5 research outputs found
Use of a novel plasmid to monitor the fate of a genetically engineered Pseudomonas putida strain
Effect of Bacillus subtilis on the rumen microbial community and its components exhibiting high correlation coefficients with the host nutrition, growth, and development
Efficacy of Glimepiride in Patients with Poorly Controlled Insulin-treated Type 2 Diabetes Mellitus
The quest to slow ageing through drug discovery
Although death is inevitable, individuals have long sought to alter the course of the ageing process. Indeed, ageing has proved to be modifiable; by intervening in biological systems, such as nutrient sensing, cellular senescence, the systemic environment and the gut microbiome, phenotypes of ageing can be slowed sufficiently to mitigate age-related functional decline. These interventions can also delay the onset of many disabling, chronic diseases, including cancer, cardiovascular disease and neurodegeneration, in animal models. Here, we examine the most promising interventions to slow ageing and group them into two tiers based on the robustness of the preclinical, and some clinical, results, in which the top tier includes rapamycin, senolytics, metformin, acarbose, spermidine, NAD+ enhancers and lithium. We then focus on the potential of the interventions and the feasibility of conducting clinical trials with these agents, with the overall aim of maintaining health for longer before the end of life