33 research outputs found
Antagonistic effects of Satureja hortensis essential oil against AFB, on human lymphocytes in vitro
Satureja hortensis L. (Lamiaceae) ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΡΡΡ ΠΊΠ°ΠΊ Π½Π°ΡΠΎΠ΄Π½ΠΎΠ΅ ΡΡΠ΅Π΄ΡΡΠ²ΠΎ Π΄Π»Ρ Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΠ°Π·Π½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, ΡΠ°ΠΊΠΈΡ
ΠΊΠ°ΠΊ ΡΠΏΠ°Π·ΠΌΡ, ΠΌΡΡΠ΅ΡΠ½ΡΠ΅ Π±ΠΎΠ»ΠΈ, ΡΠΎΡΠ½ΠΎΡΠ°, Π½Π°ΡΡΡΠ΅Π½ΠΈΡ ΠΏΠΈΡΠ΅Π²Π°ΡΠ΅Π½ΠΈΡ, Π΄ΠΈΠ°ΡΠ΅Ρ ΠΈ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΡΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ. Π Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΠ΅ Π½Π° ΠΏΡΠΈΠΌΠ΅ΡΠ΅ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° in vitro ΠΈΠ·ΡΡΠ°Π»ΠΈ Π°Π½ΡΠ°Π³ΠΎΠ½ΠΈΡΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΡΡΠΈΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠ»Π° S. hortensis (SHE) Π½Π° Π°ΡΠ»Π°ΡΠΎΠΊΡΠΈΠ½Ρ Bβ (AFBβ). ΠΠ½Π°Π»ΠΈΠ· ΡΡΠΈΡΠ½ΡΡ
ΠΌΠ°ΡΠ΅Π» ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΡΡ Ρ ΠΏΠΎΠΌΠΎΡΡΡ Π³Π°Π·ΠΎΠ²ΠΎΠΉ Ρ
ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠΈΠΈ β ΠΌΠ°ΡΡ-ΡΠΏΠ΅ΠΊΡΡΠΎΠΌΠ΅ΡΡΠΈΠΈ (GC-MS). ΠΠ½ΡΠΈΠ³Π΅Π½ΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΡΠ΅ΠΊΡ SHE Π±ΡΠ» ΠΎΡΠ΅Π½Π΅Π½ Π½Π° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΎΠ±ΠΌΠ΅Π½Π° ΡΠ΅ΡΡΡΠΈΠ½ΡΠΊΠΈΡ
Ρ
ΡΠΎΠΌΠ°ΡΠΈΠ΄ (SCE) ΠΈ ΠΌΠΈΠΊΡΠΎΡΠ΄Π΅ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΡΡΠ° ΠΏΡΠΎΡΠΈΠ² AFBβ. ΠΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, Π΄Π»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°ΡΠΈΠ²Π½ΡΡ
ΡΡΡΠ΅ΠΊΡΠΎΠ² SHE ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ ΡΡΠΎΠ²Π΅Π½Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠ΅ΠΉ ΠΌΠ°Π»ΠΎΠ½ΠΎΠ²ΡΡ
Π΄ΠΈΠ°Π»ΡΠ΄Π΅Π³ΠΈΠ΄ΠΎΠ² (MDA), ΡΡΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π΄ΠΈΡΠΌΡΡΠ°Π·Ρ (SOD) ΠΈ Π³Π»ΡΡΠ°ΡΠΈΠΎΠ½ΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π°Π·Ρ (GPx). ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ AFBβ (5 Β΅M) ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π΅Ρ ΡΠ°ΡΡΠΎΡΡ SCE, MN ΠΈ ΡΡΠΎΠ²Π΅Π½Ρ MDA. AFBβ Π² ΡΠΎΠΉ ΠΆΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΡΠ½ΠΈΠΆΠ°Π΅Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ SOD ΠΈ GPx. ΠΠ΄Π½Π°ΠΊΠΎ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ SHE Ρ AFBβ ΡΠ½ΠΈΠΆΠ°Π»ΠΈ ΡΠ°ΡΡΠΎΡΡ SCE, MN ΠΈ ΡΡΠΎΠ²Π΅Π½Ρ MDA, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π»ΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ SOD ΠΈ GPx. ΠΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ SHE 1.0, 1.5, 2.0 Β΅L Π±ΡΠ»ΠΈ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌΠΈ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠ°Π±ΠΎΡΡ ΡΠ΅ΡΠΊΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ, ΡΡΠΎ SHE ΠΈΠΌΠ΅Π΅Ρ ΡΠΈΠ»ΡΠ½ΡΠΉ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°ΡΠΈΠ²Π½ΡΠΉ ΠΈ Π°Π½ΡΠΈ-Π³Π΅Π½ΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΡΠ΅ΠΊΡ. Π’Π°ΠΊΠ°Ρ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅ΡΡΡ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΠΎΡΡΠ°Π²ΠΎΠΌ SHE.Satureja hortensis L. (Lamiaceae) has been used as a folk remedy to treat various such as cramps, muscle pains, nausea, indigestion, diarrhea, and infectious diseases. In this study, the antagonistic effects of essential oil of S. hortensis (SHE) were studied against aflatoxin Bβ (AFBβ) in human lymphocytes in vitro. The analysis of the essential oil was performed by using Gas chromatography-mass spectrometry (GC-MS). Anti-genotoxic effects of the SHEs was evaluated using sister chromatid exchange (SCE), micronuclei (MN) tests against AFBβ. Also level of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities used to determine the anti-oxidative effects of the SHEs. This result showed AFBβ (5 ΞΌM) increased the frequencies of SCE, MN and the level of MDA. AFBβ at the same concentration decreased the activities of SOD and GPx. However, different concentrations of SHE with AFBβ decreased the frequency of SCE and MN and level of MDA and also increased the activities of SOD and GPx significantly. Especially, the 1.0, 1.5, 2.0 ΞΌL dose of SHE are more effective than other doses. The results of this experiment have clearly shown that SHE has strong antioxidative and antigenotoxic effects, these biological activities of SHEs can be due to its component