16 research outputs found
With whom to merge? A tale of the Spanish banking deregulation process
Branch deregulation, Mergers, Optimal behavior, Spanish Banking System, C72, G21, G28, L13, L41, L51,
Why Do Japanese Non-Local Regional Banks Enter Other Prefectures Under the Region-Based Relationship Banking Policy?
Interleukin-1 Gene Cluster Polymorphisms and its Haplotypes may Predict the Risk to Develop Cervical Cancer in Tunisia
Microfacies analysis, diagenetic overprints, geochemistry, and reservoir quality of the Jurassic Samanasuk Formation at the Kahi Section, Nizampur Basin, NW Himalayas, Pakistan
The Extracellular Matrix, Growth Factors and Morphogens in Biomaterial Design and Tissue Engineering
Cells, morphogens, growth factors, and custom scaffolds are the critical ingredients for successful tissue regeneration in which morphogens and growth factors function sequentially. Extensive studies, in vitro and in vivo, have been made to explore the mechanisms and the roles played by these molecules. As a consequence, precise, localized control over the signaling of these factors and appropriate strategy selection, depending on the tissue or organ to be repaired or regenerated, is known to permit specific management of regenerative processes. The first part of the chapter examines natural ECMs which are a set of molecules secreted by cells that provide structural and biochemical support to the surrounding cells. ECMs also perform many other functions, such as actively regulating cell function through the control of biochemical gradients, cell density, spatial organization, and ligand attachment, thus influencing various types of cell processes. Subsequently, growth factors and morphogens are examined in greater depth to clarify to what degree progress has been made into improving methodologies and functionality and, perhaps, to hint at what remains to be done for the future of tissue engineering