14 research outputs found
Topics on Crises in Electronic Media in Croatia
One of the most important elements in emergency situations and catastrophes is information. It often stands in a very small number, particularly when there is the highest need for it. Mass media is the main link of services responding to emergency situations and disasters to general public. To survivors, to public and even to those enabling help, television, radio and newspapers are most often very crucial sources of information about areas hit by disasters. The interest of media, or their lack of interest, in emergency situations and disasters, can affect on the help arriving. The news is creating a Ā»referential frameĀ« which turns events into phenomenon discussed by the public and that way it is, at the same time, the recorder and the product of social realities. Whether the news will be published or not depends on criteria of efficiency, social context, human, political or social interests, news and regularities, all of these things determine the importance of the story or some of its parts to a particular media, and also determine the way in which it will be processed and context in which it will be aired in public
Uloga omjera E2/P u etiologiji fibrocistiÄne bolesti dojke, mastalgije i mastodinije
The aim of the study was to assess the role of the estradiol and progesterone relationship during the late luteal phase and the occurrence of fibrocystic breast disease (FBD). The concentration of estradiol/progesterone was measured in the group of women with FBD as study group (n=50) and control group of women without FBD (n=40). All women had regular ovulation cycles. Blood samples for estradiol (E2), progesterone (P) and prolactin determination were obtained in the morning at 8 am on days 21 and 24 of menstrual cycle. Significant mastalgia and mastodynia history in women with FBD was obtained with yes or no questionnaire. FBD diagnosis was confirmed with ultrasound (size and number of simple cysts). In the control group, a reduced E2/P ratio was noticed from day 21 to day 24 of the cycle (from 14.8Ā±11.5 pg/mL to 9.1Ā±6.1 pg/mL; p<0.05), which was not recorded in the group of women with FBD (study group). Even the slightest disturbance of the E2/P ratio may contribute to the occurrence of FBD with clinical manifestations of mastalgia and mastodynia.Namjera rada je bila ispitati ulogu odnosa estradiola i progesterona za vrijeme lutealne faze ciklusa u pojavljivanju fibrocistiÄne bolesti dojke (FBD). Koncentracija odnosa estradiol/progesteron je bila mjerena u skupini žena s FBD (n=50) (studijska skupina) i u kontrolnoj skupini žena bez FBD (n=40) (kontrolna skupina). Sve su žene imale redovite ovulacijske cikluse. Krvni uzorci estradiola (E2), progesterona (P) i prolaktina odreÄivali su se u 8 h ujutro 21. i 24. dana menstruacijskog cikusa. OdreÄivanje znaÄajnosti mastalgije i mastodinije bila je ispitana upitnikom da/ne. Dijagnoza FBD je bila potvrÄena ultrazvukom dojke (veliÄina i broj jednostavnih cista). U kontrolnoj skupini smanjen odnos E2/P zabilježen je od 21. do 24. dana ciklusa (od 14,8Ā±11,5 pg/mL do 9,1Ā±6,1 pg/mL; p<0,05), za razliku od žena studijske skupine gdje ta promjena nije bila zapažena. Äak i mala promjena odnosa E2/P može doprinijeti nastanku FBD s kliniÄkim manifestacijama mastalgije i mastodinije
Individualizacija magistralnog hormonskog lijeÄenja kod bolesnice s kemoterapijom induciranom prijevremenom insuficijencijom jajnika i smanjenom jetrenom funkcijom: prikaz sluÄaja
Although the use of commercially manufactured hormone therapy (HT) to treat menopausal symptoms has declined during the past 12 years, the use of custom compounded HT seems to have increased. A 39-year-old woman with refractory anemia sustained premature ovarian insufficiency following allogeneic stem cell transplantation. After systemic biologic treatment (azacitidine) and corticosteroid therapy, besides extreme climacteric symptoms (Green Climacteric Scale, 59) and impaired quality of life, she also had elevated liver enzymes. Therefore, she was not a candidate for oral HT. Treatment was started with 17-beta estradiol patch 0.5 mg (Climara) together with micronized progesterone intravaginally, 2x100 mg (Utrogestan) for 3 months. She was not satisfied, so the custom compound HT started with 17-beta estradiol 0.5 mg gel 2x/day and micronized progesterone in liposomal gel 100 mg/daily. She was much better but she complained of low libido, decreased sex drive and emotional instability, so 1% testosterone gel was added. Now she was completely satisfied, Green Climacteric Scale was 8 and liver enzymes were normal. In conclusion, custom compound HT has the possibility of tailoring and adjusting therapy to the individual need, which has been the everlasting goal in menopause medicine and should be a good option for special clinical cases.Premda je upotreba komercijalno pripravljene hormonske terapije u lijeÄenju klimakteriÄnih simptoma u posljednjih 12 godina u padu, Äini se da je upotreba magistralnih hormonskih pripravaka u porastu. Žena u dobi od 39 godina s refraktornom anemijom doživjela je prijevremenu insuficijenciju jajnika nakon transplantacije matiÄnih stanica. Nakon sistemskog bioloÅ”kog lijeÄenja azacitidinom i kortikosteroidima, uz izrazite klimakteriÄne tegobe (Greenov indeks 59) i smanjenu kvalitetu
života imala je poviÅ”ene jetrene enzime. Zbog toga nije bila kandidat za oralnu hormonsku terapiju. ZapoÄeto je lijeÄenje 17-beta estradiolom u obliku naljepka od 0,5 mg (Climara) zajedno s mikroniziranim progesteronom intravaginalno 2x100 mg (Utrogestan) kroz 3 mjeseca. Nije bila zadovoljna terapijom pa su joj propisani magistralno pripravljeni hormoni. ZapoÄelo se s primjenom 17-beta estradiola u obliku 0,5 mg gela 2x/dan i mikroniziranog progesterona u liposomalnom gelu 100 mg/dnevno. Bolje se je osjeÄala, ali joÅ” uvijek se žalila na smanjeni libido i emocionalnu nestabilnost pa je dodan 1%
testosteron. Sad je bila potpuno zadovoljna terapijom, Greenova klimakterijska ljestvica bila je 8, a jetreni enzimi su se normalizirali.
U zakljuÄku, magistralni hormonski pripravci pružaju moguÄnost titracije i prilagoÄavanja terapije individualnim potrebama, Å”to je stalni cilj u menopauzalnoj medicini i mogao bi biti dobra moguÄnost za posebne sluÄajeve
Croatian Cartographic Data Model, Creation and Implementation
Hrvatski projekt āIzradba kartografskog modela podatakaā (KMP) izraÄen je u okviru izradbe projekta STOKIS (DGU, 1995, Službeni topografski i kartografski informacijski sustav). Kartografski model podataka izraÄen je potpuno konformno s CROTIS-om (Hrvatski Topografski Informacijski Sustav). OmoguÄeno je generiranje kartografskih podataka iz topografskih podataka. Klasifikacija podatka je uslijedila iz logiÄkog grupiranja objekata sadržanih u kartografiji ovisno o geometriji, kategoriji, tipu i svojstvu svakog objekta. Kartografski model podataka opisuje strukturu kartografske baze podataka i sve atribue, kategorije, tipove i polja. Opis geometrije i prijenos podataka napravljen je u skladu s ISO-normama, preporuÄenih od strane tehniÄkog odbora ISO/TC211, zaduženog za geografske informacije i geomatiku te OpenGIS konzorcija. SljedeÄi korak je direktna implementacija vektorskog modela koji sadrži grafiÄke i alfanumeriÄke elemente. Kartografski kljuÄ ostao je identiÄan TK25 i kartama ostalih mjerila.Croatian project Cartographic Data Model (KMP) has been started as a component of the STOKIS (SGA, 1995, Official Topographic and Cartographic Information System) project. The cartographic data model conforms to CROTIS (Topographic Information System of the Republic of Croatia). It enables the generation of the cartographic database from topographic one. Classification of data is performed by logical grouping of objects and depends on geometry, type and properties of features. The cartographic data model describes structure of cartographic database and all attributes, categories, types and fields. Description of geometry and exchange of data is performed according to the specification of ISO Standards, adapted by Technical Committee ISO/TC 211, Geographic information/Geomatics and OpenGIS Consortium. Creation of the cartographic data model is the basis for the creation of cartographic database. The next step is direct implementation of vector model that contains graphic and alphanumeric elements. The cartographic key must stay identical to TK25 and maps of other scales
NEW ASPECTS IN DIAGNOSIS AND TREATMENT OF OSTEOPOROSIS
Background. Osteoporosis is a disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk. In prevention and treatment of osteoporosis, the issue of main interest is prevention of fractures, especially prevention of the first fracture. In recent years, especially after the result of the randomised control trial of Womenās Health Initiative (WHI) was published in the literature, attitudes toward prevention and treatment of osteoporosis have been changed. Hormonal replacement therapy (HRT) use is no longer recommended as a first line treatment, but only a possibility for treatment perimenopausal and early-postmenopausal women with climacteric symptoms and increased risk for fracture, only when therapy benefits outweigh the risks. Today, independent risk factors are taken into account in treatment of osteoporosis, with or without BMD measurement, but including the 10-years risk probability (FRAX ā fracture risk assessment tool). There are new possibilites for treatment including a Osteoprotegerin (OPG)/ Receptor Activator of Nuclear factor kappa B (RANK) / Receptor Activator of Nuclear factor kappa B ligand (RANKL) remodelation bone model.
Conclusions. Treatment of osteoporosis is going to be a complex task including all fracture risk factors, polypragmazia which is very common in elderly patents, adherence problems, and last but not least, the economic aspects
Radiofrequency as the New Opportunity in Treating Overactive Bladder and Urge Urinary IncontinenceāA Single-Arm Pilot Study
Background and Objectives: Until now, overactive bladder (OAB) with or without urge urinary incontinence (UUI) has been treated mainly in two ways: with behavioral methods and patient education, or using antimuscarinic drugs and/or beta-3 adrenergic receptor agonists. Unfortunately, these drugs may cause side effects in some women or are insufficiently effective, so patients abandon them. Therefore, in this pilot study, radiofrequency was evaluated as a new option in the treatment of OAB and UUI. Materials and Methods: Nineteen patients were enrolled in this pilot study using radiofrequency (RF), where the level of OAB and UUI was assessed using the validated ICIQ-OAB questionnaire. RF was applied four times for 20 min, once a week. Two weeks after treatment, the level of OAB and UUI was reassessed and processed statistically and the treatment effect evaluated. Results: Using the ICIQ-OAB, the severity of OAB and UUI was assessed: 0ā3 mild symptoms; 4ā7 moderate symptoms; 8ā11 severe symptoms; 12ā16 very severe symptoms. Before treatment, 10.5% of patients had mild symptoms, 21.1% moderate symptoms, 63.2% severe symptoms and 5.3% very severe symptoms. After treatment, 42.9% had mild symptoms, 50% moderate symptoms and 7% severe OAB and UUI symptoms. All four main symptomsāfrequency, nocturia, urgency and incontinenceādecreased statistically significantly, with the best results being found in urgency (p = 0.002). Conclusions: Based on this pilot study, RF seems a very promising method in the treatment of OAB and UUI. To extend our initial findings, it is necessary to perform a prospective, randomized and placebo-controlled study in order to obtain reliable results and to determine for how long one set of treatment maintains the results obtained immediately after the end of that treatment. In this way, we may determine how often the treatment needs to be repeated, if necessary, and when
Laser Therapy in the Treatment of Female Urinary Incontinence and Genitourinary Syndrome of Menopause: An Update
Vaginal birth trauma is the leading cause of stress urinary incontinence (SUI) in women. Also, the process of ageing and hormonal deprivation in postmenopause alters the metabolism of connective tissues and decreases collagen production leading to pelvic floor dysfunction. Noninvasive treatment is recommended as first-line management of urinary incontinence (UI) in women. Surgical procedures are more likely to be implemented to cure UI but are associated with more adverse events. Sex hormone deficiency affects changes also in the lower urinary tract where estrogens are the main regulators of physiological functions of the vagina. In the last decade, laser treatment of SUI and of the genitourinary syndrome of menopause (GSM) has been shown a promising treatment method in peer-reviewed literature. This reviewās aim is to present the evidence-based medical data and laser treatment of SUI and GSM in an outpatient setting to be a good treatment option, regarding short-term as well as long-term follow-ups. Long-term follow-up studies are needed to confirm that laser treatment is a good, painless outpatient procedure with no side effects in postmenopausal women
Genetska etiologija prijevremene insuficijencije jajnika
Primary premature ovarian insufficiency (PPOI) is characterized by hypergonadotropic amenorrhea and hypoestrogenism in women under 40 years of age. PPOI incidence is 1:10,000 in women aged 18-25, 1:1000 in women aged 25-30 and 1:100 in women aged 35-40. In 10%-28% of cases, PPOI causes primary and in 4%-18% secondary amenorrhea. The process is a consequence of accelerated oocyte atresia, diminished number of germinated cells, and central nervous system aging. Specific genes are responsible for the control of oocyte number undergoing the ovulation process and the time to cessation of the reproductive function. A positive family history of PPOI is found in 15% of women with PPOI, indicating the existing genetic etiology. Primary POI comprises genetic aberrations linked to chromosome X (monosomy, trisomy, translocation, deletion) or to autosomal chromosome. Secondary POI implies surgical removal of ovaries, chemotherapy and radiotherapy, and infections. Diagnostic criteria include follicle stimulating hormone level >40 IU/L and estradiol level
<50 pmol/L.Primarna prijevremena insuficijencija jajnika (PPIJ) je sindrom koji je obilježen hipergonadotropnom amenorejom i hipoestrogenizmom. Incidencija PPIJ je 1:10.000 kod žena starosti 18-25 godina, 1:1000 kod žena starosti 25-30 godina i 1:100 kod žena starosti 35-40 godina. U 10%-28% sluÄajeva PPIJ je uzrok primarnih, a u 4%-18% sekundarnih amenoreja. Bolest nastaje kao posljedica ubrzanog procesa atrezije oocita, smanjenja broja germinativnih stanica i starenja srediÅ”njeg živÄanog sustava. SpecifiÄni geni su odgovorni za kontrolu broja oocita koji prolaze proces ovulacije i vrijeme prekida reproduktivne funkcije. Pozitivna obiteljska anamneza PPIJ naÄena je u oko 15% žena s PPIJ, Å”to ukazuje na postojanje odreÄene genetske etiologije. Primarna insufi cijencija jajnika (PIJ) dijeli se na primarnu i sekundarnu. U primarnu PIJ spadaju genetske aberacije vezane za kromosom X (monosomije, trisomije, translokacije, delecije) ili one vezane za autosomne kromosome. U sekundarnu PIJ spadaju kirurÅ”ko odstranjenje jajnika, lijeÄenje kemoterapijom i radioterapijom te infekcije. Simptomi su razdražljivost, nemir, gubitak libida, depresija, nesanica, dekoncentracija, napadaji vruÄine, poviÅ”enje tjelesne težine, suhoÄa vagine i drugih sluznica. Kriteriji za dijagnozu su folikulostimulirajuÄi hormon viÅ”i od 40 IJ/L i estradiol (E2) niži od 50 pmol/L kod žena mlaÄih od 40 godina
Inkontinencija mokraÄe - od djetinjstva do starosti
Urinary incontinence (UI) is a condition that affects patients of all ages, starting
with childhood. There are two peaks in its incidence, i.e., in childhood and another one in patients
over 40 years of age, which increases continuously with patient age. It is a condition recognized by the
World Health Organization as a set of diseases (International Classification of Diseases, ICD-10),
and the International Classification of Functionality recognizes the associated extreme disablement.
UI is a major health problem affecting the lives of an estimated 400 million persons worldwide. The
global aging of the population will cause rise in the incidence of UI in the future. It is expected that
UI itself will become a serious health and social burden for both patients and health service providers.
UI can be an isolated problem, or it can be associated and/or aggravated by any associated disorder
affecting the nervous system such as myelomeningoceles, Parkinsonās disease or stroke. UI often affects
the patient daily life, and it can have repercussions on their physical, financial, social, and emotional
well-being. At last, it has a negative influence on their sexual health.Inkontinencija mokraÄe (IM) je stanje koje pogaÄa osobe svih dobnih skupina poÄevÅ”i od djetinjstva. Postoje dva vrhunca
incidencije i to u djetinjstvu, a drugi u bolesnika starijih od 40 godina, koji se stalno poveÄava s dobi bolesnika. To je stanje
koje Svjetska zdravstvena organizacija prepoznaje kao skup bolesti (MeÄunarodna klasifikacija bolesti, MKB-10), a MeÄunarodna
klasifikacija funkcionalnosti prepoznaje pridruženu ekstremnu onesposobljenost. IM glavni je zdravstveni problem
koji utjeÄe na živote oko 400 milijuna ljudi Å”irom svijeta. Globalno starenje stanovniÅ”tva uzrokovat Äe porast uÄestalosti IM u
buduÄnosti. OÄekuje se da Äe i sama IM postati ozbiljno zdravstveno i socijalno optereÄenje za bolesnike i pružatelje zdravstvenih
usluga. IM može biti izolirani problem ili može biti povezana s i/ili pogorÅ”ana bilo kojim povezanim poremeÄajem koji
pogaÄa živÄani sustav, kao Å”to su mijelomeningocele, Parkinsonova bolest, moždani udar itd. IM Äesto utjeÄe na svakodnevni
život bolesnika i može imati posljedice na njihovo fiziÄko, financijsko, socijalno i emocionalno stanje. Napokon ima negativan
utjecaj na njihovo seksualno zdravlje
The Role of E2/P Ratio in the Etiology of Fibrocystic Breast Disease, Mastalgia and Mastodynia
The aim of the study was to assess the role of the estradiol and progesterone relationship during the late luteal phase and the occurrence of fibrocystic breast disease (FBD). The concentration of estradiol/progesterone was measured in the group of women with FBD as study group (n=50) and control group of women without FBD (n=40). All women had regular ovulation cycles. Blood samples for estradiol (E2), progesterone (P) and prolactin determination were obtained in the morning at 8 am on days 21 and 24 of menstrual cycle. Significant mastalgia and mastodynia history in women with FBD was obtained with yes or no questionnaire. FBD diagnosis was confirmed with ultrasound (size and number of simple cysts). In the control group, a reduced E2/P ratio was noticed from day 21 to day 24 of the cycle (from 14.8Ā±11.5 pg/mL to 9.1Ā±6.1 pg/mL; p<0.05), which was not recorded in the group of women with FBD (study group). Even the slightest disturbance of the E2/P ratio may contribute to the occurrence of FBD with clinical manifestations of mastalgia and mastodynia