15 research outputs found

    Flow of enrollment and retention of the study participants.

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    <p>Flow of enrollment and retention of the study participants.</p

    Bivariate association between participant's characteristics and the uptake of A (H1N1) influenza vaccine.

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    <p>*p-values were based on χ<sup>2</sup> test or Fisher's Exact test.</p>†<p>Underlying diseases included chronic respiratory diseases, chronic metabolic diseases, chronic heart diseases, liver diseases, kidney diseases, and immunodeficiency diseases.</p>‡<p>High-risk groups included people with an underlying disease, pregnant women, children age five years or younger, and elderly people aged 65 years or older.</p>§<p>School-going children included primary school students to university students.</p

    Characteristics of the participants at baseline and follow-up.

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    <p>SD denotes standard deviation.</p><p>*Exchange rate: US$ 1  =  ¥90.</p>†<p>Underlying diseases included chronic respiratory diseases, chronic metabolic diseases, chronic heart diseases, liver diseases, kidney diseases, and immunodeficiency diseases.</p>‡<p>High-risk groups included people with an underlying disease, pregnant women, children age five years or younger, and elderly people aged 65 years or older.</p>§<p>School-going children included primary school students to university students.</p

    Potential Biomarker Peptides Associated with Acute Alcohol-Induced Reduction of Blood Pressure

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    <div><p>The purpose of this study was to explore the peptides that are related to acute reduction of blood pressure after alcohol drinking. Venous blood was collected from male healthy volunteers before and after drinking white wine (3 ml/kg weight) containing 13% of ethanol. Peptidome analysis for serum samples was performed using a new target plate, BLOTCHIP<sup>®</sup>. Alcohol caused significant decreases in systolic and diastolic blood pressure levels at 45 min. The peptidome analysis showed that the levels of three peptides of <i>m/z</i> 1467, 2380 and 2662 changed significantly after drinking. The <i>m/z</i> 1467 and 2662 peptides were identified to be fragments of fibrinogen alpha chain, and the <i>m/z</i> 2380 peptide was identified to be a fragment of complement C4. The intensities of the <i>m/z</i> 2380 and <i>m/z</i> 1467 peptides before drinking were associated with % decreases in systolic and diastolic blood pressure levels at 45 min after drinking compared with the levels before drinking, while there were no significant correlations between the intensity of the <i>m/z</i> 2662 peptide and % decreases in systolic and diastolic blood pressure levels after drinking. The <i>m/z</i> 1467 and 2380 peptides are suggested to be markers for acute reduction of blood pressure after drinking alcohol.</p></div

    Changes in systolic (A) and diastolic (B) blood pressure levels after drinking alcohol.

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    <p>Blood pressure was measured just before dinking and at 45 min and 2–3 hr after drinking. Means ± standard errors of blood pressure levels are shown. Asterisks denote significant differences from the levels before drinking (**, <i>p</i> < 0.01).</p
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