Preponderance of Late-spiking Neurons in Rat Lateral Amygdala

Whole-cell recordings from rat lateral amygdala (LA) revealed two populations of principal neurons, that have similar pyramid-like morphologies but differing in firing pattern: late-spiking (LS, 66%) and regular-spiking (RS, 34%). The presence of large numbers of LS neurons arguably supports recent suggestions that the LA should be considered to be a functional extension of perirhinal cortex

Structural Change, Intersectoral Linkages And Hollowing-Out in the Taiwanese Economy, 1976-1994

This paper analyses structural change in the Taiwanese economy over the period 1976-1994 using a series of input-output tables. Unlike other studies of structural change, this analysis investigates the evolving internal complexity of intersectoral interdependencies using Key Sector Analysis which gauges the strength of forward and backward linkages, and the recently developed method of Minimal Flow Analysis, which gauges the degree of connectivity of the system. This analysis indicates that there has been a "hollowing-out" of the Taiwanese economy as the density of intersectoral linkages has declined since the early 1980s, similar to what has been observed of the US and Japanese economies at a much later stage of their development.

Montgomery County, Kentucky Hazardous Materials Commodity Flow Analysis 1

The results of a Commodity Flow Analysis of Hazardous Materials for Interstate 64 (I-64) conducted by Western Kentucky University in partnership with the Montgomery County Local Emergency Planning Committee (LEPC) are presented within this report. This report specifically focuses on the portion of the I-64 corridor located in Montgomery County, Kentucky. Figure 1.1 shows the location of Montgomery County in relationship to the state of Kentucky. The purpose of this report is to present information regarding the patterns of hazardous materials transportation along I-64 as observed from July 14, 2014 through August 1, 2014. In addition, this report also summarizes hazardous materials incidents that have occurred over the previous ten years (January 2004-2013). Finally, the report presents and assesses survey information that was collected from fixed facilities within Montgomery County that ship and receive hazardous materials. The commodity flow analysis was necessary in order to provide the Montgomery County LEPC with information about hazardous materials transport patterns so that they can better prepare for potential incidents and releases of hazardous materials along I-64. The data collected will assist in the emergency planning process by providing valuable information about frequently observed hazardous materials within the duration of the study

Rowan County, Kentucky Hazardous Materials Commodity Flow Analysis

The results of a Commodity Flow Analysis of Hazardous Materials for Interstate 64 (I-64) conducted by Western Kentucky University in partnership with the Rowan County Local Emergency Planning Committee (LEPC) are presented within this report. This report specifically focuses on the portion of the I-64 corridor located in Rowan County, Kentucky. Figure 1.1 shows the location of Rowan County in relationship to the state of Kentucky. The purpose of this report is to present information regarding the patterns of hazardous materials transportation observed along I-64 in Rowan County from June 16, 2014 through July 11, 2014. Finally, the report presents and assesses survey information that was collected from fixed facilities within Rowan County that ship and receive hazardous materials. The commodity flow analysis was necessary in order to provide the Rowan County LEPC with information about hazardous materials transport patterns so that they can better prepare for potential incidents and releases of hazardous materials along I-64. The data collected will assist in the emergency planning process by providing valuable information about frequently observed hazardous materials within the duration of the study

Improvements in prevalence trend fitting and incidence estimation in EPP 2013

OBJECTIVE: Describe modifications to the latest version of the Joint United Nations Programme on AIDS (UNAIDS) Estimation and Projection Package component of Spectrum (EPP 2013) to improve prevalence fitting and incidence trend estimation in national epidemics and global estimates of HIV burden. METHODS: Key changes made under the guidance of the UNAIDS Reference Group on Estimates, Modelling and Projections include: availability of a range of incidence calculation models and guidance for selecting a model; a shift to reporting the Bayesian median instead of the maximum likelihood estimate; procedures for comparison and validation against reported HIV and AIDS data; incorporation of national surveys as an integral part of the fitting and calibration procedure, allowing survey trends to inform the fit; improved antenatal clinic calibration procedures in countries without surveys; adjustment of national antiretroviral therapy reports used in the fitting to include only those aged 15–49 years; better estimates of mortality among people who inject drugs; and enhancements to speed fitting. RESULTS: The revised models in EPP 2013 allow closer fits to observed prevalence trend data and reflect improving understanding of HIV epidemics and associated data. CONCLUSION: Spectrum and EPP continue to adapt to make better use of the existing data sources, incorporate new sources of information in their fitting and validation procedures, and correct for quantifiable biases in inputs as they are identified and understood. These adaptations provide countries with better calibrated estimates of incidence and prevalence, which increase epidemic understanding and provide a solid base for program and policy planning

The third moment of quadratic Dirichlet L-functions

We study the third moment of quadratic Dirichlet L-functions, obtaining an error term of size $O(X^{3/4 + \varepsilon})$.Comment: 27 pages. v2: modified a remark on p.

Atmospheric effects of the emerging mainland Chinese transportation system at and beyond the regional scale

Local surface travel needs in the People's Republic of China (mainland China) have traditionally been met largely by nonpolluting bicycles. A major automobile manufacturing/importing effort has begun in the country over the last decade, and planning documents indicate that the Chinese may strive to acquire more than 100 million vehicles early in the next century. By analogy with large automotive fleets already existing in the western world, both regional and global scale pollution effects are to be expected from the increase. The present work adopts the latest projections of Chinese automobile manufacture and performs some quantitative assessments of the extent of pollution generation. Focus for the investigation is placed upon the oxidant ozone. Emissions of the precursor species nitrogen oxides and volatile organics are constructed based on data for the current automotive sector in the eastern portion of the United States. Ozone production is first estimated from measured values for continental/oceanic scale yields relative to precursor oxidation. The estimates are then corroborated through idealized two dimensional modeling of the photochemistry taking place in springtime air flow off the Asian land mass and toward the Pacific Ocean. The projected fleet sizes could increase coastal and remote oceanic ozone concentrations by tens of parts per billion (ppb) in the lower troposphere. Influences on the tropospheric aerosol system and on the major greenhouse gas carbon dioxide are treated peripherally. Nitrogen oxides created during the vehicular internal combustion process will contribute to nitrate pollution levels measured in the open Pacific. The potential for soot and fugitive dust increases should be considered as the automotive infrastructure develops. Since the emerging Chinese automotive transportation system will represent a substantial addition to the global fleet and all the carbon in gasoline is eventually oxidized completely, a significant rise in global carbon dioxide inputs will ensue as well. Some policy issues are treated preliminary. The assumption is made that alterations to regional oxidant/aerosol systems and to terrestrial climate are conceivable. The likelihood that the Chinese can achieve the latest vehicle fleet goals is discussed, from the points of view of new production, positive pollution feedbacks from a growing automobile industry, and known petroleum reserves. Vehicular fuel and maintenance options lying before the Chinese are outlines and compared. To provide some perspective on the magnitude of the environmental changes associated with an Asian automotive buildup, recent estimates of the effects of future air traffic over the Pacific Rim are described

Combinatorial stress responses: direct coupling of two major stress responses in Escherichia coli

Nitrogen is an essential element for all life, and this is no different for the bacterial cell. Numerous cellular macromolecules contain nitrogen, including proteins, nucleic acids and cell wall components. In Escherichia coli and related bacteria, the nitrogen stress (Ntr) response allows cells to rapidly sense and adapt to nitrogen limitation by scavenging for alternative nitrogen sources through the transcriptional activation of transport systems and catabolic and biosynthetic operons by the global transcriptional regulator NtrC. Nitrogen-starved bacterial cells also synthesize the (p)ppGpp effector molecules of a second global bacterial stress response - the stringent response. Recently, we showed that the transcription of relA, the gene which encodes the major (p)ppGpp synthetase in E. coli, is activated by NtrC during nitrogen starvation. Our results revealed that in E. coli and related bacteria, NtrC functions in combinatorial stress and serves to couple two major stress responses, the Ntr response and stringent response

Madison County, Kentucky Hazardous Materials Commodity Flow Analysis

The results of a commodity flow analysis of hazardous materials for KY Highway 21 (KY-0021) and KY Highway 627 (KY-0627) conducted by Western Kentucky University, in partnership with the Madison County Local Emergency Planning Committee (LEPC), are presented within this report. This report specifically focuses on the portions of these highways located in Madison County, Kentucky. Figure 1.1 shows the location of Madison County in relationship to the state of Kentucky. The purpose of this report is to present information regarding the patterns of hazardous materials transportation along KY-0021 and KY-0627 as observed from August 4, 2014 through August 15, 2014. This report also provides an analysis of incidents involving hazardous materials over the period of 2005 through 2014 in Madison County. Finally, this report summarizes these observations and provides recommendations based on these observations. The commodity flow analysis was necessary in order to provide the Madison County LEPC with information about hazardous materials transport patterns so that they can better prepare for potential incidents and releases of hazardous materials along KY-0021 and KY-0627. Analysis of hazmat incidents in Madison County provided an evaluation of significant hotspots where further risk assessments should be conducted. The data collected will assist in the emergency planning process by providing valuable information about frequently observed hazardous materials within the duration of the study