Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice

Regulatory T cells (Tregs) are a double-edged regulator of the immune system. Aberrations of Tregs correlate with pathogenesis of inflammatory, autoimmune and neoplastic disorders. Phenotypically and functionally distinct subsets of Tregs have been identified in humans and mice on the basis of their extensive portfolios of monoclonal antibodies (mAb) against Treg surface antigens. As an important veterinary species, dogs are increasingly recognised as an excellent model for many human diseases. However, insightful study of canine Tregs has been restrained by the limited availability of mAb. We therefore set out to characterise CD4+CD25high T cells isolated ex vivo from healthy dogs and showed that they possess a regulatory phenotype, function, and transcriptomic signature that resembles those of human and murine Tregs. By launching a cross-species comparison, we unveiled a conserved transcriptomic signature of Tregs and identified that transcript hip1 may have implications in Treg function

Knowledge and Skills of a Logistics Manager Required by the Manufacturing Industry of Ciudad Juárez

This chapter presents a model that integrates six main skills and/or knowledge that a logistics professional should have. This model is validated through the confirmatory factorial analysis technique. The research work was carried out specifically in the Export Manufacturing Industry of Ciudad Juárez, Chihuahua, applying a questionnaire of 33 items to the personnel of the medium and high levels responsible for the logistics area. The results indicate that the factors with the greatest explanatory power are: Information technology, Supply chain management and Quantitative methods