MCP-1(H) by PBMCs from normal controls carrying different genotypes of rs2488457 (CC = 18, CG = 31, GG = 9). Data are represented as the mean.</p

The influence of rs2488457 on the proliferation of PBMCs.

<p>The proliferation of anti-CD3/CD28 stimulated PBMCs from normal controls carrying different genotypes of rs2488457 (CC = 18, CG = 31, GG = 9). Data are represented as the mean ± SEM.</p