A common genetic network underlies substance use disorders and disruptive or externalizing disorders

Here we summarize evidence obtained by our group during the last two decades, and contrasted it with a review of related data from the available literature to show that behavioral syndromes involving attention deficit/hyperactivity disorder (ADHD), externalizing disorders, and substance-use disorder (SUD) share similar signs and symptoms (i.e., have a biological basis as common syndromes), physiopathological and psychopathological mechanisms, and genetic factors. Furthermore, we will show that the same genetic variants harbored in different genes are associated with different syndromes and that non-linear interactions between genetic variants (epistasis) best explain phenotype severity, long-term outcome, and response to treatment. These data have been depicted in our studies by extended pedigrees, where ADHD, externalizing symptoms, and SUD segregate and co-segregate. Finally, we applied here a new formal network analysis using the set of significantly replicated genes that have been shown to be either associated and/or linked to ADHD, disruptive behaviors, and SUD in order to detect significantly enriched gene categories for protein and genetic interactions, pathways, co-expression, co-localization, and protein domain similarity. We found that networks related to pathways involved in axon guidance, regulation of synaptic transmission, and regulation of transmission of nerve impulse are overrepresented. In summary, we provide compiled evidence of complex networks of genotypes underlying a wide phenotype that involves SUD and externalizing disorders

Adolescent Brain Development and the Risk for Alcohol and Other Drug Problems

Dynamic changes in neurochemistry, fiber architecture, and tissue composition occur in the adolescent brain. The course of these maturational processes is being charted with greater specificity, owing to advances in neuroimaging and indicate grey matter volume reductions and protracted development of white matter in regions known to support complex cognition and behavior. Though fronto-subcortical circuitry development is notable during adolescence, asynchronous maturation of prefrontal and limbic systems may render youth more vulnerable to risky behaviors such as substance use. Indeed, binge-pattern alcohol consumption and comorbid marijuana use are common among adolescents, and are associated with neural consequences. This review summarizes the unique characteristics of adolescent brain development, particularly aspects that predispose individuals to reward seeking and risky choices during this phase of life, and discusses the influence of substance use on neuromaturation. Together, findings in this arena underscore the importance of refined research and programming efforts in adolescent health and interventional needs

SOX and the Regulation of the Accounting Industry

A significant portion of SOX focuses on ensuring better financial disclosure by enhancing the regulation of outside auditors and the accounting process. For example, the Act not only created the Public Company Accounting Oversight Board ( PCAOB ) to oversee public auditors, but also required that public companies implement a system to evaluate the effectiveness of their internal controls as they relate to financial reporting. This panel explores the impact of SOX on financial accounting and the accounting industry. It also examines lessons learned from implementing SOX\u27s various accounting provisions and how those lessons should shape the application of SOX in the future

Subcellular localization of Myogenic Regulatory Factors along skeletal muscle development.

Myogenesis is a multistep process controlled by a transcriptional cascade in which myogenesis regulatory factors (MRFs) have a crucial role [1]. MRFs are a family of basic helix-loop-helix proteins, composed by Myo-D, Myf-5, Myogenin and MRF-4 [2]. They are not activated at the same time: in fact, Myo-D and Myf-5 induce differentiation at earlier step, while Myogenin and MRF-4 are important for myotube formation and for myogenic lineage maintenance [2,3]. C2C12 are murine myoblasts derived from satellite cells and their behaviour corresponds to that of progenitor lineage. They are a subclone of C2 myoblast which spontaneously differentiates in culture after serum removal [5]

Growth performance and carcass characteristics of female turkeys as affected by feeding programs

A trial was conducted to evaluate the effects of different feeding programs on growth performance and carcass characteristics of Nicholas Large White female turkeys. Three different feeding programs were considered for a 12-wk period: 1) 3 diets fed for 4 wk each (starter 24% CP, grower 20% CP, and finisher diet 16% CP), 2) 2 diets fed for 6 wk each (startergrower 22% CP and grower-finisher diet 18% CP), and 3) no change of diet for 12 wk (starter-grower-finisher diet 20% CP). From 0 to 4 wk of age, birds were fed an ad libitum common starter diet. Each dietary treatment was replicated 3 times, and feed and water were provided ad libitum. Body weight and feed consumption were measured every 2 wk, whereas carcass characteristics were evaluated at 16 wk of age. Feed intake increased as the frequency of dietary changes decreased, and feed conversion was not different between programs 1 and 3. There were no significant differences in final BW among experimental groups. For a single feeding program, the proportion of neck, bone, and feet decreased, and a greater percentage of edible meat was registered as compared with the other 2 groups. Mean carcass, breast, and thigh weights of turkeys reared under multiple diets were not different compared with other groups. Positive correlations were noted between live weight and weight of carcass, breast, thigh, drumstick, wing, and abdominal fat of turkeys. Thus, a single cycle feeding regimen in Nicholas Large White female turkeys results in similar growth performance and carcass characteristics compared with other conventional feeding programs considered in the present study