未来的维度 = The dimension of the future

在本论文中，笔者集中讨论21世纪语境中的“未来”作为一个议题及其参数。对于笔者说来，未来议题，不关乎时间，不是乌托邦的别称。“未来”之为议题的提出，针对着没有未来，即“末日”。笔者的问题是：资本主义的末日是否人类的末日？或者，如何避免资本主义的末日成为人类的末日？未来议题同时是关于革命及共产主义的再思考。 The focus of this paper is on “the future” as a subject of concern, and the parameters within which it is broached in the context of the 21st century. For the writer, the question of “the future” is not really a temporal one, neither is it another name for utopia. Rather, it is moved by apprehensions of the disappearance of time altogether, that is, the looming of doom. My question is: is the end of capitalism the end of humanity? Or rather, how to avoid the fall of capitalism to bring about the fall of humanity, a question inevitably leading to the rethinking of revolutions and communism

Després de la Postguerra Freda

En el número 62 de la revista L'Espill trobaràs un dossier monogràfic sobre "La Xina del present, el món del futur", amb contribucions de David Martínez-Robles, Carles Prado-Fonts, Javier Borràs Arumí, Carles Brasó Broggi, Irene Masdeu Torruella, Xavier Ortells Nicolau, Jesús Sayols Lara, Manel Ollé i Dai Jinhua. A més, articles de Ramon Villares, Josep Alapont, Lluís Meseguer, Maria Lacueva i Josep J. Conill, així com La mirada de Carlos Bunga

microRNA-29a functions as a tumor suppressor in nasopharyngeal carcinoma 5-8F cells through targeting VEGF

Objective(s): microRNA-29 (miR-29) family miRNAs have been mentioned as tumor suppressive genes in several human cancers. The purpose of this study was to investigate the function of miR-29a in nasopharyngeal carcinoma (NPC) cells. Materials and Methods: Human NPC cell line 5-8F was transfected with mimic, inhibitor or scrambled controls specific for miR-29a. Subsequently, cell viability, migration, apoptosis and expression changes of VEGF were assessed by trypan blue staining, MTT assay, transwell assay, flow cytometry, Western blot and RT-qPCR. TargetScan online database was used to predict the targets of miR-29a, and luciferase reporter assay was carried out for testing the targeting relationship between VEGF and miR-29a. Western blot analysis was performed to determine the expression changes of core proteins in PI3K/AKT and JAK/STAT pathways. Results: Overexpression of miR-29a suppressed 5-8F cells viability and relative migration, but increased apoptotic cell rate. Consistently, Bcl-2 was downregulated, Bax was upregulated, and caspase-3 and -9 were cleaved by miR-29a overexpression. VEGF was a target gene of miR-29a. Besides, VEGF silence exerted similar effects like miR-29a, as the viability and migration were repressed and apoptosis was induced. Finally, we found that PI3K/AKT and JAK/STAT pathways were deactivated by miR-29a or VEGF silence. Conclusion: These findings highlighted the tumor suppressive effects of miR-29a on NPC cells, as its overexpression inhibited 5-8F cells viability, migration, and induced apoptosis. miR-29a exerted tumor suppressive functions might be via targeting VEGF and deactivating PI3K/AKT and JAK/STAT pathways

1-[(2,3,4,5,6-Penta­fluoro­phen­yl)ethyn­yl]ferrocene

The mol­ecular structure of the title compound, [Fe(C5H5)(C13H4F5)], consists of a ferrocenyl group and a 2,3,4,5,6-penta­fluoro­benzene group linked through an ethyne spacer. The crystal packing is dominated by inter­molecular C—H⋯F hydrogen bonds, C—F⋯π inter­actions between the penta­fluoro­benzene groups [F⋯centroid distances = 3.882 (2) and 3.884 (2) Å] and π–π inter­actions between the penta­fluoro­benzene and cyclo­penta­dienyl rings [centroid–centroid distance = 3.741 (1) Å]