The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis

This study characterized the ability of a new member of the p35 family, p49, to inhibit a number of mammalian and insect caspases. p49 blocked apoptosis triggered by treatment with Fas ligand (FasL), Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or ultraviolet (UV) radiation but provided negligible protection against apoptosis induced by the chemotherapeutic drug cisplatin. The caspase cleavage site in p49 was determined, and mutation of the 131 residue of this site abolished the ability of p49 to inhibit caspases, implying that p49 inhibits caspases through an analogous suicide-substrate mechanism to p35. Unlike p35, p49 inhibited the upstream insect caspase DRONC

No Laughing Matter: Fraud, the Fabliau and Chaucer’s Franklin’s Tale

In terms of its genre, the Franklin’s Tale is one of Chaucer’s most puzzling texts. It not only presents an Italian novella as a Breton lay, but splices further material from chronicles, saints’ lives and classical and patristic literature into its overall form. This paper aims to deepen the Tale’s complexity by noting the presence of a further, unremarked genre in the text, that of the fabliau. In particular, it pays close attention to the figure of the magician, arguing that this character and his tacitly rationalised sorcery are designed to evoke the rascally clercs escoliers of the French texts, whose trickery often has comparable methods and results. The wider implications of these allusions for interpreting the poem are also considered