Phosphoinositide 3-kinase controls early and late events in mammalian cell division

Phosphoinositide 3-kinase (PI3K) plays a crucial role in triggering cell division. To initiate this process, PI3K induces two distinct routes, of which one promotes cell growth and the other regulates cyclin-dependent kinases. Fine-tuned PI3K regulation is also required for later cell cycle phases. Here, we review the multiple points at which PI3K controls cell division and discuss its impact on human cancer

Entrepreneurial Competences: Comparing and Contrasting Models and Taxonomies

The emphasis on competencies as capturing key aspects of entrepreneurship is relatively recent and quite distinct from research on entrepreneurial traits or cognitive styles in that competencies represent observable and measurable knowledge, behaviour, attitudes and skills. Many competency taxonomies and models have been proposed by scholars, as frameworks organized into tiers of competencies including descriptions of the activities and behaviours associated with that competency (Chouhan & Srivastava, 2014). However, no comprehensive set of entrepreneurial competencies has emerged from these distinctions and no or little empirical evidence has been provided to validate these categorizations (Morris et al., 2013). This study compares and contrasts three traditional models (Morris et al., 2013, Bartram\u2019s 2005, with the EU Entrepreneurship Competence Framework; EntreComp, Bacigalupo et al., 2016) previously empirically validated by the author