11,693 research outputs found

    The eigenpairs of a Sylvester-Kac type matrix associated with a simple model for one-dimensional deposition and evaporation

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    A straightforward model for deposition and evaporation on discrete cells of a finite array of any dimension leads to a matrix equation involving a Sylvester-Kac type matrix. The eigenvalues and eigenvectors of the general matrix are determined for an arbitrary number of cells. A variety of models to which this solution may be applied are discussed.Comment: 7 pages, no figure

    Explicit inverses of some tridiagonal matrices

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    We give explicit inverses of tridiagonal 2-Toeplitz and 3-Toeplitz matrices which generalize some well-known results concerning the inverse of a tridiagonal Toeplitz matrix.http://www.sciencedirect.com/science/article/B6V0R-42KDHCJ-2/1/d6207c3bf9c66184210a9296f72fe1e

    Explicit inverses of some tridiagonal matrices

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    We give explicit inverses of tridiagonal 2-Toeplitz and 3-Toeplitz matrices which generalize some well-known results concerning the inverse of a tridiagonal Toeplitz matrix.http://www.sciencedirect.com/science/article/B6V0R-42KDHCJ-2/1/d6207c3bf9c66184210a9296f72fe1e

    Fibonacci numbers, alternating parity sequences and faces of the tridiagonal Birkhoff polytope

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    We determine the number of alternating parity sequences that are subsequences of an increasing m-tuple of integers. For this and other related counting problems we find formulas that are combinations of Fibonacci numbers. These results are applied to determine, among other things, the number of vertices of any face of the polytope of tridiagonal doubly stochastic matrices.http://www.sciencedirect.com/science/article/B6V00-4NF4F6K-H/1/e5d0725d5317b08a025d7df94b2ca64

    The diameter of the acyclic Birkhoff polytope

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    In this work we give an interpretation of vertices and edges of the acyclic Birkhoff polytope, , where T is a tree with n vertices, in terms of graph theory. We generalize a recent result relatively to the diameter of the graph .http://www.sciencedirect.com/science/article/B6V0R-4R70RHM-1/1/4f38cb080e47b5fa8e0d6c36588d41a

    Line and subdivision graphs determined by T4-gain graphs

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    Let T4 = (±1, ±i) be the subgroup of fourth roots of unity inside T, the multiplicative group of complex units. For a T4-gain graph Φ = (Γ,T4, ϕ), we introduce gain functions on its line graph L(Γ) and on its subdivision graph S(Γ). The corresponding gain graphs L(Φ) and S(Φ) are defined up to switching equivalence and generalize the analogous constructions for signed graphs. We discuss some spectral properties of these graphs and in particular we establish the relationship between the Laplacian characteristic polynomial of a gain graph Φ, and the adjacency characteristic polynomials of L(Φ) and S(Φ). A suitably defined incidence matrix for T4-gain graphs plays an important role in this contex

    An intact signal peptide on dengue virus E protein enhances immunogenicity for CD8+ T cells and antibody when expressed from modified vaccinia Ankara

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    Dengue is a global public health concern and this is aggravated by a lack of vaccines or antiviral therapies. Despite the well-known role of CD8(+) T cells in the immunopathogenesis of Dengue virus (DENV), only recent studies have highlighted the importance of this arm of the immune response in protection against the disease. Thus, the majority of DENV vaccine candidates are designed to achieve protective titers of neutralizing antibodies, with less regard for cellular responses. Here, we used a mouse model to investigate CD8(+) T cell and humoral responses to a set of potential DENV vaccines based on recombinant modified vaccinia virus Ankara (rMVA). To enable this study, we identified two CD8(+) T cell epitopes in the DENV-3 E protein in C57BL/6 mice. Using these we found that all the rMVA vaccines elicited DENV-specific CD8(+) T cells that were cytotoxic in vivo and polyfunctional in vitro. Moreover, vaccines expressing the E protein with an intact signal peptide sequence elicited more DENV-specific CD8(+) T cells than those expressing E proteins in the cytoplasm. Significantly, it was these same ER-targeted E protein vaccines that elicited antibody responses. Our results support the further development of rMVA vaccines expressing DENV E proteins and add to the tools available for dengue vaccine development.Parts of this work were supported by the InstitutoNacional de Ciência e Tecnologia de Vacinas–INCTV (National Insti-tute of Science and Technology of Vaccines) and by a FAPEMIGPPM grant (CBB, PPM-00461-11). BRQ was a CAPES/PDSE fellow-ship recipient (8815-11-9). FGF is a CNPq fellowship recipient. DCTis an ARC Future Fellow (FT110100310)
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