Microelectrode for in vivo real-time detection of NO

PubMed ID: 16291265Nitric oxide (NO) is gaining importance with its diverse spectrum of clinic effects. However, there is still a need for an ideal sensor to monitor its concentration in tissue. An ideal sensor should not interfere with the ongoing physiological process, while making fast, reliable, and repeatable measurements. We have designed a microelectrode for electrochemical NO measurement from tissue with relatively low interference and reliable results upon calibration. Details of electrode preparation and calibration procedure are explained along with an experiment to monitor effects of photodynamic therapy. Copyright 2005, Elsevier Inc. All rights reserved

Effects of methyl prednisolone, dimethyl sulphoxide and naloxone in experimental spinal cord injuries in rats

PubMed ID: 2907111The effects of methyl prednisolone (MPD), dimethyl sulphoxide (DMSO), and naloxone were examined in 38 albino rats after making an impact spinal cord injury on the midthoracic segments with a modified Allen's weight dropping trauma method. Somatosensorial evoked potentials (SEPs) were recorded before and 12 h and 14 d after the injury from epidurally inserted electrodes on the parietal cortex with sciatic nerve stimulations. Lower extremity motor functions of the animals were also examined. It may be concluded that in this study model, DMSO has a moderate effect which can be demonstrated clinically and through SEPs. Naloxone has no effect on the clinical outcome but causes reasonable improvement electrophysiologically

Long survival results with repeated biochemotherapy (bucladesine plus fotemustine) in de novo GBM patients

2nd Quadrennial Meeting of the World-Federation-of-Neuro-Oncology/6th Meeting of the European-Association-for-Neur-Oncology -- MAY 05-08, 2005 -- Edinburgh, SCOTLANDWOS: 000230463900164World Federat Neuro Oncol, European Assoc Neuro Onco