Green tea halts progression of cardiac transthyretin amyloidosis: an observational report

BACKGROUND: Treatment options in patients with amyloidotic transthyretin (ATTR) cardiomyopathy are limited. Epigallocatechin-3-gallate (EGCG), the most abundant catechin in green tea (GT), inhibits fibril formation from several amyloidogenic proteins in vitro. Thus, it might also halt progression of TTR amyloidosis. This is a single-center observational report on the effects of GT consumption in patients with ATTR cardiomopathy. METHODS: 19 patients with ATTR cardiomyopathy were evaluated by standard blood tests, echocardiography, and cardiac MRI (n = 9) before and after consumption of GT and/or green tea extracts (GTE) for 12 months. RESULTS: Five patients were not followed up for reasons of death (n = 2), discontinuation of GT/GTE consumption (n = 2), and heart transplantation (n = 1). After 12 months no increase of left ventricular (LV) wall thickness and LV myocardial mass was observed by echocardiography. In the subgroup of patients evaluated by cardiac MRI a mean decrease of LV myocardial mass (-12.5 %) was detected in all patients. This was accompanied by an increase of mean mitral annular systolic velocity of 9 % in all 14 patients. Total cholesterol (191.9 ± 8.9 vs. 172.7 ± 9.4 mg/dL; p < 0.01) and LDL cholesterol (105.8 ± 7.6 vs. 89.5 ± 8.0 mg/dL; p < 0.01) decreased significantly during the observational period. No serious adverse effects were reported by any of the participants. CONCLUSIONS: Our observation suggests an inhibitory effect of GT and/or GTE on the progression of cardiac amyloidosis. We propose a randomized placebo-controlled investigation to confirm our observation

Does the Constitution Provide More Ballot Access Protection for Presidential Elections Than for U.S. House Elections?

Both the U.S. Constitution and The Federalist Papers suggest that voters ought to have more freedom to vote for the candidate of their choice for the U.S. House of Representatives than they do for the President or the U.S. Senate. Yet, strangely, for the last thirty-three years, the U.S. Supreme Court and lower courts have ruled that the Constitution gives voters more freedom to vote for the candidate of their choice in presidential elections than in congressional elections. Also, state legislatures, which have been writing ballot access laws since 1888, have passed laws that make it easier for minor-party and independent candidates to get on the ballot for President than for the U.S. House. As a result, voters in virtually every state invariably have far more choices on their general election ballots for the President than they do for the House. This Article argues that the right of a voter to vote for someone other than a Democrat or a Republican for the House is just as important as a voter’s right to do so for President, and that courts should grant more ballot access protection to minor-party and independent candidates for the House

Cultivares de trigo: Embrapa.

Qualidade industrial. Semeadura. Regiões de adaptação. Profundidade. Espaçamento. Densidade. Rendimento de grãos. Reação a doenças.bitstream/item/59065/1/Documentos-307.pd

BRS 378RR: versatilidade nos sistemas de produção.

Precocidade: a BRS 378RR é uma soja precoce, com boa sanidade, grão graúdo e bom porte. Versátil nos sistemas de produção para a macrorregião sojícola 1. Regiões edafoclimáticas de adaptação. Alto peso de grãos. Grupo de maturidade relativa. Características. Época de semeadura. Sanidade: reação a doenças. Ciclo, acamamento e densidade de semeadura.bitstream/item/92221/1/folder-BRS-378RR-V01.pdf1 folder

Cultivares de soja: MACRORREGIÕES 1, 2, 3 e REC 401: Centro-Sul do Brasil.

Indicação de cultivares por região edafoclimática, Indicação de cultivares, Época de semeadura, População de plantas e densidade de semeadura, Peso médio de sementes, Mancha olho-de-rã, Cancro da haste, Podridão radicular de PHYTOPHTHORA, Oídio, Ferrugem-asiática da soja, Fitonematoides, Cultivares de Soja Convencional, Cultivares de Soja Transgênica RR, Cultivares de Soja Transgênica Intacta RR2 PROtm, Colaboradores da Fundação Meridional.bitstream/item/162217/1/Catalogo-4-Livreto-Soja-FM-2017-OL.pdfCatálogo 04/2017