617 research outputs found
Mutant Prevention Concentrations of Imipenem and Meropenem against Pseudomonas aeruginosa
The aim of this study was to determine the usefulness of the MPC of carbapenems against clinical isolates of Pseudomonas spp. and Acinetobacter spp. and to assess its possible relationship with mechanisms of resistance. Detection of the mechanisms of resistance was performed using Antibiotic Susceptibility Testing, Double Disk Synergy, disk antagonism, addition of NaCl to the medium, addition of PBA or EDTA to Carbapenem disks, addition of PBA to Cefoxitin disks, and CCCP test for 10 Pseudomonas spp. and Acinetobacter baumannii strains. The MIC and MPC were determined using the broth macrodilution and plate dilution methods, respectively. Four Acinetobacter baumannii strains produced MBL. Two of them produced Oxacillinase and one produced ESBL. Two Pseudomonas spp. isolates produced both KPC and MBL. The resistant Acinetobacter spp. and Pseudomonas spp. strains had higher MPC values than susceptible ones. However, the Mutant Selection Window was found to be dependent on the degree of resistance but not on a particular mechanism of resistance. The usefulness of the MPC was found to be dependent on its value. Based on our data, we recommend determining the MPC for each isolate before using it during treatment. Furthermore, the use of T>MSW instead of T>MIC is suggested
A long survival of a patient with brain metastasis of unknown site of the primary tumor
Eighty percent of brain metastases (BM) are diagnosed in patients with known primary site of cancer. BM of unknown primary represents a difficult diagnosis. In up to 15% of patients with BM, the site of the primary tumor will not be detected despite investigations. The prognosis of this entity is very poor. We report here a case of a long survival of a patient with brain metastasis of unknown primary. The conclusion that can be drawn is that within BM of unknown primary exist patients with a very good prognosis that must be collected and published in order to base recommendations
Influence of long-range correlated quenched disorder on the adsorption of long flexible polymer chains on a wall
The process of adsorption on a planar wall of long-flexible polymer chains in
the medium with quenched long-range correlated disorder is investigated. We
focus on the case of correlations between defects or impurities that decay
according to the power-low for large distances , where . Field theoretical approach in and directly in
dimensions up to one-loop order for the semi-infinite m-vector
model (in the limit ) with a planar boundary is used. The whole set of
surface critical exponents at the adsorption threshold , which separates
the nonadsorbed region from the adsorbed one is obtained. Moreover, we
calculate the crossover critical exponent and the set of exponents
associated with them. We perform calculations in a double and
expansion and also for a fixed dimension , up to one-loop
order for different values of the correlation parameter .
The obtained results indicate that for the systems with long-range correlated
quenched disorder the new set of surface critical exponents arises. All the
surface critical exponents depend on . Hence, the presence of long-range
correlated disorder influences the process of adsorption of long-flexible
polymer chains on a wall in a significant way.Comment: 4 figures, 2 table
Scattering from supramacromolecular structures
We study theoretically the scattering imprint of a number of branched
supramacromolecular architectures, namely, polydisperse stars and dendrimeric,
hyperbranched structures. We show that polydispersity and nature of branching
highly influence the intermediate wavevector region of the scattering structure
factor, thus providing insight into the morphology of different aggregates
formed in polymer solutions.Comment: 20 pages, 8 figures To appear in PR
Charge and Orbital Ordering in Pr_{0.5} Ca_{0.5} MnO_3 Studied by ^{17}O NMR
The charge and orbital ordering in Pr_{0.5} Ca_{0.5} MnO_3 is studied for the
first time by ^{17}O NMR. This local probe is sensitive to spin, charge and
orbital correlations. Two transitions exist in this system: the charge and
orbital ordering at T_{CO} = 225 K and the antiferromagnetic (AF) transition at
T_N = 170 K. Both are clearly seen in the NMR spectra measured in a magnetic
field of 7T. Above T_{CO} there exists only one NMR line with a large isotropic
shift, whose temperature dependence is in accordance with the presence of
ferromagnetic (FM) correlations. This line splits into two parts below T_{CO},
which are attributed to different types of oxygen in the charge/orbital ordered
state. The interplay of FM and AF spin correlations of Mn ions in the charge
ordered state of Pr_{0.5} Ca_{0.5} MnO_3 is considered in terms of the hole
hopping motion that is slowed down with decreasing temperature. The developing
fine structure of the spectra evidences, that there still exist
charge-disordered regions at T_{CO} > T > T_N and that the static (t >
10^{-6}s) orbital order is established only on approaching T_N. The CE-type
magnetic correlations develop gradually below T_{CO}, so that at first the AF
correlations between checkerboard ab-layers appear, and only at lower
temperature - CE correlations within the ab-planes
Ferromagnetic Polarons in La0.5Ca0.5MnO3 and La0.33Ca0.67MnO3
Unrestricted Hartree-Fock calculations on La0.5Ca0.5MnO3 and La0.33Ca0.67MnO3
in the full magnetic unit cell show that the magnetic ground states of these
compounds consist of 'ferromagnetic molecules' or polarons ordered in
herring-bone patterns. Each polaron consists of either three or five Mn ions
separated by O- ions with a magnetic moment opposed to those of the Mn ions.
Ferromagnetic coupling within the polarons is strong while coupling between
them is relatively weak. Magnetic moments on the Mn ions range between 3.8 and
3.9 Bohr magnetons in La0.5Ca0.5MnO3 and moments on the O- ions are -0.7 Bohr
magnetons. Each polaron has a net magnetic moment of 7.0 Bohr magnetons, in
good agreement with recently reported magnetisation measurements from electron
microscopy. The polaronic nature of the electronic structure reported here is
obviously related to the Zener polaron model recently proposed for
Pr0.6Ca0.4MnO3 on the basis of neutron scattering data.Comment: 4 pages 5 figure
Bilayer manganites: polarons in the midst of a metallic breakdown
The exact nature of the low temperature electronic phase of the manganite
materials family, and hence the origin of their colossal magnetoresistant (CMR)
effect, is still under heavy debate. By combining new photoemission and
tunneling data, we show that in La{2-2x}Sr{1+2x}Mn2O7 the polaronic degrees of
freedom win out across the CMR region of the phase diagram. This means that the
generic ground state is that of a system in which strong electron-lattice
interactions result in vanishing coherent quasi-particle spectral weight at the
Fermi level for all locations in k-space. The incoherence of the charge
carriers offers a unifying explanation for the anomalous charge-carrier
dynamics seen in transport, optics and electron spectroscopic data. The
stacking number N is the key factor for true metallic behavior, as an
intergrowth-driven breakdown of the polaronic domination to give a metal
possessing a traditional Fermi surface is seen in the bilayer system.Comment: 7 pages, 2 figures, includes supplementary informatio
Charge Ordering and Ferroelectricity in Half-doped Manganites
By means of density-functional simulations for half-doped manganites, such as
pseudocubic Pr0.5Ca0.5MnO3 and bilayer PrCa2Mn2O7, we discuss the occurrence of
ferroelectricity and we explore its crucial relation to the crystal structure
and to peculiar charge/spin/orbital ordering effects. In pseudocubic
Pr0.5Ca0.5MnO3, ferroelectricity is induced in the Zener polaron type
structure, where Mn ions are dimerized. In marked contrast, in bilayer
PrCa2Mn2O7, it is the displacements of apical oxygens bonded to either Mn3+ or
Mn4+ ions that play a key role in the rising of ferroelectricity. Importantly,
local dipoles due to apical oxygens are also intimately linked to charge and
orbital ordering patterns in MnO2 planes, which in turn contribute to
polarization. Finally, an important outcome of our work consists in proposing
Born effective charges as a valid mean to quantify charge disproportionation
effects, in terms of anisotropy and size of electronic clouds around Mn ions.Comment: 5 pages, 2 figures, submitted for publicatio
Random Walks with Long-Range Self-Repulsion on Proper Time
We introduce a model of self-repelling random walks where the short-range
interaction between two elements of the chain decreases as a power of the
difference in proper time. Analytic results on the exponent are obtained.
They are in good agreement with Monte Carlo simulations in two dimensions. A
numerical study of the scaling functions and of the efficiency of the algorithm
is also presented.Comment: 25 pages latex, 4 postscript figures, uses epsf.sty (all included)
IFUP-Th 13/92 and SNS 14/9
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