Danielle Jacquart et Claude Thomasset. Sexualité et savoir médical au Moyen Age ; Paris : Presses universitaires de France, 1985 ; in-8°, 271 pages [Les chemins de l'histoire.]

Daliphard Marc. Danielle Jacquart et Claude Thomasset. Sexualité et savoir médical au Moyen Age ; Paris : Presses universitaires de France, 1985 ; in-8°, 271 pages [Les chemins de l'histoire.]. In: Bibliothèque de l'école des chartes. 1987, tome 145, livraison 1. pp. 248-249

Danielle Jacquart et Claude Thomasset. Sexualité et savoir médical au Moyen Age ; Paris : Presses universitaires de France, 1985 ; in-8°, 271 pages [Les chemins de l'histoire.]

Daliphard Marc. Danielle Jacquart et Claude Thomasset. Sexualité et savoir médical au Moyen Age ; Paris : Presses universitaires de France, 1985 ; in-8°, 271 pages [Les chemins de l'histoire.]. In: Bibliothèque de l'école des chartes. 1987, tome 145, livraison 1. pp. 248-249

t(1;3)(p36;q21)

Review on t(1;3)(p36;q21), with data on clinics, and the genes involved

Pancytopénie sévère secondaire à un déficit en folates en dépit d’un dosage de folatesérythrocytaires normal

International audienceWe report the case of an alcoholic patient with severe pancytopenia with lowplasma folate level but normal erythrocyte folates and cobalamin levels. The bone marrow smear concluded to a pancytopenia due to folates and/or cobalamin deficiency. Severe pancytopenia due to acute plasma folate deficiency can be observed despite normal erythrocyte folates level which reflects the organism’s folates store.Nous rapportons un cas de pancytopénie sévère avec dosage en folates sériques isolément bas contrastant avec des folates érythrocytaires et vitamine B12 normaux, chez un patient alcoolique. Le myélogramme montrait un aspect de moelle carentielle en ces vitamines. Ce cas met en lumière la possibilité de survenue d’une pancytopénie sévère secondaire à une carence en folates, en dépit d’un dosage normal de folates érythrocytaires, qui est un indicateur des apports en folates des 3 derniers mois (durée de vie du globule rouge) et donc des réserves de l’organisme

Residual Disease in B-Cell Chronic Lymphocytic-Leukemia Patients and Prognostic Value

Twenty-two B-cell chronic lymphocytic leukemia (CLL) patients were investigated to evaluate residual disease in clinico-hematological remission. Residual disease was determined by monotypy of surface light chain expression and by dual-color staining with CD5 and CD19 markers. Samples were analyzed on flow cytometer. Total CD19+ cells above 25%, the CD5+CD19+/total CD19+ cells ratio above 0.25, clonal excess above 0.4 were considered positive for residual disease. According to these immunological criteria, only four cases achieved phenotypic remission. Our data confirm that dual marker analysis is more sensitive than clonal excess and may predict an early relapse. Ig gene rearrangements were studied by Southern blot analysis using IGHJ and IGKC probes in fifteen cases. All 12 cases that retained a detectable rearrangement displayed a phenotypic residual disease. Conversely, in two cases, DNA analysis failed to detect the residual disease characterized by flow cytometry. In conclusion, this study suggests that in B-CLL, dual marker analysis is sensitive in predicting an early relapse in sequential evaluations of residual disease, whereas rearranged bands are undetectable when the proportion of malignant cells is low

Residual Disease in B-Cell Chronic Lymphocytic-Leukemia Patients and Prognostic Value

Twenty-two B-cell chronic lymphocytic leukemia (CLL) patients were investigated to evaluate residual disease in clinico-hematological remission. Residual disease was determined by monotypy of surface light chain expression and by dual-color staining with CD5 and CD19 markers. Samples were analyzed on flow cytometer. Total CD19+ cells above 25%, the CD5+CD19+/total CD19+ cells ratio above 0.25, clonal excess above 0.4 were considered positive for residual disease. According to these immunological criteria, only four cases achieved phenotypic remission. Our data confirm that dual marker analysis is more sensitive than clonal excess and may predict an early relapse. Ig gene rearrangements were studied by Southern blot analysis using IGHJ and IGKC probes in fifteen cases. All 12 cases that retained a detectable rearrangement displayed a phenotypic residual disease. Conversely, in two cases, DNA analysis failed to detect the residual disease characterized by flow cytometry. In conclusion, this study suggests that in B-CLL, dual marker analysis is sensitive in predicting an early relapse in sequential evaluations of residual disease, whereas rearranged bands are undetectable when the proportion of malignant cells is low