Dialysiis practice from the English NHS to the orient

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Mechanisms of Kidney Injury in Lupus Nephritis - the Role of Anti-dsDNA Antibodies

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Clinical and pathological characteristics of patients with glomerular diseases at a university teaching hospital: 5-year prospective review

OBJECTIVE. To examine the prevalence of glomerular disease in Hong Kong. DESIGN. Prospective review. SETTING. University teaching hospital, Hong Kong. PATIENTS. All patients who presented with suspected glomerular disease from 1993 through 1997. MAIN OUTCOME MEASURES. Histopathological diagnosis from biopsy examination and clinical features of presentation. RESULTS. A total of 1629 consecutive percutaneous renal biopsies of native kidneys showed glomerular disease in 1413 cases. The most common clinical indication for renal biopsy was persistent proteinuria (n=735; 52.0%), while the most frequently found glomerular lesion was immunoglobulin A nephropathy (n=338; 23.9%). Minimal-change nephrotic syndrome (n=125; 8.8%) and immunoglobulin M nephropathy (n=11; 0.8%), were the most common glomerular diseases that presented with nephrotic syndrome. The male to female ratio for lupus nephritis was 1:14 (n=290), whereas for minimal-change nephrotic syndrome, the ratio was 1.8:1 (n=125). Immunoglobulin A nephropathy and membranous glomerulonephritis (n=117) affected approximately equal numbers of male and female patients. Familial fibrillary glomerulonephritis, a disease hitherto unknown in Hong Kong, was diagnosed in two siblings. CONCLUSION. Immunoglobulin A nephropathy was the most common glomerular disease in this survey and represents an important cause of end-stage renal failure in the Hong Kong population.published_or_final_versio

Evolution of hepatitis B management in kidney transplantation

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Reversible acute renal failure in a patient with IgA nephropathy

Reversible acute renal failure is a rare complication of IgA nephropathy. We report a patient with IgA nephropathy who developed acute renal failure after an episode of gross haematuria. Renal biopsy revealed extensive acute tubular damage and red blood cell casts. His renal failure recovered spontaneously without specific treatment. The clinical and pathological features of this IgA nephropathy complication are discussed.published_or_final_versio

Risks and benefits of citrate anticoagulation for continuous renal replacment therapy

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Recent advances in the understanding of renal inflammation and fibrosis in lupus nephritis

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Extracorporeal blood purification for sepsis

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Genetic linkage study of family members of a patient with adult polycystic kidney disease

OBJECTIVE. To study the feasibility of making an early diagnosis of adult polycystic kidney disease by using genetic linkage analysis in Hong Kong. DESIGN. Genetic linkage study. SETTING. University teaching hospital, Hong Kong. PARTICIPANTS. Six members of a Chinese family with a history of adult polycystic kidney disease. MAIN OUTCOME MEASURES. The inheritance pattern of adult polycystic kidney disease, as detected by polyacrylamide gel electrophoresis of polymerase chain reaction products using radioactively labelled primers specific to six microsatellite DNA markers that are closely linked to the PKD1 gene on chromosome 16. RESULTS. Four of the six members of the family studied were shown to be positive for disease-linked markers, and the inheritance of adult polycystic kidney disease could be traced in this family with a higher degree of precision (93.7%) using genetic linkage analysis, than could be predicted otherwise. CONCLUSION. The success of genetic linkage analysis in providing an early diagnosis of adult polycystic kidney disease is dependent on having a sufficient number of family members whose disease status has been established by imaging methods to allow the disease-linked marker haplotype to be determined. The establishment of a genetic data bank for families with adult polycystic kidney disease should be considered to maximise the effectiveness of this diagnostic approach.published_or_final_versio

Fibrillary glomerulonephritis: a case report

Fibrillary glomerulonephritis is a recently recognised condition. The usual presentation is heavy proteinuria. The diagnosis is established by demonstration of the characteristic Congo-red negative, randomly arranged microfibrils in the glomeruli by electron microscopy. At present, there is no proven effective treatment for this condition and the prognosis is generally poor. The first case of fibrillary glomerulonephritis diagnosed in Hong Kong is reported here in a 38-year-old woman.published_or_final_versio