The Transmission of Vowel Harmony and Vowel Disharmony: An Iterated Learning Study

Substantive bias affects phonological acquisition in a way that learners may more readily learn phonetically motivated patterns. Some previous experimental work has proved the effect of substantive bias in a synchronic context, whereas how the bias influences diachronic changes has hardly been studied. This paper investigates the role of substantive bias in phonological transmission. We employed the iterated learning paradigm to compare the transmissions of two artificial languages exhibiting vowel harmony (phonetically natural) or vowel disharmony (phonetically unnatural). In general, participants performed equally well in the two conditions, and the proportions of the two patterns showed a similar decreasing tendency over generations, suggesting no bias effect in the process of language transmission

Assessing competitiveness of foreign and local supermarket chains in Vietnamese market by using Fuzzy TOPSIS method

Considering the strategic importance for supermarket chains and to understanding the critical elements affecting their competitiveness and their relative level of competitiveness, this study tries to assess competitiveness of foreign and local supermarket chains in Vietnam using the fuzzy TOPSIS method. The results show that, even smaller size Vietnamese supermarket chains, when compared to foreign chains, are still slightly higher in competitiveness.Competitiveness; Supermarket chains; Fuzzy TOPSIS

YY1 is autoregulated through its own DNA-binding sites

<p>Abstract</p> <p>Background</p> <p>The transcription factor Yin Yang 1 (YY1) is a ubiquitously expressed, multifunctional protein that controls a large number of genes and biological processes in vertebrates. As a general transcription factor, the proper levels of YY1 protein need to be maintained for the normal function of cells and organisms. However, the mechanism for the YY1 homeostasis is currently unknown.</p> <p>Results</p> <p>The current study reports that the YY1 gene locus of all vertebrates contains a cluster of its own DNA-binding sites within the 1^stintron. The intact structure of these DNA-binding sites is absolutely necessary for transcriptional activity of the YY1 promoter. In an inducible cell line system that over-expresses an exogenous YY1 gene, the overall increased levels of YY1 protein caused a reduction in transcription levels of the endogenous YY1 gene. Reversion to the normal levels of YY1 protein restored the transcriptional levels of the endogenous YY1 to normal levels. This homeostatic response was also mediated through its cluster of YY1 binding sites.</p> <p>Conclusion</p> <p>Taken together, the transcriptional level of YY1 is self-regulated through its internal DNA-binding sites. This study identifies YY1 as the first known autoregulating transcription factor in mammalian genomes.</p