5 research outputs found
Triaxial Electrospun Nanofiber Membranes for Controlled Dual Release of Functional Molecules
A novel dual drug delivery system
is presented using triaxial structured nanofibers, which provides
different release profiles for model drugs separately loaded in either
the sheath or the core of the fiber. Homogenous, coaxial and triaxial
fibers containing a combination of materials (PCL, polycaprolactone;
PVP, polyvinylpyrrolidone) were fabricated. The drug release profiles
were simulated using two color dyes (KAB, keyacid blue; KAU, keyacid
uranine), whose release in physiological solution was measured using
optical absorption as a function of time. To reach the level of 80%
release of encapsulated dye from core, triaxial fibers with a PCL
intermediate layer exhibited a ∼24Ă— slower release than
that from coaxial fibers. At the same time, the hygroscopic sheath
layer of the triaxial fibers provided an initial burst release (∼
80% within an hour) of a second dye as high as that from conventional
single and coaxial fibers. The triaxial fiber membrane provides both
a quick release from the outer sheath layer for short-term treatment
and a sustained release from the fiber core for long-term treatment.
The intermediate layer between inner core and outer sheath acts as
a barrier to prevent leaching from the core, which can be especially
important when the membranes are used in wet application. The formation
of tri/multiaxially electrospun nanofibrous membranes will be greatly
beneficial for biomedical applications by enabling different release
profiles of two different drugs from a membrane
Selective pH-Responsive Core–Sheath Nanofiber Membranes for Chem/Bio/Med Applications: Targeted Delivery of Functional Molecules
Core–sheath
fibers using different Eudragit materials were successfully produced,
and their controlled multi-pH responses have been demonstrated. Core–sheath
fibers made of Eudragit L 100 (EL100) core and Eudragit S 100 (ES100)
sheath provide protection and/or controlled release of core material
at pH 6 by adjusting the sheath thickness (controlled by the flow
rate of source polymer solution). The thickest sheath (∼250
nm) provides the least core release ∼1.25%/h, while the thinnest
sheath (∼140 nm) provides much quicker release ∼16.75%/h.
Furthermore, switching core and sheath material dramatically altered
the pH response. Core–sheath fibers made of ES100 core and
EL100 sheath can provide a consistent core release rate, while the
sheath release rate becomes higher as the sheath layer becomes thinner.
For example, the thinnest sheath (∼120 nm) provides a core
and sheath release ratio of 1:2.5, while the thickest sheath (∼200
nm) shows only a ratio of 1:1.7. All core–sheath Eudragit fibers
show no noticeable release at pH 5, while they are completely dissolved
at pH 7. Extremely high surface area in the porous network of the
fiber membranes provides much faster (>30 times) response to external
pH changes as compared to that of equivalent cast films
Absorption of Ethylene on Membranes Containing Potassium Permanganate Loaded into Alumina-Nanoparticle-Incorporated Alumina/Carbon Nanofibers
Ethylene is a natural
aging hormone in plants, and controlling
its concentration has long been a subject of research aimed at reducing
wastage during packaging, transport, and storage. We report on packaging
membranes, produced by electrospinning, that act as efficient carriers
for potassium permanganate (PPM), a widely used ethylene oxidant.
PPM salt loaded on membranes composed of alumina nanofibers incorporating
alumina nanoparticles outperform other absorber systems and oxidize
up to 73% of ethylene within 25 min. Membrane absorption of ethylene
generated by avocados was totally quenched in 21 h, and a nearly zero
ethylene concentration was observed for more than 5 days. By comparison,
the control experiments exhibited a concentration of 53% of the initial
value after 21 h and 31% on day 5. A high surface area of the alumina
nanofiber membranes provides high capacity for ethylene absorption
over a long period of time. In combination with other properties,
such as planar form, flexibility, ease of handling, and lightweight,
these membranes are a highly desirable component of packaging materials
engineered to enhance product lifetime
Stimuli-Responsive Self-Immolative Polymer Nanofiber Membranes Formed by Coaxial Electrospinning
The first self-immolative
polymer (SIP) nanofiber membrane is demonstrated
in this report, in which the immolation can be triggered by external
stimulus. Electrospun SIP/polyacrylonitrile (PAN) fibers provide depolymerization
that is ∼25 times quicker and more responsive (i.e., immolation)
than that of a cast film in the triggering condition. Depolymerization
of SIP in the SIP/PAN blended fiber membrane results in the transition
of the surface properties from hydrophobic (∼110°) to
hygroscopic (∼0°). Triggered release of encapsulated functional
molecules was demonstrated using coaxially electrospun fiber membrane
made of a SIP/PAN blend sheath and polyvinylpyrrolidone/dye core.
Coaxial fibers with the SIP/PAN sheath provide minimal release of
the encapsulated material in nontriggering solution, while it releases
the encapsulated material instantly when the triggering condition
is met. Its versatility has been strengthened compared to that of
non-SIP coaxial fibers that provide no triggering reaction by external
stimulus
Electrospun Carbon Nanofiber Modified Electrodes for Stripping Voltammetry
Electrospun
polyacrylonitrile (PAN) based carbon nanofibers (CNFs)
have attracted intense attention due to their easy processing, high
carbon yield, and robust mechanical properties. In this work, a CNF
modified glassy carbon (GC) electrode that was coated with Nafion
polymer was evaluated as a new electrode material for the simultaneous
determination of trace levels of heavy metal ions by anodic stripping
voltammetry (ASV). Pb<sup>2+</sup> and Cd<sup>2+</sup> were used as
a representative system for this initial study. Well-defined stripping
voltammograms were obtained when Pb<sup>2+</sup> and Cd<sup>2+</sup> were determined individually and then simultaneously in a mixture.
Compared to a bare GC electrode, the CNF/Nafion modified GC (CNF/Nafion/GC)
electrode improved the sensitivity for lead detection by 8-fold. The
interface properties of the CNF/Nafion/GC were characterized by electrochemical
impedance spectroscopy (EIS), which showed the importance of the ratio
of CNF/Nafion on electrode performance. Under optimized conditions,
the detection limits are 0.9 and 1.5 nM for Pb<sup>2+</sup> and Cd<sup>2+</sup>, respectively