Improved spatial resolution of elemental maps through inversion of LA-ICP-MS data

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) provides the spatial distribution of elements within crystals and therefore can constrain the rates of geological processes. Spatial resolution of LA-ICP-MS is limited by the requirement to ablate sufficient material to surpass the detection limit of the instrument: too little material and the concentration cannot be measured; too much material from the same spatial location and the possibility of depth dependent variations in concentration increases. Because of this requirement and typical analytical setup, this commonly places a lower bound on the diameter of an ablation ‘spot’ size of approximately 20 μm for elements with ppm concentration. Here we present a means to achieve sub-spot size resolution using inverse methods. We discretize the space sampled in an analysis into pixels and note that the average concentration of the pixels sampled by a spot equals the measured concentration. As multiple overlapping spots sample some of the same pixels, we can combine discrete expressions for each spot as a system of linear equations. Through linear inversion with smoothness constraints we can solve for unknown pixel concentrations. We highlight this approach with two natural examples in which diffusive processes are important: magmatic ascent speeds and (U-Th)/He noble gas thermochronometry. In these examples, accurate results require that the true concentration gradients can be recovered from LA-ICP-MS data. We show that the ability to infer rapid rates of magma ascent is improved from months to weeks and that we are able to interpret previously un-interpretable thermochronometric data

Detrital Thermochronometry Reveals That the Topography Along the Antarctic Peninsula is Not a Pleistocene Landscape

Using offshore detrital apatite (U‐Th)/He thermochronometry and 3D thermo‐kinematic modeling of the catchment topography, we constrain the timing of major topographic change at Bourgeois Fjord, Antarctic Peninsula (AP). While many mid‐latitude glacial landscapes developed primarily in response to global cooling over the last ~2.6 Ma, we find that kilometer‐scale landscape evolution at Bourgeois Fjord began ~30–12 Ma ago and <2 km of valley incision has occurred since ~16 Ma. This early onset of major topographic change occurred following the initiation of alpine glaciation at this location and prior to the development of a regional polythermal ice sheet inferred from sedimentary evidence offshore of the AP. We hypothesize that topographic change relates to (i) feedbacks between an evolving topography and glacial erosion processes, (ii) effects of glacial‐interglacial variability, and (iii) the prevalence of subglacial meltwater. The timing and inferred spatial patterns of long‐term exhumation at Bourgeois Fjord are consistent with a hypothesis that glacial erosion processes were suppressed at the AP during global Plio‐Pleistocene cooling, rather than enhanced. Our study examines the long‐term consequences of glacial processes on catchment‐wide erosion as the local climate cooled. Our findings support the hypothesis that landscapes at different latitudes had different responses to global cooling. Our results also suggest that erosion is enhanced along the plateau flanks of Bourgeois Fjord today, which may be due to periglacial processes or mantling via subglacial till. If regional warming persists and meltwater becomes more pronounced, we predict that enhanced erosion along the plateau flank will accelerate topographic change

Late Cenozoic deepening of Yosemite Valley, USA

Although Yosemite Valley, USA, catalyzed the modern environmental movement and fueled foundational debates in geomorphology, a century of investigation has failed to definitively determine when it formed. The non-depositional nature of the landscape and homogeneous bedrock have prevented direct geological assessments. Indirect assumptions about the age of downcutting have ranged from pre-Eocene to Pleistocene. Clarity on this issue would not only satisfy public interest but also provide a new constraint for contentious debates about the Cenozoic tectonic and geomorphologic history of the Sierra Nevada in California. Here we use thermochronometric analysis of radiogenic helium in apatite crystals, coupled with numerical models of crustal temperatures beneath evolving topography, to demonstrate significant late Cenozoic deepening of Tenaya Canyon, Yosemite’s northeastern branch. Approximately 40%–90% of the current relief has developed since 10 Ma and most likely since 5 Ma. This coincides with renewed regional tectonism, which is a long-hypothesized but much debated driver of Sierran canyon development. Pleistocene glaciation caused spatially variable incision and valley widening in Yosemite Valley, whereas little contemporaneous erosion occurred in the adjacent upper Tuolumne watershed. Such variations probably arise from glacial erosion’s dependence on topographic focusing of ice discharge into zones of rapid flow, and on the abundance of pre-existing fractures in the substrate. All available data, including those from our study, are consistent with a moderately high and slowly eroding mid-Cenozoic Sierra Nevada followed by significant late Cenozoic incision of some, but not all, west-side canyon

A helium-based model for the effects of radiation damage annealing on helium diffusion kinetics in apatite

Widely used to study surface processes and the development of topography through geologic time, (U–Th)/He thermochronometry in apatite depends on a quantitative description of the kinetics of 4He diffusion across a range of temperatures, timescales, and geologic scenarios. Empirical observations demonstrate that He diffusivity in apatite is not solely a function of temperature, but also depends on damage to the crystal structure from radioactive decay processes. Commonly-used models accounting for the influence of thermal annealing of radiation damage on He diffusivity assume the net effects evolve in proportion to the rate of fission track annealing, although the majority of radiation damage results from α-recoil. While existing models adequately quantify the net effects of damage annealing in many geologic scenarios, experimental work suggests different annealing rates for the two damage types. Here, we introduce an alpha-damage annealing model (ADAM) that is independent of fission track annealing kinetics, and directly quantifies the influence of thermal annealing on He diffusivity in apatite. We present an empirical fit to diffusion kinetics data and incorporate this fit into a model that tracks the competing effects of radiation damage accumulation and annealing on He diffusivity in apatite through geologic time. Using time–temperature paths to illustrate differences between models, we highlight the influence of damage annealing on data interpretation. In certain, but not all, geologic scenarios, the interpretation of low-temperature thermochronometric data can be strongly influenced by which model of radiation damage annealing is assumed. In particular, geologic scenarios involving 1–2 km of sedimentary burial are especially sensitive to the assumed rate of annealing and its influence on He diffusivity. In cases such as basement rocks in Grand Canyon and the Canadian Shield, (U–Th)/He ages predicted from the ADAM can differ by hundreds of Ma from those predicted by other models for a given thermal path involving extended residence between ∼40–80 °C

Westernmost Grand Canyon incision: Testing thermochronometric resolution

The timing of carving of Grand Canyon has been debated for over 100 years with competing endmember hypotheses advocating for either a 70 Ma (“old”) or <6 Ma (“young”) Grand Canyon. Several geological constraints appear to support a “young” canyon model, but thermochronometric measures of cooling history and corresponding estimates of landscape evolution have been in debate. In particular, 4He/3He thermochronometric data record the distribution of radiogenic 4He (from the 238U, 235U and 232Th decay series) within an individual apatite crystal and thus are highly sensitive to the thermal history corresponding to landscape evolution. However, there are several complicating factors that make interpreting such data challenging in geologic scenarios involving reheating. Here, we analyze new data that provide measures of the cooling of basement rocks at the base of westernmost Grand Canyon, and use these data as a testbed for exploring the resolving power and limitations of 4He/3He data in general. We explore a range of thermal histories and find that these data are most consistent with a “young” Grand Canyon. A problem with the recovered thermal history, however, is that burial temperatures are under predicted based on sedimentological evidence. A solution to this problem is to increase the resistance of alpha recoil damage to annealing, thus modifying He diffusion kinetics, allowing for higher temperatures throughout the thermal history. This limitation in quantifying radiation damage (and hence crystal retentivity) introduces non-uniqueness to interpreting time–temperature paths in rocks that resided in the apatite helium partial retention zone for long durations. Another source of non-uniqueness, is due to unknown U and Th distributions within crystals. We show that for highly zoned with a decrease in effective U of 20 ppm over the outer 80% of the radius of the crystal, the 4He/3He data could be consistent with an “old” canyon model. To reduce this non-uniqueness, we obtain U and Th zonation information for separate crystals from the same rock sample through LA-ICP-MS analysis. The observed U and Th distributions are relatively uniform and not strongly zoned, thus supporting a “young” canyon model interpretation of the 4He/3He data. Furthermore, we show that for the mapped zonation, the difference between predicted 4He/3He data for a uniform crystal and a 3D model of the crystal are minimal, highlighting that zonation is unlikely to lead us to falsely infer an “old” Grand Canyon

6 Ma age of carving Westernmost Grand Canyon: Reconciling geologic data with combined AFT, (U-Th)/He, and He-4/He-3 thermochronologic data

Conflicting hypotheses about the timing of carving of the Grand Canyon involve either a 70 Ma (“old”) or <6 Ma (“young”) Grand Canyon. This paper evaluates the controversial westernmost segment of the Grand Canyon where the following lines of published evidence firmly favor a “young” Canyon. 1) North-derived Paleocene Hindu Fanglomerate was deposited across the present track of the westernmost Grand Canyon, which therefore was not present at ∼55 Ma. 2) The 19 Ma Separation Point basalt is stranded between high relief side canyons feeding the main stem of the Colorado River and was emplaced before these tributaries and the main canyon were incised. 3) Geomorphic constraints indicate that relief generation in tributaries and on plateaus adjacent to the westernmost Grand Canyon took place after 17 Ma. 4) The late Miocene–Pliocene Muddy Creek Formation constraint shows that no river carrying far-traveled materials exited at the mouth of the Grand Canyon until after 6 Ma. Interpretations of previously-published low-temperature thermochronologic data conflict with these lines of evidence, but are reconciled in this paper via the integration of three methods of analyses on the same sample: apatite (U–Th)/He ages (AHe), 4He/3He thermochronometry (4He/3He), and apatite fission-track ages and lengths (AFT). HeFTy software was used to generate time–temperature (t–T) paths that predict all new and published 4He/3He, AHe, and AFT data to within assumed uncertainties. These t–T paths show cooling from ∼100 °C to 40–60 °C in the Laramide (70–50 Ma), long-term residence at 40–60 °C in the mid-Tertiary (50–10 Ma), and cooling to near-surface temperatures after 10 Ma, and thus support young incision of the westernmost Grand Canyon. A subset of AHe data, when interpreted alone (i.e. without 4He/3He or AFT data), are better predicted by t–T paths that cool to surface temperatures during the Laramide, consistent with an “old” Grand Canyon. However, the combined AFT, AHe, and 4He/3He analysis of a key sample from Separation Canyon can only be reconciled by a “young” Canyon. Additional new AFT (5 samples) and AHe data (3 samples) in several locations along the canyon corridor also support a “young” Canyon. This inconsistency, which mimics the overall controversy of the age of the Grand Canyon, is reconciled here by optimizing cooling paths so they are most consistent with multiple thermochronometers from the same rocks. To do this, we adjusted model parameters and uncertainties to account for uncertainty in the rate of radiation damage annealing in these apatites during sedimentary burial and the resulting variations in He retentivity. In westernmost Grand Canyon, peak burial conditions (temperature and duration) during the Laramide were likely insufficient to fully anneal radiation damage that accumulated during prolonged, near-surface residence since the Proterozoic. We conclude that application of multiple thermochronometers from common rocks reconciles conflicting thermochronologic interpretations and the data presented here are best explained by a “young” westernmost Grand Canyon. Samples spread along the river corridor also suggest the possibility of variable mid-Tertiary thermal histories beneath north-retreating cliffs

Ubiquitous molecular substrates for associative learning and activity-dependent neuronal facilitation.

Recent evidence suggests that many of the molecular cascades and substrates that contribute to learning-related forms of neuronal plasticity may be conserved across ostensibly disparate model systems. Notably, the facilitation of neuronal excitability and synaptic transmission that contribute to associative learning in Aplysia and Hermissenda, as well as associative LTP in hippocampal CA1 cells, all require (or are enhanced by) the convergence of a transient elevation in intracellular Ca2+ with transmitter binding to metabotropic cell-surface receptors. This temporal convergence of Ca2+ and G-protein-stimulated second-messenger cascades synergistically stimulates several classes of serine/threonine protein kinases, which in turn modulate receptor function or cell excitability through the phosphorylation of ion channels. We present a summary of the biophysical and molecular constituents of neuronal and synaptic facilitation in each of these three model systems. Although specific components of the underlying molecular cascades differ across these three systems, fundamental aspects of these cascades are widely conserved, leading to the conclusion that the conceptual semblance of these superficially disparate systems is far greater than is generally acknowledged. We suggest that the elucidation of mechanistic similarities between different systems will ultimately fulfill the goal of the model systems approach, that is, the description of critical and ubiquitous features of neuronal and synaptic events that contribute to memory induction

Ensuring competency in end-of-life care: controlling symptoms

BACKGROUND: Palliative medicine is assuming an increasingly important role in patient care. The Education for Physicians in End-of-life Care (EPEC) Project is an ambitious program to increase core palliative care skills for all physicians. It is not intended to transmit specialty level competencies in palliative care. METHOD: The EPEC Curriculum was developed to be a comprehensive syllabus including trainer notes, multiple approaches to teaching the material, slides, and videos of clinical encounters to trigger discussion are provided. The content was developed through a combination of expert opinion, participant feedback and selected literature review. Content development was guided by the goal of teaching core competencies not included in the training of generalist and non-palliative medicine specialist physicians. RESULTS: Whole patient assessment forms the basis for good symptom control. Approaches to the medical management of pain, depression, anxiety, breathlessness (dyspnea), nausea/vomiting, constipation, fatigue/weakness and the symptoms common during the last hours of life are described. CONCLUSION: While some physicians will have specialist palliative care services upon which to call, most in the world will need to provide the initial approaches to symptom control at the end-of-life