Pharmacological effects of aqueous–ethanolic extract of Hibiscus rosasinensis on volume and acidity of stimulated gastric secretion

ObjectiveTo explore the effects of extract of Hibiscus rosasinensis (H. rosasinensis) on the volume, free and total acidity of gastric secretion induced by carbachol.MethodsAnimals were kept on fasting for 48 h, then the pylorus of each animal was ligated. They were randomly divided into 5 groups and treated by carbachol at 600 μg/kg. Then animals in group II – V were treated by H. rosasinensis extract at 250 and 500 mg/kg body weight, cimetidine at 2.5 mg/kg and verapamil at 10 mg/kg body weight intraperitoneally, respectively. The volume, free and total acidity of gastric secretion were observed and compared.ResultsIt was found that the extract significantly reduced the volume, free and total acidity of gastric secretion (P<0.01). These reductions were comparable to cimetidine and verapamil. And the reduction in the volume and free acidity were more significant in cimetidine and verapamil treated group indicating that cimetidine and verapamil were more effective.ConclusionsThe extract of H. rosasinensis can reduced the volume, free and total acidity of gastric secretion, and can be used effectively in the treatment of peptic ulcer

Wound healing properties of Henna leaves

406-412Wound healing potential of different extracts of henna leaves i.e. Lawsonia inermis Linn. was evaluated on the rat excision and incision wound models. Lawsone isolated from the leaves was also screened for same pharmacological activity. It was observed that the oral administration as well as topical application of ethanol extract of henna leaves and lawsone exhibited significant healing response in both the wound models. Further, it was found that the topical application of ethanol extract as well as isolated lawsone was more effective than the same given by the oral route. Thus, topical application of ethanol extract can be successfully formulated for the wound healing activity