28 research outputs found
Influence of Deleterious Phases Precipitation in the Corrosion Resistance Measured by Double Loop Electrochemical Polarization Reactivation Test in Superduplex Stainless Steel
Effect of Cooling Rate on the Corrosion Behavior of As-Cast SAF 2205 Duplex Stainless Steel After Solution Annealing Treatment
Double Kinetics of Intermetallic Phase Precipitation in UNS S32205 Duplex Stainless Steels Submitted to Isothermal Heat Treatment
Effects of post weld heat treatments on the microstructure and mechanical properties of dissimilar weld of supermartensític stainless steel
Naphthenic corrosion resistance, mechanical properties and microstructure evolution of experimental Cr-Mo steels with high Mo content
Effect of thermal aging conditions on the corrosion properties and hardness of a duplex stainless steel
Sigma Phase in Superduplex Stainless Steel: Formation, Kinetics and Microstructural Path
Effect of Continuous Cooling on Secondary Phase Precipitation in the Super Duplex Stainless Steel ZERON-100
Effects of 2-hydroxyoleic acid on the structural properties of biological and model plasma membranes
Genetic hypertension is associated with alterations in lipid metabolism, membrane lipid composition and membrane-protein function. 2-Hydroxyoleic acid (2OHOA) is a new antihypertensive molecule that regulates the structure of model membranes and their interaction with certain peripheral signalling proteins in vitro. While the effect of 2OHOA on elevated blood pressure is thought to arise through its influence on signalling proteins, its effects on membrane lipid composition remain to be assessed. 2OHOA administration altered the lipid membrane composition of hypertensive and normotensive rat plasma membranes, and increased the fluidity of reconstituted liver membranes from hypertensive rats. In spontaneously hypertensive rats (SHR), treatment with 2OHOA increased the cholesterol and sphingomyelin content while decreasing that of phosphatidylserine-phosphatidylinositol lipids. In addition, monounsaturated fatty acid levels increased as well as the propensity of reconstituted membranes to form HII-phases. These data suggest that 2OHOA regulates lipid metabolism that is altered in hypertensive animals, and that it affects the structural properties of liver plasma membranes in SHR. These changes in the structural properties of the plasma membrane may modulate the activity of signalling proteins that associate with the cell membrane such as the Galphaq/11 protein and hence, signal transduction