Georges-Louis Leclerc de Buffon, Histoire naturelle, générale et particulière, avec la description du Cabinet du Roi

Figura capitale del xviii secolo francese tanto per la sua acutezza intellettuale quanto per la sua attiva partecipazione alla vita politica e culturale della Francia del suo tempo, Georges-Louis Leclerc de Buffon (Montbard, 1707 - Parigi, 1788) è considerato uno dei più grandi autori del Settecento. Lettore vorace e zelante studioso, Buffon mostra interesse verso varie discipline tra cui la matematica, la fisica e la metafisica. La sua propensione agli studi scientifici viene stimolata, a pa..

Henri de Montfaucon de Villars, Le Comte de Gabalis, ou entretiens sur les sciences secrètes

Le Comte de Gabalis ou entretien sur les sciences secrètes è un trattato pseudo-cabalistico, composto da Henri de Montfaucon de Villars, meglio noto con lo pseudonimo di Abbé de Villars, nel 1670. Il trattato, pur avendo goduto nell’immediato di una buona fortuna editoriale, è stato successivamente considerato poco degno di attenzione critica. In esso Gabalis, personaggio eccentrico che si proclama saggio cabalista, dialoga con un aspirante filosofo, il quale mostra uno spiccato scetticismo n..

Estudios de Historia de España, 1990, vol. 3 (número completo)

Contenido: Formas de la caridad en la España visigoda / Raquel Homet – Los desplazamientos de la corte castellana. Notas para su estudio / María Estela González de Fauve ; Norah B. Ramos ; Patricia de Forteza – Carácter socioeconómico de los juegos y entretenimientos en Castilla. Siglos XIII al XV / María Marcela Mantel – La corrupción en la función pública. Castilla siglo XV / María del Carmen Carlé – Huertas en el siglo XVI. Estructura, características, producción / María Cristina Longinotti – La escuela primaria: vanguardia del pensamiento de Lorenzo Luzuriaga / Teresa María Dabusti – La Gaceta de Madrid. Fuente para el estudio de la reforma agraria / Cayetano Espejo Marín – Documento: Prisión por herir una figura de Cristo (año 1463) – Traducción: Réplicas de los embajadores franceses a las respuestas dadas a sus peticiones por el rey de Castilla (1450), por el “Equipo de traducción y comentario de textos latinos medievales” – Reseñas bibliográfica

Diagnostic work-up for clinical and prognostic assessment of acute leukaemia

Acute leukaemia is a neoplastic disorder of haematopoietic precursors characterized by a rapid clinical course and a relatively high early death rate in spite of recent therapeutic progress. Prompt and reliable diagnostic and prognostic assessment has a favourable impact on patient outcome. Diagnostic suspicion relies on signs and symptoms of bone marrow failure or quali-/quantitative abnormalities of blood cells, which are accurately detected by modern automated counters. Cytomorphological examination of a stained blood and bone marrow film plays a key role in the diagnostic process, with relevant additional information coming from immunophenotyping of blast cells. Cytogenetic and molecular genetic data are the basis of prognostic stratification. In this context, a coordinated intervention of specialized laboratories combining solid expertise in each field involved in the diagnostic work-up is essential; at the same time, the availability of all the required technologies at the same hospital structure would probably lack efficiency due to the low number of tests performed. The organization of laboratory networks, either at regional or national level, especially in the context of clinical trials, may offer a great opportunity for centralization of more sophisticated technologies in reference laboratories, each highly specialized in a particular field of investigation and all interconnected. The challenge for laboratory haematology is the reorganization of clinical and scientific activity according to this model, without loosing educational potential in favour of new generations of medical doctors, haematologists, biologists and laboratory technicians