Gastrointestinal stromal tumor (GIST) of the Treitz’s angle– a very rare cause of high bowel obstruction

Gastrointestinal stromal tumors (GIST) are somewhat rare gastrointestinal tumors - approximately 1% to 3% incidence, but they are the most common mesenchymal neoplasms of the gastrointestinal tract. GISTs are usually found in the stomach or small intestine but can occur anywhere within the gastrointestinal tract, even in extremely uncommon locations like duodeno-jejunal flexure. Only 3% – 5% of GISTs are located in the duodenum and tumors occurring in the angle of Treitz are even rarer, most published studies being case reports. These tumors have a size ranging from small lesions to large masses and can cause digestive bleeding or high bowel obstruction. This paper is a case presentation illustrating an emergency situation involving a high bowel obstruction caused by a small tumor with an unusual location in the Treitz’s angle. A large percentage of duodenal GISTs are localized in the third and fourth part of the duodenum and may not be found through standard upper endoscopy; only the barium study of the upper gastrointestinal tract highlights the obstruction point. Preoperative diagnosis is difficult but non-invasive imaging techniques like ultrasonography and computed tomography of the abdomen can be helpful. Recently, targeted therapy with inhibitors of tyrosine kinase receptors (IMATINIB) has been introduced for the management of advanced and metastatic tumors. In our opinion the surgical resection with curative intent is the treatment of choice

Hedbergella yezoana est un nom d'espèce valide : Remarques sur le cas 3620 et la décision (avis n°2362) formulée par la Commission Internationale de Nomenclature Zoologique

International Commission of Zoological Nomenclature decided in September 2015 on case 3620 submitted by A. Ando (United States National Museum, Smithsonian Institution, Washington, D.C.), which regards the status of the species Ticinella primula Luterbacher in Renz et al., 1963, and Hedbergella trocoidea yezoana Takayanagi & Iwamoto, 1962. Decision was to place the former on the Official List of Specific Names in Zoology and the latter on the Official Index of Rejected and Invalid Specific Names in Zoology (ICZN, 2015, p. 227). The scientific fundamentals in the presentation of case 3620 are weak and do not support such a decision by the International Commission. Moreover, they create a significant disturbance of nomenclatural stability in the Linnaean classification of the Cretaceous planktonic foraminifera.La Commission Internationale de Nomenclature Zoologique a statué en Septembre 2015 sur la cas 3620 soumis par A. Ando (Museum National des États-Unis, Smithsonian Institution, Washington, D.C.) concernant le statut des espèces de foraminifères planctoniques Ticinella primula Luterbacher in Renz et al., 1963, et Hedbergella trocoidea yezoana Takayanagi & Iwamoto, 1962. La décision de la Commission fut de placer la première espèce sur la Liste Officielle des Noms Spécifiques en Zoologie et la seconde dans l'Index Officiel des Noms Spécifiques Rejetés et Invalides en Zoologie (ICZN, 2015, p. 227). Les arguments scientifiques fondamentaux fournis dans la présentation du cas 3620 sont faibles et n'étayent pas une telle décision de la Commission Internationale. De plus, ils créent une perturbation significative de la stabilité nomenclaturale dans la classification linnéenne des foraminifères planctoniques crétacés

Cold-formed Steel Sections Experimental Data Base

Thin-walled cold-formed member critical load in the coupling point of overall/local buckling modes is defined, together with critical load erosion factor (ψ). A calibration method for (ψ) using an experimental database called DATACOST is presented

Evaluation of New Morphometric Parameters of Neoangiogenesis in Human Colorectal Cancer Using Confocal Laser Endomicroscopy (CLE) and Targeted Panendothelial Markers

The tumor microcirculation is characterized by an abnormal vascular network with dilated, tortuous and saccular vessels. Therefore, imaging the tumor vasculature and determining its morphometric characteristics represent a critical goal for optimizing the cancer treatment that targets the blood vessels (i.e. antiangiogenesis therapy). The aim of this study was to evaluate new vascular morphometric parameters in colorectal cancer, difficult to achieve through conventional immunohistochemistry, by using the confocal laser endomicroscopy method. Fresh biopsies from tumor and normal tissue were collected during colonoscopy from five patients with T3 colorectal carcinoma without metastasis and were marked with fluorescently labeled anti-CD31 antibodies. A series of optical slices spanning 250 µm inside the tissue were immediately collected for each sample using a confocal laser endomicroscope. All measurements were expressed as the mean ± standard error. The mean diameter of tumor vessels was significantly larger than the normal vessels (9.46±0.4 µm vs. 7.60±0.3 µm, p = 0.0166). The vessel density was also significantly higher in the cancer vs. normal tissue samples (5541.05±262.81 vs. 3755.79±194.96 vessels/mm3, p = 0.0006). These results were confirmed by immunohistochemistry. In addition, the tortuosity index and vessel lengths were not significantly different (1.05±0.016 and 28.30±3.27 µm in normal tissue, vs. 1.07±0.008 and 26.49±3.18 µm in tumor tissue respectively, p = 0.5357 and p = 0.7033). The daughter/mother ratio (ratio of the sum of the squares of daughter vessel radii over the square of the mother vessel radius) was 1.15±0.09 in normal tissue, and 1.21±0.08 in tumor tissue (p = 0.6531). The confocal laser endomicroscopy is feasible for measuring more vascular parameters from fresh tumor biopsies than conventional immunohistochemistry alone. Provided new contrast agents will be clinically available, future in vivo use of CLE could lead to identification of novel biomarkers based on the morphometric characteristics of tumor vasculature

PANDEMIC EFFECTS AT PHYSICAL AND PSYCHOSOCIAL LEVEL OF THE ATHLETES

The pandemic COVID-19 has globally affected the physical activity behavior, forcing many people to isolate themselves for a long period of time. These actions caused and increased sedentary behaviors such as excessive sitting or using mobile devices. The lockdown and sedentary behavior have affected the health status and decreased the physical fitness, weakening one’s body and inducing a low immunological response. The aim of the study was to determine how elite handball players were affected at physical and mental during the restrictions imposed by the spreading of the SARS - CoV - 2 virus. A questionnaire-based survey was used to conduct the study. For the questionnaire design we used Likert style with three or five level items. The participants voluntarily consented to anonymously participate in our study before completing the questionnaire. The participants were informed that the data would be used only for scientific purpose. The results of our study suggest that pandemic negatively influenced the sport preparation of the handball players due the fact that subjects trained themselves for a period of over 2 months and that meant a reduction of the physical activity (influencing the physical fitness level) to half comparing to a collective preparation for competition. At mental level more than 2/3 felt an increased level of anxiety due to the pandemic, the way that their life was changed and worries concerning their personal and professional future. This period of incertitude had a negative impact at mental level confirming our hypothesis. REZUMAT. Efecte pandemice la nivel fizic și psihosocial ale sportivilor. Pandemia COVID-19 a afectat la nivel global activitatea fizică, forțând mulți oameni să se izoleze pentru o perioadă lungă de timp. Aceste acțiuni au cauzat și au amplificat comportamentele sedentare, cum ar fi lipsa de activitate sportivă sau utilizarea dispozitivelor mobile. Restricționarea ieșirii din case și comportamentul sedentar au afectat starea de sănătate și au scăzut condiția fizică, slăbind organismul și inducând un răspuns imunologic scăzut. Scopul studiului a fost de a determina modul în care jucătorii de handbal de elită au fost afectați fizic și psihic în timpul restricțiilor impuse de răspândirea virusului SARS - CoV - 2. Pentru realizarea studiului folosit metoda anchetei pe bază de chestionar. Pentru proiectarea chestionarului am folosit scala Likert cu trei sau cinci itemi de nivel. Participanții au consimțit voluntar să participe în mod anonim la studiul nostru înainte de a completa chestionarul. Participanții au fost informați că datele vor fi utilizate numai în scop științific. Rezultatele studiului nostru sugerează că pandemia a influențat negativ pregătirea sportivă a jucătorilor de handbal din cauza faptului că subiecții s-au antrenat singuri pentru o perioadă de peste 2 luni și asta a însemnat o reducere a activității fizice (influențând nivelul de fitness) la jumătate comparativ cu pregătirea colectivă pentru competiție. La nivel mental, mai mult de 2/3 au simțit un nivel crescut de anxietate din cauza pandemiei, a modului în care le-a fost schimbată viața și a îngrijorărilor cu privire la viitorul lor personal și profesional. Această perioadă de incertitudine a avut un impact negativ la nivel mental confirmând ipoteza noastră. Cuvinte cheie: pandemie, antrenament, handbal, comunicare, echipă Received 2022 November 09; Revised 2023 January 21; Accepted 2023 January 24; Available online 2023 May 30; Available print 2023 June 30

Surgical Implications in the Pathology of Diabetes Mellitus – Review of the Literature

Diabetes mellitus brings together several syndromes, all burdened by a high complexity and with the potential to generate vital impairment. The large number of complications result from the association of high blood glucose level with vascular damage, neuropathy, poor healing and overall increased atherosclerosis process. The clinical manifestation of these complications involves a wide range of manifestations from simple lesions to complex pathology, many of them requiring surgical treatment. Surgical implications of diabetes mellitus include diabetic foot syndrome, soft tissue infections, renal impairment and abdominal pathology