9 research outputs found
PRIMARY EXTRAMEDULLARY PLASMACYTOMA IN THE MIDDLE-EAR - DIFFERENTIAL-DIAGNOSIS AND MANAGEMENT
Primary extramedullary plasmacytoma (PEP) is an uncommon neoplasm of
plasma cell origin which afflicts the head and neck mainly. In this
study we report a rare case of a 34-year-old man who presented with left
ear tinnitus, hearing loss, blocked feeling and headache. Exploratory
tympanotomy revealed a mass extending into the attic and the mastoid
antrum. Following canal wall-up mastoidectomy, the tumour was carefully
removed. Histological examination (including immunoperoxidase staining)
and thorough clinical, laboratory and radiological evaluation revealed
an exclusively cytoplasmic monoclonal IgG immunoglobulin PEP. The
combination of surgery (including a second-look procedure) and
radiotherapy used in this case may be an over-treatment. However, the
patient is still disease-free seven years after his first admission to
hospital
Middle ear adenomatous tumor with a predominant neuroendocrine component
A primary adenomatous tumor of the middle ear was examined by light
microscopy, ultrastructural and immunohistochemical techniques. In
support of its extensive neuroendocrine differentiation, was the diffuse
detection of neuron-specific enolase (NSE) and positive immunoreaction
with antibodies to chromogranin and synaptophysin. The great majority of
tumor cells contained neurosecretory granules and intraluminal mucin
production could be focally detected. These characteristics confirm the
diagnosis of a middle ear adenomatous tumor (MEAT) of a biphasic nature
and with a prominent neuroendocrine component
Auditory function in young patients with chronic renal failure
Debate on the relationship between renal insufficiency and hearing loss
continues mainly due to the advanced age and the possible accelerated
presbycusis of the patients that have been studied in surveys. Hearing
acuity was studied in 46 children and adolescents suffering from renal
insufficiency. Sensorineural hearing loss (mainly high-frequency) of
unknown cause was found in 14 patients (30.4%). Hearing loss was not
influenced by the various haematological, biochemical and clinical
parameters (type of renal disease, blood pressure, history of ototoxic
drugs administration). However, hearing loss seemed to be affected by
the method of management of the renal insufficiency (more in the
haemodialysis group than in the peritoneal dialysis group). There were
no significant changes in audiometric findings before and after
haemodialysis
Tuberculose faringolaríngea Laryngo-pharyngeal Tuberculosis
A apresentação faringolaríngea da tuberculose como forma isolada da doença é rara, entretanto, nos últimos anos, com o aumento progressivo do número de casos de tuberculose em geral, a possibilidade dessas localizações aumentou. OBJETIVO: Descrever caso de tuberculose faringolaríngea primária em paciente grávida e imunocompetente. RELATORIO DE CASO: Paciente do sexo feminino, 30 anos, com história de odinofagia há 10 meses, sem qualquer sintoma sistêmico ou outras queixas referentes às vias aéreas superiores. Apresentava lesão granulomatosa em orofaringe e laringe, e o resultado da biópsia revelou bacilos álcool-ácido resistentes. Exames clínico e radiológico do aparelho respiratório sem alterações. Realizado tratamento anti-tuberculose por nove meses com resolução completa do quadro. CONCLUSÃO: Autores realçam a importância epidemiológica da tuberculose e a necessidade de um alto grau de suspeição de lesões das vias aéreas superiores para o diagnóstico precoce da doença.<br>Tuberculosis of the Larynx and pharynx only is rare. However, in the last few years, the number of tuberculosis cases in general have had a dramatic increase, thus increasing the possibility of isolated laryngo-pharyngeal lesions. AIM: To report a case of isolated laryngo-pharyngeal tuberculosis in a pregnant, immunocompetent host. CASE REPORT: A 30- year-old pregnant female had complained of odynophagia for the last ten months. There were no other respiratory or systemic symptoms. An oro-pharyngeal granulomatous lesion was found, and the biopsy revealed acid-fast bacilli. There were no clinical or radiologic pulmonary findings. She was submitted successfully to an tuberculosis treatment protocol for nine months. CONCLUSIONS: The authors point out the epidemiological importance of tuberculosis and the need for a higher degree of suspicion when dealing with uncommon upper airway lesions to make an early diagnosis