FLAG3D: A 3D Fitness Activity Dataset with Language Instruction

With the continuously thriving popularity around the world, fitness activity analytic has become an emerging research topic in computer vision. While a variety of new tasks and algorithms have been proposed recently, there are growing hunger for data resources involved in high-quality data, fine-grained labels, and diverse environments. In this paper, we present FLAG3D, a large-scale 3D fitness activity dataset with language instruction containing 180K sequences of 60 categories. FLAG3D features the following three aspects: 1) accurate and dense 3D human pose captured from advanced MoCap system to handle the complex activity and large movement, 2) detailed and professional language instruction to describe how to perform a specific activity, 3) versatile video resources from a high-tech MoCap system, rendering software, and cost-effective smartphones in natural environments. Extensive experiments and in-depth analysis show that FLAG3D contributes great research value for various challenges, such as cross-domain human action recognition, dynamic human mesh recovery, and language-guided human action generation. Our dataset and source code will be publicly available at https://andytang15.github.io/FLAG3D

TextBox 2.0: A Text Generation Library with Pre-trained Language Models

To facilitate research on text generation, this paper presents a comprehensive and unified library, TextBox 2.0, focusing on the use of pre-trained language models (PLMs). To be comprehensive, our library covers $13$ common text generation tasks and their corresponding $83$ datasets and further incorporates $45$ PLMs covering general, translation, Chinese, dialogue, controllable, distilled, prompting, and lightweight PLMs. We also implement $4$ efficient training strategies and provide $4$ generation objectives for pre-training new PLMs from scratch. To be unified, we design the interfaces to support the entire research pipeline (from data loading to training and evaluation), ensuring that each step can be fulfilled in a unified way. Despite the rich functionality, it is easy to use our library, either through the friendly Python API or command line. To validate the effectiveness of our library, we conduct extensive experiments and exemplify four types of research scenarios. The project is released at the link: https://github.com/RUCAIBox/TextBox.Comment: Accepted by EMNLP 202

MicroRNA-322 inhibits inflammatory cytokine expression and promotes cell proliferation in LPS-stimulated murine macrophages by targeting NF-κB1 (p50)

Correspondence : Hanchuan Dai ([email protected]) Inflammation is the body's normal self-protection mechanism to eliminate pathogens and resist pathogen invasion. The excessive inflammatory response may lead to inflammatory lesions. The mechanisms accounting for inflammation remain hazy. miRNAs have been proposed to have crucial effects on inflammation. In the present study, we reported that lipopolysaccharide (LPS)-stimulation increased the expression levels of inflammatory cytokines and the cell-cycle progression was suppressed in RAW264.7 cells. Meanwhile, the expression of miR-322 was significantly down-regulated after LPS treatment. Bioinformatics predictions revealed a potential binding site of miR-322 in 3 -UTR of NF-κB1 (p50) and it was further confirmed by luciferase assay. Moreover, both the mRNA and protein levels of NF-κB1 (p50) were down-regulated by miR-322 in RAW264.7 cells. Subsequently, we demonstrated that miR-322 mimics decrease in the expression levels of inflammatory cytokines and cell-cycle repression can be rescued following LPS treatment in RAW264.7 cells. The anti-inflammatory cytokines expression including IL-4 and IL-10 were significantly up-regulated. Furthermore, miR-322 could also promote RAW264.7 cells proliferation. These results demonstrate that miR-322 is a negative regulator of inflammatory response by targeting NF-κB1 (p50)

ACCEPTED MANUSCRIPT MicroRNA-322 inhibits inflammatory cytokine expression and promotes cell proliferation in LPS-stimulated murine macrophages by targeting NF-κB1 (P50) BIOSCIENCE REPORTS MicroRNA-322 inhibits inflammatory cytokine expression and promote

Inflammation is the body's normal self-protection mechanism to eliminate pathogens and resist pathogen invasion. The excessive inflammatory response may lead to inflammatory lesions. The mechanisms accounting for inflammation remain hazy. MicroRNAs (miRNAs) have been proposed to have crucial effects on inflammation. In the current study, we reported that lipopolysaccharide (LPS) stimulation increases the expression levels of inflammatory cytokines and the cell cycle progression was suppressed in RAW264.7 cells. Meanwhile, the expression of miR-322 was significantly downregulated after LPS treated. Bioinformatics predictions revealed a potential binding site of miR-322 in 3′-untranslated region (3′-UTR) of and it was further confirmed by luciferase assay. Moreover, both the mRNA and protein levels of NF-κB1 (P50) were downregulated by miR-322 in RAW264.7. Subsequently, we demonstrate that miR-322 mimics decrease the expression levels of inflammatory cytokines and cell cycle repression can be rescued following LPS treated in RAW264.7 cells. The anti-inflammatory cytokines expression including IL-4 and IL-10 were significant up-regulation. Furthermore, miR-322 also could promote RAW264.7 cells proliferation. These results demonstrate that miR-322 is a negative regulator of inflammatory response by targeting NF-κB1 (P50). Abstract Inflammation is the body's normal self-protection mechanism to eliminate pathogens and resist pathogen invasion. The excessive inflammatory response may lead to inflammatory lesions. The mechanisms accounting for inflammation remain hazy. MicroRNAs (miRNAs) have been proposed to have crucial effects on inflammation. In the current study, we reported that lipopolysaccharide (LPS) stimulation increases the expression levels of inflammatory cytokines and the cell cycle progression was suppressed in RAW264.7 cells. Meanwhile, the expression of miR-322 was significantly downregulated after LPS treated. Bioinformatics predictions revealed a potential binding site of miR-322 in 3′-untranslated region (3′-UTR) of NF-κB1 (P50) and it was further confirmed by luciferase assay. Moreover, both the mRNA and protein levels of NF-κB1 (P50) were downregulated by miR-322 in RAW264.7. Subsequently, we demonstrate that miR-322 mimics decrease the expression levels of inflammatory cytokines and cell cycle repression can be rescued following LPS treated in RAW264.7 cells. The anti-inflammatory cytokines expression including IL-4 and IL-10 were significant up-regulation. Furthermore, miR-322 also could promote RAW264.7 cells proliferation. These results demonstrate that miR-322 is a negative regulator of inflammatory response by targeting NF-κB1 (P50)

Experimental Study on Oil Drop Discharge Behavior during Dynamic Imbibition in Tight Oil Sandstone with Aid of Surfactant

The pore and throat structure of tight oil reservoir cores is complex, and the resistance of oil drop to discharge from the core is very high during dynamic imbibition. Surfactant has good ability in interfacial tension reduction and wettability reversal. It can reduce oil drop discharge resistance and enhance oil recovery effectively during dynamic imbibition in tight reservoirs. Here, we first analyzed the pore throat structure and mineral composition of tight core, and then the oil drop visualization instrument was used to study the discharge behavior of oil drop during dynamic imbibition. The oil drop discharge form was analyzed, and the influence of various factors on the oil drop discharge behavior was explored, and then the dynamic imbibition performance of surfactant in tight cores was obtained. The core throat diameter was mainly distributed in 0.07–1.1 μm, and the hydrophilic mineral content in core reached 50.8%. In the case of fluid flow in fracture, the oil drop discharge from near fracture matrix was faster, and its growth rate in height and width was faster than that without external fluid flow. Within a certain range, with the increase of IFT, the rate of core imbibition increased gradually. When the IFT increased from 0.32 mN/m to 0.59 mN/m, the oil drop rapture time decreased by 66.3%. The growth rate of oil drop discharged from the top and side of the core was faster than that from the bottom surface. Furthermore, it was easier to discharge. With the core thickness reduced by half, the rapture time of oil drop was reduced by 74.7%. For tight reservoirs, hydraulic fracturing can create more fracture surfaces and reduce the size of matrix blocks, which contributes to reduce the oil drop discharge resistance during imbibition and improve the oil recovery. This study provides a basis for surfactant to improve dynamic imbibition and oil production performance of tight sandstone oil reservoir

Experimental Study on Oil Drop Discharge Behavior during Dynamic Imbibition in Tight Oil Sandstone with Aid of Surfactant

The pore and throat structure of tight oil reservoir cores is complex, and the resistance of oil drop to discharge from the core is very high during dynamic imbibition. Surfactant has good ability in interfacial tension reduction and wettability reversal. It can reduce oil drop discharge resistance and enhance oil recovery effectively during dynamic imbibition in tight reservoirs. Here, we first analyzed the pore throat structure and mineral composition of tight core, and then the oil drop visualization instrument was used to study the discharge behavior of oil drop during dynamic imbibition. The oil drop discharge form was analyzed, and the influence of various factors on the oil drop discharge behavior was explored, and then the dynamic imbibition performance of surfactant in tight cores was obtained. The core throat diameter was mainly distributed in 0.07–1.1 μm, and the hydrophilic mineral content in core reached 50.8%. In the case of fluid flow in fracture, the oil drop discharge from near fracture matrix was faster, and its growth rate in height and width was faster than that without external fluid flow. Within a certain range, with the increase of IFT, the rate of core imbibition increased gradually. When the IFT increased from 0.32 mN/m to 0.59 mN/m, the oil drop rapture time decreased by 66.3%. The growth rate of oil drop discharged from the top and side of the core was faster than that from the bottom surface. Furthermore, it was easier to discharge. With the core thickness reduced by half, the rapture time of oil drop was reduced by 74.7%. For tight reservoirs, hydraulic fracturing can create more fracture surfaces and reduce the size of matrix blocks, which contributes to reduce the oil drop discharge resistance during imbibition and improve the oil recovery. This study provides a basis for surfactant to improve dynamic imbibition and oil production performance of tight sandstone oil reservoir