Research on Modular Business Processes

Business processes of traditional functional organizations are hard to respond to the rapidly changing market in the information era, so modular organizations are given attentions. In this paper, business processes in modular organizations based on the commitments between competence modules are analyzed and process reengineering of the Haier Company is used to illustrate the characteristics of modular organization processes

Extending synthetic control method for multiple treated units: an application to environmental intervention

Taking the environmental interventions on air quality at G20 Hangzhou Summit as a natural experiment, this paper innovatively establishes an extended synthetic control method with multiple units to evaluate the dynamic treatment effects on air quality improvement at the Summit. The method constructs datadriven weights according to the fluctuation of urban air quality to obtain a more robust and stable estimation with smaller root mean squared prediction error (RMSPE). By minimising RMSPE for pre-intervention model fitting, the study takes nine cities under policy intervention in Zhejiang as treatment cities, and 45 key cities without policy intervention as control cities during 201501–201706 as the final improved experimental scheme. The policy effect of environmental regulations on the average monthly air quality composite index of treated cities in Zhejiang is -0.84 during 201607–201702; while no significant treatment effect is observed since 201702. The results indicate that the environmental policy for the G20 Hangzhou Summit lasted a relatively short period, and it had a significant short-term improvement effect while losing its long-term improving effect on air quality in treated cities. The identification validates the extended synthetic control method with multiple units could also be applied to the policy effect evaluation in other areas

Fused Text Segmentation Networks for Multi-oriented Scene Text Detection

In this paper, we introduce a novel end-end framework for multi-oriented scene text detection from an instance-aware semantic segmentation perspective. We present Fused Text Segmentation Networks, which combine multi-level features during the feature extracting as text instance may rely on finer feature expression compared to general objects. It detects and segments the text instance jointly and simultaneously, leveraging merits from both semantic segmentation task and region proposal based object detection task. Not involving any extra pipelines, our approach surpasses the current state of the art on multi-oriented scene text detection benchmarks: ICDAR2015 Incidental Scene Text and MSRA-TD500 reaching Hmean 84.1% and 82.0% respectively. Morever, we report a baseline on total-text containing curved text which suggests effectiveness of the proposed approach.Comment: Accepted by ICPR201

Pharmacokinetic studies and anticancer activity of curcumin-loaded nanostructured lipid carriers

In order to investigate the potential of nanostructured lipid carriers for efficient and targeted delivery of curcumin, the pharmacokinetic parameters of curcumin-loaded nanostructured lipid carriers (Cur-NLC) were evaluated in rats after a single intraperitoneal dose of Cur-NLC. In addition, the anticancer activity of Cur-NLC against human lung adenocarcinoma A549 cells was verified by a cellular uptake study, and a cytotoxicity and apoptosis assay. Bioavailability of Cur-NLC was better than that of native curcumin (p > 0.01), as seen from the area under the plasma concentration-time curve (AUC), maximum plasma concentration (Cmax), mean residence time (MRT) and total plasma clearance (CLz/F). Cur-NLC has a more obvious lung-targeting property in comparison with native curcumin. Cur-NLC showed higher anticancer activity in vitro against A549 cells than native curcumin (IC50 value of 5.66 vs. 9.81 mg L–1, respectively). Meanwhile, Cur-NLC treated A549 cells showed a higher apoptosis rate compared to that of native curcumin. These results indicate that NLC is a promising system for the delivery of curcumin in the treatment of lung adenocarcinoma

Growth of Human Colorectal Cancer SW1116 Cells Is Inhibited by Cytokine-Induced Killer Cells

Previous reports have suggested that treatment with cytokine-induced killer (CIK) cells may benefit patients with various types of tumor. The aim of this study was to evaluate the antitumor effects of CIK cells against the colorectal cancer line SW1116 in vitro and in vivo. CIK cells were generated routinely from peripheral blood mononuclear cells of healthy human donors, and the number of CD3+CD56+ cells was expanded more than 1300-fold after 14-day culture. At an effector : target cell ratio of 50 : 1, the percentage lysis of SW1116 cells reached 68% in the presence of CIK cells, Experimental mice injected with SW1116 cells subcutaneously were divided randomly into four groups: untreated, 5-fluorouracil (5-FU)-treated, CIK-consecutive treated (injected once/day) and CIK-interval treated (injected once every 5 days). CIK cells were injected abdominally five times in total. Compared with the untreated group, xenograft growth was inhibited greatly by CIK treatment, to nearly the same extent as with 5-FU treatment. We demonstrated that the necrotic area in the tumor xenograft was markedly larger in the CIK-treated groups than in the other groups. These findings suggest that CIK-based immunotherapy may represent an effective choice for patients with colorectal cancer

Curcumin-loaded nanostructured lipid carrier induced apoptosis in human HepG2 cells through activation of DR5/caspases-mediated extrinsic apoptosis pathway

Curcumin is a lipophilic anti-cancer compound extracted from turmeric. Our previous study demonstrated that the curcumin-loaded nanostructured lipid carrier (Cur-NLC) exhibits superior anti-cancer activity in inhibiting proliferation as well as inducing apoptosis of human HepG2 cells compared to native curcumin. This study aims to unveil the mechanisms underlying the pro-apoptotic effect of Cur-NLC on HepG2 cells. Evidence indicates that low expression of death receptors (DRs) on cancer cell membranes leads to attenuated apoptosis signaling. This study showed that Cur-NLC significantly increased total expression of DR5 protein while simultaneously upregulated cell membrane expression of DR5. Cur-NLC significantly increased caspase-8 and caspase-3 activities, accompanied by increased apoptosis. Furthermore, enhanced apoptosis was inhibited in the presence of a pan-caspase inhibitor, Z-VAD-FMK. Therefore, Cur-NLC induced activation of the extrinsic apoptosis pathway via modulating the DR5/caspase-8/-3 mediated apoptosis pathway in HepG2 cells, suggesting that Cur-NLC is a promising therapeutic agent or supplement for the treatment of hepatocellular carcinoma

Satellite-derived surface water pCO(2) and air-sea CO2 fluxes in the northern South China Sea in summer

An empirical approach is presented for the estimation of the partial pressure of carbon dioxide (pCO(2)) and air-sea CO2 fluxes in the northern South China Sea in summer using satellite-derived sea surface temperatures (SSTs), chlorophyll-a (Chl a) concentrations, and wind fields. Two algorithms were tested. The first used an SST-dependent equation, and the other involved the introduction of Chl a. Regression equations were developed for summer based on in situ data obtained in July, 2004. Using the monthly average SST and Chl a fields derived from the advanced very high resolution radiometer (AVHRR) and the SeaWiFS (sea-viewing wide field of view sensor), respectively, the monthly pCO(2) fields were computed. The derived pCO(2) was compared with the shipboard pCO(2) observations conducted in July, 2000. This resulted in a root-mean-square error of 4.6 mu atm, suggesting that the satellite-derived pCO(2) was in general agreement with the in situ observations. The air-sea CO2 flux was further computed with the aid of the monthly mean QuikSCAT wind speed. We contend that more shipboard data are necessary for refining the empirical algorithms and reducing the uncertainty in the results. (C) 2009 National Natural Science Foundation of China and Chinese Academy of Sciences. Published by Elsevier Limited and Science in China Press. All rights reserved.National Basic Research Program of China [2009CB421200, 2009CB421201]; National Natural Science Foundation of China [40521003, 90711005]; High-Tech R&D Program of China [2006AA09A302, 2007AA09Z127