An empirical investigation of the influence of collaboration in Finance on article impact

We investigate the impact of collaborative research in academic Finance literature to find out whether and to what extent collaboration leads to higher impact articles (6,667 articles across 2001-2007 extracted from the Web of Science). Using the top 5 % as ranked by the 4-year citation counts following publication, we also follow related secondary research questions such as the relationships between article impact and author impact; collaboration and average author impact of an article; and, the nature of geographic collaboration. Key findings indicate: collaboration does lead to articles of higher impact but there is no significant marginal value for collaboration beyond three authors; high impact articles are not monopolized by high impact authors; collaboration and the average author impact of high-impact articles are positively associated, where collaborative articles have a higher mean author impact in comparison to single-author articles; and collaboration among the authors of high impact articles is mostly cross-institutional

Phosphodiesterase-III Inhibitor Prevents Hemorrhagic Transformation Induced by Focal Cerebral Ischemia in Mice Treated with tPA

The purpose of the present study was to investigate whether cilostazol, a phosphodiesterase-III inhibitor and antiplatelet drug, would prevent tPA-associated hemorrhagic transformation. Mice subjected to 6-h middle cerebral artery occlusion were treated with delayed tPA alone at 6 h, with combined tPA plus cilostazol at 6 h, or with vehicle at 6 h. We used multiple imaging (electron microscopy, spectroscopy), histological and neurobehavioral measures to assess the effects of the treatment at 18 h and 7 days after the reperfusion. To further investigate the mechanism of cilostazol to beneficial effect, we also performed an in vitro study with tPA and a phosphodiesterase-III inhibitor in human brain microvascular endothelial cells, pericytes, and astrocytes. Combination therapy with tPA plus cilostazol prevented development of hemorrhagic transformation, reduced brain edema, prevented endothelial injury via reduction MMP-9 activity, and prevented the blood-brain barrier opening by inhibiting decreased claudin-5 expression. These changes significantly reduced the morbidity and mortality at 18 h and 7 days after the reperfusion. Also, the administration of both drugs prevented injury to brain human endothelial cells and human brain pericytes. The present study indicates that a phosphodiesterase-III inhibitor prevents the hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tPA

The efficacy of a self-paced VO2max test during motorized treadmill exercise

PURPOSE To assess the utility of a self-paced maximal oxygen uptake (VO2max) test (SPV) in eliciting an accurate measure of VO2max in comparison with a traditional graded exercise test (GXT) during motorized treadmill exercise. DESIGN This was a cross-sectional experimental study whereby recreationally trained men (n = 13, 25.5 ± 4.6 y) completed 2 maximal exercise tests (SPV, GXT) separated by a 72-h recovery period. METHODS The GXT was continuous and incremental, with prescribed 1-km/h increases every 2 min until the attainment of VO2max. The SPV consisted of 5 × 2-min stages of incremental exercise, which were self-selected and adjusted according to 5 prescribed RPE levels (RPE 11, 13, 15, 17, and 20). RESULTS Although no significant differences in VO2max were observed between the SPV and GXT (63.9 ± 3.3 cf 60.9 ± 4.6 mL · kg-1 · min-1, respectively, P > .05), the apparent 4.7% mean difference may be practically important. The 95% limits-of-agreement analysis was 3.03 ± 11.49 mL · kg-1 · min-1. Therefore, in the worst-case scenario, the GXT may underestimate measured VO2max as ascertained by the SPV by up to 19%. Conversely, the SPV could underestimate the GXT by 14%. CONCLUSIONS The current study has shown that the SPV is an accurate measure of VO2max during exercise on a motorized treadmill and may provide a slightly higher VO2max value than that obtained from a traditional GXT. The higher VO2max during the SPV may be important when prescribing training or monitoring athlete progression