Correlation between the presence of metals with potential for intoxication, omega 3 deficiency, increased omega 6: omega 3 ratio and their associated symptoms

Objectives. The study aims to determine the correlation between the presence of heavy metals with intoxication potential (mercury, aluminum, arsenic), increasing the values for the omega 6: omega 3 ratio, decreasing the concentration of omega 3 and it’s impact on health. Another objective of this study is the use of an integrated protocol, developed by an interdisciplinary team, based on a customized alignment program and a treatment plan. Materials and methods. We evaluated in a retrospective observational study, 77 patients who came to the Nutribalance Clinic between September 2017 and December 2019, with specific symptoms of intoxication with toxic metals, especially mercury, aluminum, arsenic and omega 3 deficiencies. The manifested symptoms required a complete set of blood tests for each sub-ject in the study group, tests that showed the presence of one, two and three toxic metals in the case of all 77 subjects. The interdisciplinary team developed a personalized treatment and diet plan, monitoring the evolution on the symptoms initially manifested by each subject. Outcomes. The results of this study shows the beneficial impact of the personalized diet plan and supplements used on the decrease in omega 6: omega 3 ratio, the significant increases in omega 3 which support the detoxification process of heavy metals and a significant improvement in the symptoms of each patient. Conclusions. This study reveals that the process of chelating or detoxifying heavy metals is a complex one and that implies the presence of a complementarity between food and nutritional supplement therapy, avoiding one single direction, as results can be obtained for a short or insignificant period of time

The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population

The insulin -23Hph and IGF2 Apa polymorphisms were genotyped in Romanian patients with T1DM (n = 204), T2DM (n = 215) or obesity (n = 200) and normoponderal healthy subjects (n = 750). The genotypes of both polymorphisms were distributed in concordance with Hardy-Weinberg equilibrium in all groups. The -23Hph AA genotype increased the risk for T1DM (OR: 3.22, 95%CI: 2.09-4.98, p < 0,0001), especially in patients without macroalbuminuria (OR: 4.32, 95%CI: 2.54-7.45, p < 0,0001). No other significant association between the alleles or genotypes of insulin -23Hph and IGF2 Apa and diabetes or obesity was identified

Metabolic Disorders in Menopause and their Correction

Menopause represents a complex period in the women’s life. Several disorders of nutrition and metabolism are accompanying it. The information on this topic is increasing.The carbohydrate disturbances include impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM), but not only. The estrogen deficiency could be an essential contributor to the process of diabetogenesis. Other significant factors for the risk of T2DM are: ageing, obesity (with increasing incidence after menopause), lowering of physical activity, smoking, drinking, some drugs a.s.o.Unfortunately, there are in the scientific literature a number of controversies regarding the relation menopause – diabetes. For instance, an important American study (Diabetes Prevention Program) pointed out that natural menopause did not associate with an increased risk of diabetes and did not influence the answer to the preventive strategy. On the other hand, a large European trial (EPIC – InterAct Study) concluded that early menopause has produced a higher risk for T2DM.Referring to the control of diabetes in the menopause period, many studies emphasize on diet and improving lifestyle, with a major role of physical activity. It is interesting that metformin use in postmenopausal women with diabetes was associated with a lower incidence of invasive breast cancer.Hormone Replacement Therapy (HRT), proposed for the correction of menopause, seems not to be adequate for the women with T2DM.The increase in abdominal and, more particularly, visceral fat accumulation, is associated in menopause with a higher risk of developing an atherogenic lipid profile and an insulin-resistant state.Elevation of total cholesterol, LDL-cholesterol, triglycerides and lipoprotein (a) levels and lowering of HDL-cholesterol levels are observed in the menopause.There is an association between postmenopausal status and a substantial risk of the metabolic syndrome.The cardiovascular risk is also significantly modified.These disorders have a major impact on the quality and duration of life. Their control is in increasing attention of the medical staf