Crystalline chiral condensates off the tricritical point in a generalized Ginzburg-Landau approach

We present an extensive study on inhomogeneous chiral condensates in QCD at finite density in the chiral limit using a generalized Ginzburg-Landau (GL) approach. Performing analyses on higher harmonics of one-dimensionally (1D) modulated condensates, we numerically confirm the previous claim that the solitonic chiral condensate characterized by Jacobi's elliptic function is the most favorable structure in 1D modulations. We then investigate the possibility of realization of several multidimensional modulations within the same framework. We also study the phase structure far away from the tricritical point by extending the GL functional expanded up to the eighth order in the order parameter and its spatial derivative. On the same basis, we explore a new regime in the extended GL parameter space and find that the Lifshitz point is the point where five critical lines meet at once. In particular, the existence of an intriguing triple point is demonstrated, and its trajectory consists of one of those critical lines.Comment: 17 pages, 20 eps figures; (v2) corrected an error in computation of eighth order coefficients; (v3) typos corrected, version to appear in Phys. Rev.

Scalar field perturbation on six-dimensional ultra-spinning black holes

We have studied the scalar field perturbations on six-dimensional ultra-spinning black holes. We have numerically calculated the quasinormal modes of rotating black holes. Our results suggest that such perturbations are stable.Comment: 8 pages, 6 figures; v2:typo corrected; v3:ref. corrected; v4:revise

Development of Flat Tube Heat Exchanger for Heat Pump Air Conditoner

We developed a new type of a heat pump outdoor unit using an aluminum flat tube heat exchanger in order to improve the energy saving capability of an air conditioner. There are several difficulties in keeping a desired drainage performance, frost formation performance, as well as even distribution of refrigerant, when applying the flat tube heat exchanger to heat pump outdoor units. In order to achieve the same drainage performance and the frost formation performance as those of conventional heat exchangers, we have adopted new plate fins with ellipse cutouts. Flat tubes were inserted in the ellipse cutouts, and the slit position on a plate fin was properly adjusted. In order to achieve the even distribution of refrigerant, an aluminum distributor and 3-way pipes were installed to the evaporator. In this report, first we describe features of the flat tube heat exchanger. Next, we present and explain experimental results of the air-side heat transfer coefficient and the air-side pressure drop on the condition of dry, wet, and frost state respectively. Moreover, we present experimental results of the total heat transfer performance, including the refrigerant performance, under the conditions of the condensation and the evaporation. Finally, we explain the heat transfer performance and the effect of the flat tube heat exchanger to a conventional one in the case that the developed heat exchanger was mounted in heat pump outdoor unit

Gastric Mucosal Changes Caused by Lugol's Iodine Solution Spray: Endoscopic Features of 64 Cases on Screening Esophagogastroduodenoscopy

Aim. To clarify the endoscopic mucosal change of the stomach caused by Lugol's iodine solution spray on screening esophagogastroduodenoscopy (EGD). Methods. Sixty-four consecutive patients who underwent EGD for esophageal squamous cell carcinoma screening were included in this study. The records for these patients included gastric mucosa findings before and after Lugol's iodine solution was sprayed. The endoscopic findings of the greater curvature of the gastric body were retrospectively analyzed based on the following findings: fold thickening, exudates, ulcers, and hemorrhage. Results. Mucosal changes occurred after Lugol's solution spray totally in 51 patients (80%). Fold thickening was observed in all 51 patients (80%), and a reticular pattern of white lines was found on the surface of the thickened gastric folds found in 28 of the patients (44%). Exudates were observed in 6 patients (9%). Conclusion. The gastric mucosa could be affected by Lugol's iodine; the most frequent endoscopic finding of this effect is gastric fold thickening, which should not be misdiagnosed as a severe gastric disease

Effect of Visuospatial Attention on the Sensorimotor Gating System

The integration of multiple sensory modalities allows us to adapt to the environment of the outside world. It is widely known that visual stimuli interfere with the processing of auditory information, which is involved in the ability to pay attention. Additionally, visuospatial attention has the characteristic of laterality. It is unclear whether this laterality of visuospatial attention affects the processing of auditory stimuli. The sensorimotor gating system is a neurological process, which filters out unnecessary stimuli from environmental stimuli in the brain. Prepulse inhibition (PPI) is an operational measure of the sensorimotor gating system, which a weaker prestimulus (prepulse), such as a visual stimulus, inhibits the startle reflex elicited by a subsequent robust startling stimulus (pulse) such as a tone. Therefore, we investigated whether the visual stimulus from the left or right visual space affects the sensorimotor gating system in a “rest” task (low attentional condition) and a “selective attention” task (high attentional condition). In the selective attention task, we found that the target prepulse presented in the left and bilateral visual fields suppressed the startle reflex more than that presented in the right visual field. By contrast, there was no laterality of PPI in the no-target prepulse condition, and there was no laterality of PPI in the rest task. These results suggest that the laterality of visuospatial attention affects the sensorimotor gating system depending on the attentional condition. Moreover, the process of visual information processing may differ between the left and right brain

Thick domain walls around a black hole

We discuss the gravitationally interacting system of a thick domain wall and a black hole. We numerically solve the scalar field equation in the Schwarzschild spacetime and obtain a sequence of static axi-symmetric solutions representing thick domain walls. We find that, for the walls near the horizon, the Nambu--Goto approximation is no longer valid.Comment: 18 pages, 11 figures, one reference adde

Type I interferon protects neurons from prions in in vivo models

Infectious prions comprising abnormal prion protein, which is produced by structural conversion of normal prion protein, are responsible for transmissible spongiform encephalopathies including Creutzfeldt-Jakob disease in humans. Prions are infectious agents that do not possess a genome and the pathogenic protein was not thought to evoke any immune response. Although we previously reported that interferon regulatory factor 3 (IRF3) was likely to be involved in the pathogenesis of prion diseases, suggesting the protective role of host innate immune responses mediated by IRF3 signalling, this remained to be clarified. Here, we investigated the reciprocal interactions of type I interferon evoked by IRF3 activation and prion infection and found that infecting prions cause the suppression of endogenous interferon expression. Conversely, treatment with recombinant interferons in an ex vivo model was able to inhibit prion infection. In addition, cells and mice deficient in type I interferon receptor (subunit interferon alpha/beta receptor 1), exhibited higher susceptibility to 22L-prion infection. Moreover, in in vivo and ex vivo prion-infected models, treatment with RO8191, a selective type I interferon receptor agonist, inhibited prion invasion and prolonged the survival period of infected mice. Taken together, these data indicated that the interferon signalling interferes with prion propagation and some interferon-stimulated genes might play protective roles in the brain. These findings may allow for the development of new strategies to combat fatal diseases

Hyperefficient PrP Sc amplification of mouse-adapted BSE and scrapie strain by protein misfolding cyclic amplification technique.

Abnormal forms of prion protein (PrP(Sc)) accumulate via structural conversion of normal PrP (PrP(C)) in the progression of transmissible spongiform encephalopathy. Under cell-free conditions, the process can be efficiently replicated using in vitro PrP(Sc) amplification methods, including protein misfolding cyclic amplification. These methods enable ultrasensitive detection of PrP(Sc); however, there remain difficulties in utilizing them in practice. For example, to date, several rounds of protein misfolding cyclic amplification have been necessary to reach maximal sensitivity, which not only take several weeks, but also result in an increased risk of contamination. In this study, we sought to further promote the rate of PrP(Sc) amplification in the protein misfolding cyclic amplification technique using mouse transmissible spongiform encephalopathy models infected with either mouse-adapted bovine spongiform encephalopathy or mouse-adapted scrapie, Chandler strain. Here, we demonstrate that appropriate regulation of sonication dramatically accelerates PrP(Sc) amplification in both strains. In fact, we reached maximum sensitivity, allowing the ultrasensitive detection of < 1 LD(50) of PrP(Sc) in the diluted brain homogenates, after only one or two reaction rounds, and in addition, we detected PrP(Sc) in the plasma of mouse-adapted bovine spongiform encephalopathy-infected mice. We believe that these results will advance the establishment of a fast, ultrasensitive diagnostic test for transmissible spongiform encephalopathies.The definitive version is available at www.blackwell-synergy.co