mtDNA ancestry, cervical lesions and socio-demographic variables for the Posadas population.

<p>mtDNA ancestry, cervical lesions and socio-demographic variables for the Posadas population.</p

Association analysis between HPV infection and development of cervical lesions.

<p>Association analysis between HPV infection and development of cervical lesions.</p

Multivariate regression analysis for mtDNA, HPV infection and cervical cancer.

<p>Legend: A Forest Plot showing the odds ratio values and 95% confidence intervals for: (A) Model IV—Pap cytology, mtDNA ancestry and HPV infection, adjusted by socio-demographic variables and (B) Model V—Pap cytology, mtDNA haplogroups and HPV infection, adjusted by socio-demographic variables. The x-axis represents the odds ratio (circles, square, others) and 95% confidence intervals (whiskers). The dashed vertical line indicates the OR value of 1. Non-significant values are shown as a small filled circle. Significant values are shown as squares (HPV33), diamonds (other HPV-HR), asterisks (HPV58), triangles (HPV16), inverted triangles (HPV6/11), and unfilled circles (multiple infections), with the OR (CI = 95%) as a legend into the figure. Details about other OR (CI = 95%) and p values are provided in the Supplementary Information (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0190966#pone.0190966.s004" target="_blank">S4</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0190966#pone.0190966.s005" target="_blank">S5</a> Tables). Amerindian ancestry and haplogroup A were not plotted since they were used as a reference values.</p

Frequency of mtDNA haplogroups and phylogroups in the study groups.

<p>Frequency of mtDNA haplogroups and phylogroups in the study groups.</p

Frequency of HPV types in the study groups.

<p>Frequency of HPV types in the study groups.</p

Multivariate regression analysis for mtDNA and cervical cancer.

<p>Legend: A Forest Plot showing odds ratio values and 95% confidence intervals for: (A) Model II—Pap cytology and mtDNA ancestry, adjusted by socio-demographic variables and, (B) Model III—Pap cytology and mtDNA haplogroups, adjusted by socio-demographic variables. The x-axis represents the odds ratio (circles and square) and 95% confidence intervals (whiskers). The dashed vertical line indicates an OR value of 1. Non-significant values are shown as a small circle. Significant values are shown as square, with the OR (CI95%) as a legend into the figure. Details on other OR (CI = 95%) and p values are provided in the Supplementary Information (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0190966#pone.0190966.s002" target="_blank">S2</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0190966#pone.0190966.s003" target="_blank">S3</a> Tables). Amerindian ancestry and haplogroup A were not plotted since they were used as reference values (OR = 1).</p