105 research outputs found
Interfacial thermal transport with strong system-bath coupling: A phonon delocalization effect
We study the effect of system-bath coupling strength on quantum thermal
transport through the interface of two weakly coupled anharmonic molecular
chains using quantum self-consistent phonon approach. The heat current shows a
resonant to bi-resonant transition due to the variations in the interfacial
coupling and temperature, which is attributed to the delocalization of phonon
modes. Delocalization occurs only in the strong system-bath coupling regime and
we utilize it to model a thermal rectifier whose ratio can be non-monotonically
tuned not only with the intrinsic system parameters but also with the external
temperature.Comment: 7 pages, 7 figure
Origin of negative differential thermal resistance in a chain of two weakly coupled nonlinear lattices
Negative differential resistance in electronic conduction has been
extensively studied, but it is not the case for its thermal counterpart,
namely, negative differential thermal resistance (NDTR). We present a classical
Landauer formula in which the nonlinearity is incorporated by the
self-consistent phonon theory in order to study the heat flux across a chain
consisting of two weakly coupled lattices. Two typical nonlinear models of hard
and soft on-site potentials are discussed, respectively. It is shown that the
nonlinearity has strong impacts on the occurring of NDTR. As a result, a
transition from the absence to the presence of NDTR is observed. The origin of
NDTR consists in the competition between the temperature difference, which acts
as an external field, and the temperature-dependent thermal boundary
conductance. Finally, the onset of the transition is clearly illustrated for
this model. Our analytical calculation agrees reasonably well with numerical
simulations.Comment: 6 pages, 8 figue
Determination of Kepone and Its Metabolite in Water and Soil by High-Performance Liquid Chromatography–Mass Spectrometry
A Cellular Pathway Involved in Clara Cell to Alveolar Type II Cell Differentiation after Severe Lung Injury
Regeneration of alveolar epithelia following severe pulmonary damage is critical for lung function. We and others have previously shown that Scgb1a1-expressing cells, most likely Clara cells, can give rise to newly generated alveolar type 2 cells (AT2s) in response to severe lung damage induced by either influenza virus infection or bleomycin treatment. In this study, we have investigated cellular pathway underlying the Clara cell to AT2 differentiation. We show that the initial intermediates are bronchiolar epithelial cells that exhibit Clara cell morphology and express Clara cell marker, Scgb1a1, as well as the AT2 cell marker, pro-surfactant protein C (pro-SPC). These cells, referred to as pro-SPC[superscript +] bronchiolar epithelial cells (or SBECs), gradually lose Scgb1a1 expression and give rise to pro-SPC[superscript +] cells in the ring structures in the damaged parenchyma, which appear to differentiate into AT2s via a process sharing some features with that observed during alveolar epithelial development in the embryonic lung. These findings suggest that SBECs are intermediates of Clara cell to AT2 differentiation during the repair of alveolar epithelia following severe pulmonary injury.Singapore-MIT Alliance for Research and Technology Center. Infectious Disease Research Grou
A photo-triggered and photo-calibrated nitric oxide donor: rational design, spectral characterizations, and biological applications
Nitric oxide (NO) donors are valuable tools to probe the profound implications of NO in health and disease. The elusive nature of NO bio-relevance has largely limited the use of spontaneous NO donors and promoted the development of next generation NO donors, whose NO release is not only stimulated by a trigger, but also readily monitored via a judiciously built-in self-calibration mechanism. Light is without a doubt the most sensitive, versatile and biocompatible method of choice for both triggering and monitoring, for applications in complex biological matrices. Herein, we designed and synthesized an N-nitroso rhodamine derivative (NOD560) as a photo-triggered and photo-calibrated NO donor to address this need. NOD560 is essentially non-fluorescent. Upon irradiation by green light (532nm), it efficiently release NO and a rhodamine dye, the dramatic fluorescence turn-on from which could be harnessed to conveniently monitor the localization, flux, and dose of NO release. The potentials of NOD560 for in vitro biological applications were also exemplified in in vitro biological models, i.e. mesenchymal stem cell (MSC) migration suppression. NOD560 is expected to complement the existing NO donors and find widespread applications in chemical biological studies
- …