2 research outputs found
Intramolecular C(sp<sup>3</sup>)–H Bond Activation Reactions of Low-Valent Cobalt Complexes with Coordination Unsaturation
Intramolecular CÂ(sp<sup>3</sup>)–H bond activation
reactions mediated by low-valent cobalt, both CoÂ(I) and Co(0), have
been observed in the reactions of the three-coordinate cobalt complex
[CoÂ(IMes)<sub>2</sub>Cl] (IMes = 1,3-dimesitylimidazol-2-ylidene)
with alkylation reagents and sodium amalgam. The reactions with alkylation
reagents gave [CoÂ(IMes)Â(IMes′)Â(N<sub>2</sub>)], featuring a
metalated IMes′ anion, whereas the one-electron-reduction reaction
afforded [CoÂ(IMes′)<sub>2</sub>]. The CoÂ(II) complex can react
with CO, isocyanide, and a diazo compound to furnish interesting cobalt
complexes bearing functionalized N-heterocyclic carbene ligands. The
establishment of these conversions demonstrates the capability of
low-valent cobalt with coordination unsaturation to mediate CÂ(sp<sup>3</sup>)–H bond activation and functionalization
Table1_Long-term outcomes of radiofrequency ablation vs. partial nephrectomy for cT1 renal cancer: A meta-analysis and systematic review.xlsx
BackgroundPartial nephrectomy (PN) is one of the most preferred nephron-sparing treatments for clinical T1 (cT1) renal cancer, while radiofrequency ablation (RFA) is usually used for patients who are poor surgical candidates. The long-term oncologic outcome of RFA vs. PN for cT1 renal cancer remains undetermined. This meta-analysis aims to compare the treatment efficacy and safety of RFA and PN for patients with cT1 renal cancer with long-term follow-up of at least 5 years.MethodThis meta-analysis was performed following the PRISMA reporting guidelines. Literature studies that had data on the comparison of the efficacy or safety of RFA vs. PN in treating cT1 renal cancer were searched in databases including PubMed, Embase, Web of Science, and the Cochrane Library from 1 January2000 to 1 May 2022. Only long-term studies with a median or mean follow-up of at least 5 years were included. The following measures of effect were pooled: odds ratio (OR) for recurrence and major complications; hazard ratio (HR) for progression-free survival (PFS), cancer-specific survival (CSS), and overall survival (OS). Additional analyses, including sensitivity analysis, subgroup analysis, and publication bias analysis, were also performed.ResultsA total of seven studies with 1,635 patients were finally included. The treatment efficacy of RFA was not different with PN in terms of cancer recurrence (OR = 1.22, 95% CI, 0.45–3.28), PFS (HR = 1.26, 95% CI, 0.75–2.11), and CSS (HR = 1.27, 95% CI, 0.41–3.95) as well as major complications (OR = 1.31, 95% CI, 0.55–3.14) (P > 0.05 for all). RFA was a potential significant risk factor for OS (HR = 1.76, 95% CI, 1.32–2.34, P ConclusionThis is the first meta-analysis that focuses on the long-term oncological outcomes of cT1 renal cancer, and the results suggest that RFA has comparable therapeutic efficacy with PN. RFA is a nephron-sparing technique with favorable oncologic efficacy and safety and a good treatment alternative for cT1 renal cancer.</p