Hepatic Abnormalities Associated with Aluminum Loading in Piglets

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141476/1/jpen0293.pd

Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase

Platelet-activating factor (PAF) is one of the most potent lipid mediators involved in inflammatory events. The acetyl group at the sn-2 position of its glycerol backbone is essential for its biological activity. Deacetylation induces the formation of the inactive metabolite lyso-PAF. This deacetylation reaction is catalyzed by PAF-acetylhydrolase (PAF-AH), a calcium independent phospholipase A2 that also degrades a family of PAF-like oxidized phospholipids with short sn-2 residues. Biochemical and enzymological evaluations revealed that at least three types of PAF-AH exist in mammals, namely the intracellular types I and II and a plasma type. Many observations indicate that plasma PAF AH terminates signals by PAF and oxidized PAF-like lipids and thereby regulates inflammatory responses. In this review, we will focus on the potential of PAF-AH as a modulator of diseases of dysregulated inflammation

Technology for mobility in SCI 10 years from now

OBJECTIVES: To identify technological advances and that are likely to have a great impact on the quality of life and participation in individuals with spinal cord injury (SCI). METHODS: In this paper we use the International Classification of Function to frame a discussion on how technology is likely to impact SCI in 10 years. In addition, we discuss the implication of technological advances on future research. RESULTS/CONCLUSION: Although technology advances are exciting, a large challenge for the research community will be how to effectively apply and deploy this technology. Advances occurring in the next 10 years that reduce cost of technology may be more important to the population with SCI than brand new technologies. Social context is everything. As a research community we must advocate for better systems of care. Advocating now for better care will lead to a world in 2020 that is ready to adopt new technologies that are truly transformative.M. Boninger, J. French, J. Abbas, L. Nagy, M. Ferguson-Pell, S.J. Taylor, M. Rodgers, N. Saunders, H. Peckham, R. Marshall and A. Sherwoo

Feedback Set Problems

. This paper is a short survey of feedback set problems. It will be published in Encyclopedia of Optimization, Kluwer Academic Publishers, 2000. 1. INTRODUCTION In recent years feedback set problems have been the subject of growing interest. They have found applications in many fields, including deadlock prevention [89], program verification [78], and Bayesian inference [2]. Therefore, it is natural that in the past few years there have been intensive efforts on exact and approximation algorithms for these kinds of problems. Exact algorithms have been proposed for solving the problems restricted to special classes of graphs as well as several approximation algorithms with provable bounds for the cases that are not known to be polynomially solvable. The most general feedback set problem consists in finding a minimum-weight (or minimum cardinality) set of vertices (arcs) that meets all cycles in a collection C of cycles in a graph (G,w), where w is a nonnegative function defined on th..