9 research outputs found
Detailed multi-zone thermodynamic simulation for direct-injection diesel engine combustion
Trans-patella tendon approach for domed lateral unicompartmental knee arthroplasty does not increase the risk of patella tendon shortening
Endogenous CNS Expression of Neurotensin and Neurotensin Receptors Is Altered during the Postpartum Period in Outbred Mice
Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice
Pathophysiology of T follicular helper cells in humans and mice
Follicular helper T cells (TFH cells) compose a heterogeneous subset of CD4(+) T cells that induce the differentiation of B cells into plasma cells and memory cells. They are found within and in proximity to germinal centers in secondary lymphoid organs, and their memory compartment also circulates in the blood. Our knowledge on the biology of TFH cells has increased significantly during the past decade, largely as a result of mouse studies. However, recent studies on human TFH cells isolated from lymphoid organ and blood samples and recent observations on the developmental mechanism of human TFH cells have revealed both similarities and differences between human and mouse TFH cells. Here we present the similarities and differences between mouse and human lymphoid organ-resident TFH cells and discuss the role of TFH cells in response to vaccines and in disease pathogenesis.Supported by the US National Institutes of Health (U19-AI057234, U19-AI082715
and U19-AI089987), the Alliance for Lupus Research, the Baylor Health Care
System (H.U.) and the Australian National Health and Medical Research
Council (C.G.V.)