Orthovoltage radiotherapy for nonmelanoma skin cancer (NMSC): Comparison between 2 different schedules

Background Radiotherapy is an established treatment for some types of patients with nonmelanoma skin cancer. A hypofractionated schedule has been proposed as a valuable option for elderly disabled patients to minimize the number of hospital visits. Objective We sought to compare a weekly hypofractionated orthovoltage radiotherapy regimen with a standard daily one for the treatment of nonmelanoma skin cancer. Methods A retrospective cohort study was performed on 436 tumors. Overall survival, disease-free survival, and cosmetic outcome were measured. Life-table analysis, Kaplan-Meier survival analysis, and multivariate Cox regression model were performed. Results The hypofractionated regimen was not associated with increased recurrence rates and mortality, or with a poorer cosmetic outcome, when compared with the daily schedule. Limitations Absence of complete information about acute treatment toxicity and a shorter follow-up time for patients receiving the weekly schedule are limitations of this study. Conclusions A weekly hypofractionated regimen of orthovoltage radiotherapy seems to be the most appropriate approach in elderly disabled patients with nonmelanoma skin cancers

Dermoscopy in the diagnosis and management of basal cell carcinoma

10The dermoscopic findings of basal cell carcinoma (BCC) were first described more than a decade ago and the list of BCC-related criteria has been several times updated and enriched. Today, the dermatoscope is considered the key tool for the diagnosis of BCC, since it allows its early detection and enables its discrimination from other pigmented and nonpigmented skin tumors. The dermoscopic pattern of BCC results from several combinations of well-known BCC criteria, depending on several factors, including histopathologic subtype, location, gender, age and pigmentary trait. In addition, recent evidence highlighted that dermoscopy is also useful in the management of BCC, since it provides information on the tumor subtype, the presence of pigmentation or ulceration and the response to nonablative treatments.reservednonemixedLallas, Aimilios*; Apalla, Zoe; Ioannides, Dimitrios; Argenziano, Giuseppe; Castagnetti, Fabio; Moscarella, Elvira; Longo, Caterina; Palmieri, Tamara; Ramundo, Dafne; Zalaudek, IrisLallas, Aimilios; Apalla, Zoe; Ioannides, Dimitrios; Argenziano, Giuseppe; Castagnetti, Fabio; Moscarella, Elvira; Longo, Caterina; Palmieri, Tamara; Ramundo, Dafne; Zalaudek, Iri

RISULTATI DELLA RADIOTERAPIA PANENCEFALICA (WBRT) NELLE METASTASI CEREBRALI DA CARCINOMA DELLA MAMMELLA: STUDIO RETROSPETTIVO SUL RUOLO PROGNOSTICO DEI FATTORI BIOLOGICI

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