1,773 research outputs found
Entomological aspects of the first five years of the Onchocerciasis Control Programme in the Volta river basin
The effects of helicopter applied adulticides for riverine tsetse control on Simulium populations in a West African savanna habitat : 1. Introduction, methods and the effect on biting adults and aquatic stages of Simulium damnosum s.l.
Quenched QCD at finite density: and
We report on our ongoing effort to understand quenched lattice QCD at finite
baryon number density. The quenched theory is sensitive to the baryon mass both
at strong coupling and in the scaling region. However, we find that the
quenched model is pathological for at , in
agreement with past Lanczos analyses of the Dirac operator.Comment: Contribution to Lat94, 3 pages, tar-compressed uuencoded ps fil
Unitarity of Quantum Theory and Closed Time-Like Curves
Interacting quantum fields on spacetimes containing regions of closed
timelike curves (CTCs) are subject to a non-unitary evolution . Recently, a
prescription has been proposed, which restores unitarity of the evolution by
modifying the inner product on the final Hilbert space. We give a rigorous
description of this proposal and note an operational problem which arises when
one considers the composition of two or more non-unitary evolutions. We propose
an alternative method by which unitarity of the evolution may be regained, by
extending to a unitary evolution on a larger (possibly indefinite) inner
product space. The proposal removes the ambiguity noted by Jacobson in
assigning expectation values to observables localised in regions spacelike
separated from the CTC region. We comment on the physical significance of the
possible indefiniteness of the inner product introduced in our proposal.Comment: 13 pages, LaTeX. Final revised paper to be published in Phys Rev D.
Some changes are made to expand our discussion of Anderson's Proposal for
restoring unitarit
Arrow of time in a recollapsing quantum universe
We show that the Wheeler-DeWitt equation with a consistent boundary condition
is only compatible with an arrow of time that formally reverses in a
recollapsing universe. Consistency of these opposite arrows is facilitated by
quantum effects in the region of the classical turning point. Since
gravitational time dilation diverges at horizons, collapsing matter must then
start re-expanding ``anticausally" (controlled by the reversed arrow) before
horizons or singularities can form. We also discuss the meaning of the
time-asymmetric expression used in the definition of ``consistent histories".
We finally emphasize that there is no mass inflation nor any information loss
paradox in this scenario.Comment: Many conceptual clarifications include
Classical Vs Quantum Probability in Sequential Measurements
We demonstrate in this paper that the probabilities for sequential
measurements have features very different from those of single-time
measurements. First, they cannot be modelled by a classical stochastic process.
Second, they are contextual, namely they depend strongly on the specific
measurement scheme through which they are determined. We construct
Positive-Operator-Valued measures (POVM) that provide such probabilities. For
observables with continuous spectrum, the constructed POVMs depend strongly on
the resolution of the measurement device, a conclusion that persists even if we
consider a quantum mechanical measurement device or the presence of an
environment. We then examine the same issues in alternative interpretations of
quantum theory. We first show that multi-time probabilities cannot be naturally
defined in terms of a frequency operator. We next prove that local hidden
variable theories cannot reproduce the predictions of quantum theory for
sequential measurements, even when the degrees of freedom of the measuring
apparatus are taken into account. Bohmian mechanics, however, does not fall in
this category. We finally examine an alternative proposal that sequential
measurements can be modelled by a process that does not satisfy the Kolmogorov
axioms of probability. This removes contextuality without introducing
non-locality, but implies that the empirical probabilities cannot be always
defined (the event frequencies do not converge). We argue that the predictions
of this hypothesis are not ruled out by existing experimental results
(examining in particular the "which way" experiments); they are, however,
distinguishable in principle.Comment: 56 pages, latex; revised and restructured. Version to appear in
Found. Phy
Thermal and pCO2 stress elicit divergent transcriptomic responses in a resilient coral
The oceans are becoming warmer and more acidic as a result of rising atmospheric pCO2. Transcriptome plasticity may facilitate marine organisms' acclimation to thermal and acidification stress by tailoring gene expression to mitigate the impacts of these stressors. Here, we produce the first transcriptome of the abundant, ubiquitous, and resilient Caribbean reef-building coral Siderastrea siderea, and investigate this corals' transcriptomic response to 95 days of thermal (T = 25, 28, 32°C) and CO2-induced acidification (324, 477, 604, 2553 Όatm) stress. The S. siderea transcriptome was assembled using RNAseq and then Weighted Gene Correlation Network Analysis was employed to obtain systems-level insights into the coral's stress response. Exposure of the coral to both elevated temperature and acidification elicited strong but divergent transcriptomic responses. Gene Ontology analysis suggests that long-term thermal stress disrupts homeostasis by increasing transcription of protein-coding genes associated with protein catabolism and suppressing transcription of genes involved in responding to environmental stimuli. Both next century (604 Όatm) and extreme-high (2553 Όatm) pCO2 stress increased transcription of genes associated with respiration, highlighting the potentially greater energetic requirements of maintaining calcification under high-pCO2 conditions. Under extreme-high-pCO2, increased transcription of H+-transporter genes was observed, consistent with the proposed role of proton transport in facilitating coral calcification under elevated pCO2. These results suggest that 95 days of exposure to 32°C seawater elicits a more adverse transcriptomic response (i.e., broad scale reductions in gene expression) than exposure to extreme-high acidification (2553 Όatm; i.e., increased expression of genes associated with ion transport) within S. siderea-with the response to extreme warming suggesting cellular shutdown and the response to extreme acidification indicating capacity for acclimation. These results are consistent with the observation that rates of net calcification for the investigated corals were more negatively affected by the prescribed thermal stress than by the prescribed acidification stress. This study demonstrates how transcriptome plasticity may promote coral acclimation to these global change stressors, but that there are limits to the efficacy of this plasticity
100 years on: The impact of the discovery of insulin on clinical outcomes
Throughout history, up to the early part of the 20th century, diabetes has been a devastating disorder, particularly when diagnosed in childhood when it was usually fatal. Consequently, the successful pancreatic extraction of insulin in 1921 was a miraculous, life-changing advance. In this review, the truly transformative effect that insulin has had on the lives of people with type 1 diabetes and on those with type 2 diabetes who are also dependent on insulin is described, from the time of its first successful use to the present day. We have highlighted in turn how each of the many facets of improvements over the last century, from advancements in the properties of insulin and its formulations to the evolution of different methods of delivery, have led to continued improvement in clinical outcomes, through the use of illustrative stories from history and from our own clinical experiences. This review concludes with a brief look at the current challenges and where the next century of technological innovation in insulin therapy may take us
A comparison between different propagative schemes for the simulation of tapered step index slab waveguides
The performance and accuracy of a number of propagative algorithms are compared for the simulation of tapered high contrast step index slab waveguides. The considered methods include paraxial as well as nonparaxial formulations of optical field propagation. In particular attention is paid to the validity of the paraxial approximation. To test the internal consistency of the various methods the property of reciprocity is verified and it is shown that for the paraxial algorithms the reciprocity can only be fulfilled if the paraxial approximation of the power flux expression using the Poynting vector is considered. Finally, modeling results are compared with measured fiber coupling losses for an experimentally realized taper structure
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