13 research outputs found
From the stable to the exotic: clustering in light nuclei
A great deal of research work has been undertaken in alpha-clustering study
since the pioneering discovery of 12C+12C molecular resonances half a century
ago. Our knowledge on physics of nuclear molecules has increased considerably
and nuclear clustering remains one of the most fruitful domains of nuclear
physics, facing some of the greatest challenges and opportunities in the years
ahead. The occurrence of "exotic" shapes in light N=Z alpha-like nuclei is
investigated. Various approaches of the superdeformed and hyperdeformed bands
associated with quasimolecular resonant structures are presented. Evolution of
clustering from stability to the drip-lines is examined: clustering aspects
are, in particular, discussed for light exotic nuclei with large neutron excess
such as neutron-rich Oxygen isotopes with their complete spectroscopy.Comment: 15 pages, 5 figures, Presented at the International Symposium on "New
Horizons in Fundamental Physics - From Neutrons Nuclei via Superheavy
Elements and Supercritical Fields to Neutron Stars and Cosmic Rays" held at
Makutsi Safari Farm, South Africa, December 23-29, 2015. arXiv admin note:
substantial text overlap with arXiv:1402.6590, arXiv:1303.0960,
arXiv:1408.0684, arXiv:1011.342
A transcription factor PU.1 is critical for Ccl22 gene expression in dendritic cells and macrophages
Surface profiling of extracellular vesicles from plasma or ascites fluid using DotScan antibody microarrays
DotScan antibody microarrays were initially developed for the extensive surface profiling of live leukemia and lymphoma cells. DotScanâs diagnostic capability was validated with an extensive clinical trial using mononuclear cells from the blood or bone marrow of leukemia or lymphoma patients. DotScan has also been used for the profiling of surface proteins on peripheral blood mononuclear cells (PBMC) from patients with HIV, liver disease, and stable and progressive B-cell chronic lymphocytic leukemia (CLL). Fluorescence multiplexing allowed the simultaneous profiling of cancer cells and leukocytes from disaggregated colorectal and melanoma tumor biopsies after capture on DotScan. In this chapter, we have used DotScan for the surface profiling of extracellular vesicles (EV) recovered from conditioned growth medium of cancer cell lines and the blood of patients with CLL. The detection of captured EV was performed by enhanced chemiluminescence (ECL) using biotinylated antibodies that recognized antigens expressed on the surface of the EV subset of interest. DotScan was also used to profile EV from the blood of healthy individuals and the ascites fluid of ovarian cancer patients. DotScan binding patterns of EV from human plasma and other body fluids may yield diagnostic or prognostic signatures for monitoring the incidence, treatment, and progression of cancers